Khondaker Miraz Rahman

Dr. Khondaker Miraz Rahman

Institute of Pharmaceutical Science, King's College London, London, UK
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Biography

Khondaker Miraz Rahman is a Professor of Medicinal Chemistry at the School of Cancer & Pharmaceutical Sciences, King’s College, London. After working for 3 years in the industry, he went back to academia and obtained his PhD from the UCL School of Pharmacy in synthetic medicinal chemistry. His research activities are focused on the application of advanced computational chemistry, synthetic medicinal chemistry and chemical biology techniques to the design, synthesis and evaluation of novel drug-like chemical scaffolds as anticancer and anti-infective agents. He has been working on pyrrolobenzodiazepine-based DNA binding agents for the past 16 years and developed PBD-based anticancer and antibacterial agents that have been patented and licensed to university spin-out companies. He is working with UK Health Security Agency to develop chemical tools to study antimicrobial resistance (AMR) and discover new ways to target multiple drug-resistant pathogens. He has used a combination of homology modelling and advanced computational calculations to study bacterial and fungal efflux pumps and has invented new classes of efflux-resistant antibiotics and antifungal agents that are currently being commercialised. He has experience in early- and late-stage drug discovery, and translational research, co-founding oncology biotech companies Transcriptogen Ltd. (2013), Femtogenix Ltd. (2015) and Pheon Therapeutics (2022).

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