Background: The Oxford–AstraZeneca vaccine (Covishield) was the first to be introduced in Bangladesh to fight the ongoing global COVID-19 pandemic. As this vaccine had shown some side-effects in its clinical trial, we aimed to conduct a study assessing short-term adverse events following immunization (AEFIs) in Bangladesh. Method: A cross-sectional study was conducted on social and electronic media platforms by delivering an online questionnaire among people who had taken at least one dose of the COVID-19 vaccine. The collected data were then analysed to evaluate various parameters related to the AEFIs of the respondents. Results: A total of 626 responses were collected. Of these, 623 were selected based on complete answers and used for the analysis. Most of the respondents were between 30–60 years of age, and 40.4% were female. We found that a total of 8.5% of the total respondents had been infected with the SARS-CoV-2 virus. Our survey revealed that out of 623 volunteers, 317 reported various side-effects after taking the vaccine, which is about 50.88% of the total participants. The majority of participants (37.07%, 231/623) reported swelling and pain at the injection site and fever (25.84%, 162/623); these were some of the common localized and generalized symptoms after the COVID-19 vaccine administration. Conclusion: The side-effects reported after receiving the Oxford–AstraZeneca vaccine (Covishield) are similar to those reported in clinical trials, demonstrating that the vaccines have a safe therapeutic window. Moreover, further research is needed to determine the efficacy of existing vaccines in preventing SARS-CoV-2 infections or after-infection hospitalization.

This research focuses on the associations between cognitive emotion regulation processes, conflict resolution strategies and life satisfaction of persons having different types of love and relationship experiences. Cognitive emotion regulation indicates cognitive reactions, related to the emotional involvement, of our brain to an event that attempts to influence the elicited emotions or that event itself. The study is a cross-sectional one with 310 Bangladeshi respondents in the age range 20-34. Several groups and sub-groups were formulated. For the overall sample, satisfaction with life had a statistically significant positive correlation with adaptive cognitive emotion regulation strategies and conflict resolution styles, while it had a statistically significant negative correlation with less-adaptive cognitive emotion regulation strategies (p < 0.01). ANOVA and t-test analysis showed some crucial findings by comparing the primary groups and sub-groups of the study, regarding differences in life satisfaction and the differences in the uses of specific cognitive emotion regulation strategies for various love experiences. Standard regression analysis of data also revealed that the model explained a large portion of variance (50.40%) in life satisfaction (p < .001).

Introduction: Hypertension refers to the condition where the pressure of blood towards the artery walls is constantly too excessive. Estimated 17.9 million lives each year is taken by this. Its key etiological factors consist of genetic predisposition, unhealthy lifestyle choices, including immoderate salt intake, obesity, lack of physical activity, and chronic situations like kidney disease or hormonal imbalances. Focusing on herbal medications for this will be safer, and affordable alternatives of unwanted risk and negative effects of synthetic medications. Methods and Materials: Six groups of mice were taken. In group 2-5 high fat diet and 3% NaCl was given to induce disease. Group 3,4 and 5 was treated by the ethanolic extract of Nigella sativa, Rouwolfia Serpentina and mixture of Nigella sativa and Rouwolfia Serpentina respectively. Results and Discussion: It has been observed that in all group hypertension condition was restored significantly (p<0.05). In the treatment groups Rouwolfia Serpentina has displayed best efficiency. The mixture of Rouwolfia Serpentina and Nigella sativa showed 2^nd most efficiency. On the other hand, Nigella sativa showed comparatively less but statistically significant (p<0.05) efficacy than others. Nigella sativa significantly (p<0.05) restored disturbed lipid profile (Low density lipoprotein, High density lipoprotein and Triglyceride). Conclusion: As The mixture of the two plant extracts gives both anti-hypertensive and anti- hyperlipidemic activity, it has high potential to be used in hypertension management specially when it is exacerbated by hyperlipidemia and this demands for further study.

Although inflammation is the body's defensive action against cell or tissue damage in order to prevent and treat diseases like infections, chronic or excessive inflammation can be dangerous and can develop several health issues. Nowadays, conventional drugs for inflammation are growing

Introduction: Hypertension (high blood pressure) is an increasingly important global medical and public health problem that is linked to a higher risk of developing cardiovascular disease. Researchers in both developed and developing nations have identified it as one of the most widespread diseases currently present. The investigators are focusing on plants for better, safer, more affordable, and more effective alternatives due to unwanted risks and negative effects of synthetic pharmaceuticals. Allium sativum possesses anticarcinogenic, antioxidant, antidiabetic, renoprotective, anti-atherosclerotic, antibacterial, antifungal, and antihypertensive properties while Rauwolfia serpentina is known to possess pharmacological actions such as hypnotic effect, sedative effect, antihypertensive activity, and anti hypercholesteremic activity. Methods: Sixty rats were divided into six groups, each containing ten rats. With the exception of the negative control group, rats from all groups were given 1% NaCI solution as water and high fat diet as food to induce hypertension. After that, among the six groups one group was treated with Allium sativum, one group with Rauwolfia serpentina and one with the mixture of Rauwolfia serpentina and Allium sativum. Results and Discussion: In case of lipid profile and blood pressure (systolic blood pressure, diastolic blood pressure, and mean blood pressure) both Rauwolfia serpentina and Allium sativum significantly (p<0.05) reversed disturbed pathological state, when compared with disease control group. However, Rauwolfia serpentina demonstrated the highest degree of activity for antihypertensive activity (Mean Blood Pressure 89.79±5.84 mmHg) and Allium sativum is more potent for controlling abnormal lipid profile (Total Cholesterol 125.39±5.59). Conclusion: Therefore, this study provides scientific evidence that Rauwolfia serpentina and Allium sativum have considerable anti-hypertensive and anti-lipidemic activities. More research needs to be done on these plants to isolate particular therapeutic constituents, so that it can be applied more precisely and accurately to mitigate the respective disease.

Because of the short comings of conventional anti-inflammatory drugs, the researchers have driven their attention towards natural products. Medicinal plants have got acknowledged for greatly impacting on the health of individuals and communities. Spondias mombin is a great species, traditionally used for several medicative objectives from ancient times. It has also been popular for it’s analgesic and anti-inflammatory effect. In this study, we an effort was made to evaluate the analgesic and anti-inflammatory effect of Spondias mombin against the conventional drugs. the plant extract from different region was induced through intraperitoneal route and the efficiency was compared with paracetamol and ibuprofen. It was seen that both the conventional drug and extract of Spondias mombin significantly reduce the inflammation. The plant extract has also shown effects irrespective of geographical interest. Hence it might be assumed that Spondias mombin could be a suitable alternative therapy in reducing pain and inflammation and to surpass the side effects of ordinary conventional medicines.