Administration of drugs via the buccal route has attracted much attention in recent years. However, developing systems with satisfactory adhesion under wet conditions and adequate drug bioavailability still remains a challenge. Here, we propose a mussel-inspired mucoadhesive film. Ex vivo models show that this film can achieve strong adhesion to wet buccal tissues (up to 38.72 ± 10.94 kPa). We also demonstrate that the adhesion mechanism of this film relies on both physical association and covalent bonding between the film and mucus. Additionally, the film with incorporated polydopamine nanoparticles shows superior advantages for transport across the mucosal barrier, with improved drug bioavailability (~3.5-fold greater than observed with oral delivery) and therapeutic efficacy in oral mucositis models (~6.0-fold improvement in wound closure at day 5 compared with that observed with no treatment). We anticipate that this platform might aid the development of tissue adhesives and inspire the design of nanoparticle-based buccal delivery systems.

Local scour is a phenomenon of sediment erosion and transport caused by the dynamic interaction between water flow and seabed sediment, posing a serious threat to the safety of marine engineering structures such as cross-sea bridges and offshore wind turbines. To improve scour prediction and prevention capabilities, this review systematically analyzes the influence mechanisms of factors such as hydrodynamic conditions, sediment characteristics, and structural geometry, and discusses scour protection measures. Based on this, a comprehensive evaluation of the applicability of different prediction methods, including traditional empirical formulas, numerical simulations, probabilistic prediction models, and machine learning (ML) methods, was conducted. The study focuses on analyzing the limitations of existing methods: empirical formulas lack adaptability under complex field conditions, numerical simulation still faces challenges in validating real marine environments, and data-driven models suffer from “black box” issues and insufficient generalization capabilities. Based on the current research progress, this review presents prospects for future development, emphasizing the need to deepen the study of scouring mechanisms in complex real marine environments, develop efficient numerical models for engineering applications, and explore intelligent prediction methods that integrate data-driven approaches with physical mechanisms. This aims to provide more reliable theoretical support for the safe design, risk prevention, and scouring mitigation measures in marine engineering.

In this study, the sediment transport two-phase flow model named SedFOAM is expanded to include soil cohesion, creating a new model named SedCohFOAM within OpenFOAM. The local scouring flume experiment involving a pile on silty seabed and sandy seabed is conducted in a curved flume. Due to the influence of cohesion, the scouring depth at different locations on sandy seabed is 15%–18% greater than that on silty seabed. Observations from this experiment informed the analysis of force balance, wherein the agglomerated silt particles are modeled as large singular entities and the cohesive force is treated as a downward influence that keeps the aggregated particles stationary. Meanwhile, the experimental outcomes are utilized to validate the accuracy of the SedCohFOAM model. The numerical findings demonstrated that SedCohFOAM can simulate the flow field distribution around the pile, variations in seabed shear stress, and alterations in seabed surface morphology. Compared with the SedFOAM model, the SedCohFOAM model has a significantly reduced simulation error in simulating scour on silty seabed. When comparing the cross-sectional profiles of the scour holes derived from the flume experiments with those simulated by SedCohFOAM, it was observed that the ultimate-equilibrium scour depth predicted by the model is consistently lower, but the scour radius in the numerical simulations is larger. The deviation from the experimental results is nearly within 8%, while when the flow velocity is high, the simulation error of the simulated scouring depth behind the pile and the scouring radius in front of pile is amplified.

Skirt–pile foundations have gained widespread attention in the field of offshore engineering due to their ease of installation and high bearing capacity. In this study, the ultimate bearing capacity, pile bending moment distribution and development, cumulative deformation characteristics, and cyclic stiffness development of skirt–pile foundations were investigated using physical model tests. The experimental results indicate that the ultimate bearing capacity and deformation resistance of the foundation can effectively be improved by increasing the skirt diameter. The cumulative deformation of the skirt–piles exhibited rapid development during the initial stages of cyclic loading, eventually stabilizing. Under long-term cyclic loading, the existence of the skirt can share the bending moment, which then affects the internal force distribution of the pile foundation along the axis. The pile foundation’s cyclic stiffness reduces as the loading cycles increase and increases as the skirt diameter and length grow. Meanwhile, the horizontal cyclic stiffness decreases as the number of cycles increases, stabilizing after 3000 cycles. This study can not only deepen the understanding of the deformation laws of skirt–pile foundations in clay soil but also offers some references for the design of offshore pile foundations.

In order to study the failure mechanism of a finned pile foundation under horizontal cyclic loads, a physical model test of the pile–soil interaction of finned pile is designed in this paper. Based on the model tests, the pile top displacement, the cyclic stiffness of the pile foundation, and the response of pore water pressure within the soil around the pile were fully studied for the finned pile foundation under horizontal cyclic loads. It is found that the cyclic stiffness attenuation of the finned pile foundation is more severe than that of a regular single pile foundation, but the final stiffness at equilibrium is still greater than that of a regular single pile foundation. The accumulation of horizontal displacement at the pile top and pore water pressure within the soil around the pile mainly occurs in the first 1000 loading cycles, and an increase in fin plate size will reduce the magnitude of pore water pressure and pile top displacement. This study can not only deepen the understanding of the failure mechanism of finned pile foundation under horizontal cyclic loads, but also provide guidance for the design of the finned pile foundation.