Thomas J. J. Müller

Prof. Thomas J. J. Müller

Heinrich-Heine-Universität Düsseldorf
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Research Focus & Metrics

Academic Career Length

33Years (1994-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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19 February 2007 in Chemical Society Reviews
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DDDaniel M. D'Souza
Daniel M. D'Souza
TMThomas J. J. Müller
Thomas J. J. Müller
For a long time multi-component syntheses of heterocycles have undeniably been a domain of classical carbonyl condensation chemistry. However, the advent of transition-metal catalysis not only has fertilized strategies in heterocyclic synthesis by uni- and bimolecular transformations but the past decade has also witnessed a rapid development of transition-metal catalysis in new multi-component reactions (MCR). Expectedly, palladium catalyzed processes have received a dominant position, yet, other transition-metal complexes are catching up implying organometallic elementary steps that reach even further than cross-coupling and carbometallation. Besides domino MCRs that are purely based upon organometallic catalysis the sequential and consecutive combination with condensation, addition and cycloaddition steps opens a vast playground for the invention of new sequences in heterocyclic synthesis. This tutorial review outlines the underlying reaction based principles of transition-metal catalysis in multi-component syntheses of heterocycles, summarizes recent developments of palladium catalyzed MCR, and highlights the more recent contributions to MCR based heterocyclic synthesis by virtue of rhodium, ruthenium, and copper catalysis.

22 February 2016 in Chemical Society Reviews
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LLLucilla Levi
Lucilla Levi
TMThomas J. J. Müller
Thomas J. J. Müller
Multicomponent reactions are a valuable tool for the synthesis of functional π-electron systems. Two different approaches can be taken into account for accessing the target structures. In the more conventional scaffold approach an already existing chromophore is coupled with other components to give a complex functional π-system. Here, electronically monotonous components can also be introduced, which may exert synergistic electronic effects within the novel compound. The more demanding chromophore concept generates a complete π-electron system and a scaffold concurrently. The latter approach is particularly stimulating for methodologists since π-systems might be accessible from simple starting materials. This review encompasses the advances in the preparation of functional π-electron systems via multicomponent processes during the past few years, based both on the scaffold and chromophore concepts. Besides the synthetic strategies the most important properties, i.e. redox potentials, absorption and emission maxima or fluorescence quantum yields, of the synthesized molecules are highlighted.

21 August 2003 in Organic Letters
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AKAlexei S. Karpov
Alexei S. Karpov
TMThomas J. J. Müller
Thomas J. J. Müller

25 October 2005 in Angewandte Chemie International Edition
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AKAlexei S. Karpov
Alexei S. Karpov
EMEugen Merkul
Eugen Merkul
FRFrank Rominger
Frank Rominger
TMThomas J. J. Müller
Thomas J. J. Müller

18 September 2001 in Organic Letters
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Journal Article
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RBRoland U. Braun
Roland U. Braun
KZKirsten Zeitler
Kirsten Zeitler
TMThomas J. J. Müller
Thomas J. J. Müller

4 February 2015 in Advanced Synthesis & Catalysis
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SHSidra Hassan
Sidra Hassan
TMThomas J. J. Müller
Thomas J. J. Müller