The Massachusetts Eye and Ear Infirmary (MEEI) database is an international-standard training database for voice pathology detection (VPD) systems. However, there is a class-imbalanced distribution in normal and pathological voice samples and different types of pathological voice samples in the MEEI database. This study aimed to develop a VPD system that uses the fuzzy clustering synthetic minority oversampling technique algorithm (FC-SMOTE) to automatically detect and classify four types of pathological voices in a multi-class imbalanced database. The proposed FC-SMOTE algorithm processes the initial class-imbalanced dataset. A set of machine learning models was evaluated and validated using the resulting class-balanced dataset as an input. The effectiveness of the VPD system with FC-SMOTE was further verified by an external validation set and another pathological voice database (Saarbruecken Voice Database (SVD)). The experimental results show that, in the multi-classification of pathological voice for the class-imbalanced dataset, the method we propose can significantly improve the diagnostic accuracy. Meanwhile, FC-SMOTE outperforms the traditional imbalanced data oversampling algorithms, and it is preferred for imbalanced voice diagnosis in practical applications.

Sulcus vocalis is an indentation parallel to the edge of vocal fold, which may extend into the cover and ligament layer of the vocal fold or deeper. The effects of sulcus vocalis depth on phonation and the vocal cord vibrations are investigated in this study. The three-dimensional laryngeal models were established for healthy vocal folds (0 mm) and different types of sulcus vocalis with the typical depth of 1 mm, 2 mm, and 3 mm. These models with fluid-structure interaction (FSI) are computed numerically by sequential coupling method, which includes an immersed boundary method (IBM) for modelling the glottal airflow, a finite-element method (FEM) for modelling vocal fold tissue. The results show that a deeper sulcus vocalis in the cover layer decreases the vibrating frequency of vocal folds and expands the prephonatory glottal half-width which increases the phonation threshold pressure. The larger sulcus vocalis depth makes vocal folds difficult to vibrate and phonate. The effects of sulcus vocalis depth suggest that the feature such as phonation threshold pressure could assist in the detection of healthy vocal folds and different types of sulcus vocalis.