Skin pathergy reaction (SPR) is a hyperreactivity response to needle induced trauma which is characterized by a papule or pustule formation, 24–48 h after sterile-needle prick. It is affected by a wide array of factors, including the physical properties of the needles being used, number of pricks and disease related factors such as male gender, active disease. There is a great variation in reactivity among different populations with very low positivity rate in regions of low prevalence like Northern Europe, and higher prevalance mainly in communities living along the historical Silk Road, like Turkey, China and Middle Eastern countries. SPR is not constant during the disease course, has lost its sensitivity over decades and can be positive in various disorders including Sweet's syndrome, pyoderma gangrenosum, Crohn's diesease, A20 haploinsufficiency, deficiency of IL-1-receptor antagonist and few others. Nevertheless, it is a criteria included into many currently used diagnostic or classification criteria for Behçet's disease. Although, not being fully uncovered yet, available data points to the activation of both innate and adaptive immune system with an inflammatory response mediated by polymorphonuclears and T-cells. In addition to its utility in diagnosis of Behçet's Disease, SPR may serve as a model for investigating the inflammatory pathways involved in the etiopathogenesis of this complex disease.

Negative body image appraisals may effect the sexual functions, avoidance, and level of finding oneself sexually attractive. The aim of the study is to assess the levels of sexual dysfunction and sexual satisfaction in patients with psoriasis and the effect of the body image appraisal on sexual functions and satisfaction. In all, 216 individuals were included in the study, and 112 of them had psoriasis; 104 individuals who never experienced any skin problems participated in the study and answered questions that assess depression and anxiety levels, sexual problems and satisfaction, as well as body image appraisal. Psoriasis patients showed significantly higher levels of sexual impairments and less satisfaction with sexual life compared to controls. The psoriasis group had lower body image satisfaction compared to the controls. Depression and anxiety levels in the psoriasis group were higher than in the control group. The cognitive meaning of skin involvement as body image satisfaction was found to be the most significant risk factor that affected sexual functions in psoriasis patients. It also predicted sexual satisfaction in the patient group. However, the objective measure of the severity of the disease as Psoriasis Area and Severity Index (PASI) was not a determinant of sexual dysfunctions and satisfaction.

Objective: The aim of this study was to assess the contributing factors for oral ulcer activity in Behçet’s disease (BD). Methods: Ninety-two patients with BD (F/M: 42/50, mean age: 38.7±10.02 years) participated in this cross-sectional study. Data regarding disease-related factors, smoking patterns, and self-reported dietary/non-dietary triggering factors for oral ulcer activity were collected by a questionnaire. Treatment protocol was categorized as mild and intensive groups associated with organ involvements. Results: A mild treatment protocol was more common in females (52.4% vs 20%) than in males (p=0.002). During the last three months, the number of oral ulcers in female patients was higher in the mild treatment group (6.4±6.5) than in the intensive treatment group (3.3±4.9) (p=0.045). In patients with active oral ulcers (n=63), rate of being a non-smoker was also higher in females (86.7% vs 63.6%) than in males. Daily frequency of tooth brushing was 1.2±0.8 in patients with BD, and was higher in females (1.5±0.9 vs 0.9±0.6) (p=0.001). Stress and fatigue (78.3%) were reported as the most frequent triggering factors for oral ulcer presence in patients with BD. A total of 148 different dietary factors associated with oral ulcer presence were reported in the study. Conclusion: A mild treatment protocol and being a non-smoker were found to be the contributing factors associated with oral ulcer activity in patients with BD. Being motivated for oral hygiene and being non-smokers were positive health behaviors observed in females. Irrespective of gender, stress and fatigue were defined as the most common self-reported triggering factors for oral ulcer presence in BD. In addition, the roles of some dietary factors were also reported. Cite this article as: İris M, Özçıkmak E, Aksoy A, Alibaz-Öner F, İnanç N, Ergun T, et al. The assessment of contributing factors to oral ulcer presence in Behçet’s disease: Dietary and non-dietary factors. Eur J Rheumatol 2018; 5: 240-3.

Alpsoy E, et al. Ann Dermatol. 2020 Jun;32(3):181-188. https://doi.org/10.5021/ad.2020.32.3.181