Objectives: This review article aims to describe some of the roles of Matrix metalloproteinases (MMPs) in enamel, dentine, dental caries, hybrid layer degradation, pulp and periodontal tissues, throwing light on their current inhibitors. The article addresses the potential of MMPs to serve as biomarkers with diagnostic and therapeutic value. Design: The sections of this review discuss MMPs’ involvement in developmental, remodeling, degradational and turnover aspects of dental and periodontal tissues as well as their signals in the pathogenesis, progress of different lesions and wound healing of these tissues. The literature was searched for original research articles, review articles and theses. The literature search was conducted in PubMed and MEDLINE for articles published in the last 20 years. Results: 119 published papers, two textbooks and two doctoral theses were selected for preparing the current review. Conclusions: MMPs are significant proteases, of evident contribution in dental and periapical tissue development, health and disease processes, with promising potential for use as diagnostic and prognostic disease biomarkers. Continuing understanding of their role in pathogenesis and progress of different dental, periapical and periodontal lesions, as well as in dentine-pulp wound healing could be a keystone to future diagnostic and therapeutic regimens.

Background: smoking is considered the most modifiable risk factor for periodontal disease. Objective: the aim of this narrative review is to emphasize the effect of smoking on periodontal and implant therapy. Methods: The authors reviewed the literature reporting the clinical outcomes of smoking on periodontal surgical and nonsurgical treatment. The impact of smoking on implant therapy and sinus lifting procedures were also reviewed. Results: Periodontal and implant therapy outcomes are adversely affected by smoking. Smokers respond less favorably to periodontal therapy and periodontal flap procedures as compared to nonsmokers. Clinical outcomes for smokers are 50–75% worse than for nonsmokers. Studies reveal that smokers experience a significantly lower reduction in pocket depth compared to nonsmokers as well as less bone growth after treating infra-bony defects with guided tissue regeneration. The relative risk of implant failure is significantly higher in patients who smoke 20 cigarettes or more per day compared to nonsmokers. Additionally, smoking has also been shown to increase postoperative wound dehiscence and infection rates following sinus floor elevation. Longitudinal studies on smoke cessation have shown a reduction in bone loss and probing depths for periodontitis patients after cessation compared to those who smoke. Conclusion: Smoking cessation can reduce probing depths and improve clinical attachment after nonsurgical periodontal therapy. There is insufficient evidence regarding the effect of smoking on peri-implantitis, as well as the loss of implants in the long-term.

Objective. To evaluate the reasons for permanent teeth extractions and related factors among adult patients visiting dental clinics in the Eastern Province of Saudi Arabia. Materials and Methods. This retrospective cross-sectional study included data of patients who underwent teeth extractions. Data were collected from public and private dental clinics in different cities of the Eastern Province of Saudi Arabia (January–March 2020). The demographic information of patients and their reasons for teeth extractions were obtained from participating dentists. Results. The study included data of 696 patients with 55.9% of males and 44.1% of females. The mean number of teeth extractions in the sample was 1.86 ± 1.8, and it increased significantly with advancing age ( ). Saudi (1.97 ± 1.98) versus non-Saudi patients (1.55 ± 1.11) ( ) and patients in public practice (2.03 ± 1.95) versus patients in private practice (1.50 ± 1.38) ( ) showed significantly higher teeth extractions. Dental caries was the most common reason for teeth extractions (49.1%), followed by remaining roots (18.5%), periodontal disease (18.4%), and impactions (7.2%). Most commonly extracted teeth included tooth # 30 (9.8%), followed by tooth #16 (9.6%), tooth # 1 (8.8%), tooth # 19 (8.3%), and tooth # 4 (8.3%). On the other hand, upper incisors were the least commonly extracted teeth. Conclusions. Dental caries, remaining roots, periodontal disease, and impactions were the most common reasons for teeth extractions in our sample of patients. The extractions increased significantly with increasing age. Saudis and patients in public clinics underwent significantly higher teeth extractions. Measures aimed at the prevention and treatment of oral conditions can help reduce teeth extractions and improve the quality of life of patients.

Recently, there have been many global outbreaks of diseases. The latest is the coronavirus disease of 2019 (COVID-19) pandemic. The virus has spread worldwide and is transmitted mainly through droplets or by touching contaminated surfaces. Globally, healthcare systems are challenged due to a lack of workplace safety and professional obligations in addition to the rapid spread of the virus. Dental facilities are at greater risk due to the nature of dental care. The aim of this review study was to provide a situational analysis within dental facilities during the new COVID-19 outbreak. Published papers concerning dental facilities and COVID-19 were retrieved from PubMed, search engines, and organizational websites. All data were reviewed, arranged into themes, and then categorized either as strengths or weaknesses with respect to addressing the COVID-19 pandemic in dental facilities, and accordingly, threats and possible opportunities to the handling of the pandemic were identified. Preparedness of dental facilities during the current pandemic is a weakness that needs to be addressed promptly. Shortage of dental care providers, cyber security, economic losses, and ethical challenges are possible threats due to the current outbreak. Coordination and prompt communication among all healthcare providers during such outbreaks is a strength that needs to be supported. This strengths, weaknesses, opportunities, and threats (SWOT) analysis can be a useful tool for guiding decision-making as it is crucial during the current pandemic to work on weaknesses, avoid threats, and utilize all future opportunities.

This study aimed to investigate the current state of research on tooth extraction socket preservation. The main aim of this study was to consolidate the research published on extraction socket preservation from 1968 to 2020 in Scopus indexed journals. The bibliometric method, a quantitative analysis investigating publishing trends and patterns, was used. Scopus database was used to retrieve the bibliographic records of published scholarly output. The analysis was performed using software and visualization tools like MS Excel, VOSviewer, Cite Space, Biblioshiny (RStudio), and BibExcel. The result showed a gradual increase in research, whereby a substantial increase was observed from 2005 to 2006. Six hundred nineteen articles were published in 173 journals with total citations of 12091. Most published articles were from the USA, Italy, Germany, and China. The authorship pattern showed an interdisciplinary and collaborative approach among researchers. This bibliometric analysis can guide researchers, funding agencies, industry, and institutions.