Over the past 18 years, my research program has centered upon diabetes and the biology of the islet. Four distinct but inter-related research themes have emerged in my research over the years: (1) The biochemical properties of islet-specific transcription factors and the mechanisms by which they regulate islet development and function, (2) the structure and role of islet gene chromatin in the maintenance of islet function, (3) the integration of extracellular signals (e.g. cytokines, lipids, and glucose) with intra-islet proliferative and survival pathways in the setting of diabetes, and (4) the identification of biomarkers of β cell stress and death in diabetes. More recently, my research has focused on the identification and development of biomarkers, and my lab has developed and validated epigenetic DNA-based biomarkers, but also biomarkers of RNA and proteins that report on the health of β-cells.
Alumni Achievement Award
Libertyville High School
Merv Yoder Award for Excellence in Mentoring
Indiana University School of Medicine
US Provisional Patent Application 62/291,018; filed February 4, 2016
Indiana University
Excellence in Faculty Mentoring Award for Basic Science
Indiana University School of Medicine
Top Doctor, Endocrinology and Metabolism
Indianapolis Monthly Magazine
University Educator/Researcher
The University of Chicago
01 Nov 2019 - present
Institute, Department or Faculty Head
The University of Chicago; Director, University of Chicago Translational Research Center
01 Nov 2019 - present
Institute, Department or Faculty Head
Indiana University School of Medicine; Director, Wells Center for Pediatric Research
01 Apr 2017 - 01 Oct 2019
Institute, Department or Faculty Head
Indiana University School of Medicine; Director, IU Center for Diabetes and Metabolic Diseases
01 Feb 2014 - 01 Oct 2019
Institute, Department or Faculty Head
Indiana University School of Medicine; Eli Lilly Professor in Pediatric Diabetes; and Professor of Pediatrics, Medicine, Physiology, and Biochemistry
01 Jan 2010 - 01 Oct 2019
Institute, Department or Faculty Head
Indiana University School of Medicine; Director, Medical Scientist Training Program (MSTP)
01 Jan 2010 - 01 Oct 2019
Institute, Department or Faculty Head
Indiana University School of Medicine, Eli Lilly Chair in Pediatric Diabetes; and Associate Professor of Pediatrics, Medicine, and Cellular and Integrative Physiology; and Director, Pediatric Basic Diabetes Research Program,
01 Dec 2008 - 01 Oct 2019
University Educator/Researcher
University of Virginia, Departments of Medicine and Pharmacology
01 Jan 2005 - 01 Dec 2008
Institute, Department or Faculty Head
University of Virginia Diabetes and Hormone Center of Excellence
01 May 2003 - 01 Dec 2008
University Educator/Researcher
University of Virginia, Department of Medicine
01 Jan 2000 - 01 Jan 2005