In this invited feature article, the invention of pressurized gyration in 2013 and its subsequent development into sister processes such as pressurized melt gyration, infusion gyration, and pressure‐coupled infusion gyration is elucidated. The fundamentals of these processes are discussed, elucidating how these novel methods can be used to facilitate mass production of polymeric fibers and other morphologies. The effects of the main system parameters: rotational speed and gas pressure, are discussed along with the influence of solution parameters such as viscosity and polymer chain entanglement. The effect of flow of material into the gyrator in infused gyration is also illustrated. Examples of many polymers that have been subjected to these processes are discussed and the applications of resulting products are illustrated under several different research themes such as, tissue engineering, drug delivery, diagnostics, hydrogels, filtration, and wound healing.

As a facile, efficient, and low‐cost fiber manufacturing strategy, pressurized gyration/rotation (PG) is attracting tremendous attention. This review provides a comprehensive introduction to the working setups, fundamental principles, processing parameters, and material feed properties of this technology. The characterizations of products prepared by this technology and their wide application fields are summarized. The development potentials and broader application prospects of PG are discussed. PG holds significant promise for the scale‐up of ultrafine fiber manufacturing.

Centrifugal spinning is a technology used to generate small diameter fibers and has been extensively studied for its vast applications in biomedical engineering. Centrifugal spinning is known for its rapid production rate and has inspired the creation of other technologies which leverage the high‐speed rotation, namely Pressurized Gyration. Pressurized gyration incorporates a unique applied gas pressure which serves to provide additional control over the fiber production process. The resulting fibers are uniquely suitable for a range of healthcare‐related applications that are thoroughly discussed in this work, which involve scaffolds for tissue engineering, solid dispersions for drug delivery, antimicrobial meshes for filtration and bandage‐like fibrous coverings for wound healing. In this review, the notable recent developments in centrifugal spinning and pressurized gyration are presented and how these technologies are being used to further the range of uses of biomaterials engineering, for example the development of core‐sheath fabrication techniques for multi‐layered fibers and the combination with electrospinning to produce advanced fiber mats. The enormous potential of these technologies and their future advancements highlights how important they are in the biomedical discipline.This article is categorized under: Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Biology‐Inspired Nanomaterials > Lipid‐Based Structures

The name casein is given to a family of phosphoproteins which is commonly found in milk. Until recently, this was a constituent of milk that was commonly discarded; however today, it is widely used in health supplements all over the world. In this work, a high loading (50 wt%) of casein is mixed with a solution of polycaprolactone (PCL) to produce bandage-like fibres with an average fibre diameter of 1.4 ± 0.5 µm, which would be used to cover wounds in a series of tests with diabetic rats. Mouse fibroblast cell viability tests show that the casein-loaded fibres had little cytotoxicity with over 90% observed viability. A 14-day in vivo trial involving three groups of rats, used as control (no treatment), pure PCL fibres and casein-loaded fibres, showed that the casein within the fibres contributed to a significantly more extensive healing process. Histological analysis showed increased development of granulation tissue and follicle regrowth for the casein-loaded fibres. Further analysis showed that casein-loaded fibres have significantly lower levels of TNF-α, TGF-β IL-1β, NF-κB and IL-6, contributing to superior healing. The results presented here show an economical and simple approach to advanced wound healing.

One of the key modern advancements of the biomaterial's world has been the recent progress with fibre manufacturing techniques which have allowed for novel approaches to biosensor fabrication. Electrospinning is capable of producing ultrafine and highly tailored fibres that can be made from a wide variety of natural and synthetic materials to be exploited for use as medical sensors. In recent years, electrospinning has been more widely researched and great strides have been made in its ability to produce fibres with more desirable properties. In this mini‐review, the process of electrospinning is overviewed with an emphasis on its properties in producing biosensor components. It is seen how the advancements of nanotechnology allows for easier incorporation of bioreceptors to a larger range of membranes that are capable of higher sensitivity and broader applications. Furthermore, newer manufacturing techniques that are also capable of producing ultra‐thin fibres are elaborated and the future of biosensor production in taking advantage of micro‐ and nano‐scaled components are discussed.