The aim of this study was to analyse the effect of pomegranate juice (POM) supplementation on the levels of selected pro-inflammatory cytokines, hepcidin and markers of iron metabolism in well-trained rowers. The double-blind placebo-controlled study included 19 members of the Polish Rowing Team. The athletes were randomised into the supplemented group (n = 10), receiving 50 ml of standardised POM daily for two months, or the placebo group (n = 9). The subjects performed a 2000 m test on the rowing ergometer at the start of the project (baseline) and end of follow-up period. Blood samples from the antecubital vein were obtained three times during each trial: prior to the exercise, one minute after the test, and following a 24 h recovery. The study documented the beneficial effect of supplementation with pomegranate fruit juice on TAC (P < 0.002). During the resting period, TAC level in the supplemented group was significantly higher than in the placebo group (x ± SD, 2.49 ± 0.39 vs. 1.88 ± 0.45, P < 0.05). The ergometric test conducted at baseline demonstrated a significant post-exercise increase in the concentrations of soluble transferrin receptors (P < 0.04), iron (P < 0.002) and IL-6 (P < 0.02), and to a significant post-exercise decrease in TAC. A significant increase in IL-6 concentration was also observed 24 h post-exercise. The exercise test conducted at the end of the follow-up period resulted in a significant decrease in TBIC and a significant increase in UIBC (P < 0.001), observed in both groups, both immediately post-exercise and after the resting period. Supplementation with POM contributed to a significant strengthening of plasma antioxidant potential in the group of well-trained rowers, but had no effect on iron metabolism markers.

This paper aimed to verify how a supplementation of rower’s diet with Astragalus Membranaceus Root (AMR) modulated their immune system response to maximal physical exertion. The double-blind study included 18 members of the Polish Rowing Team assigned to the supplemented group (n = 10), and the placebo group (n = 8). The participants performed a 2000 m test on a rowing ergometer at the beginning and at the end of the six-week of intensive training camp during which the supplemented group received 500 mg of AMR. Blood samples were obtained prior to, 1 min after completing, and 24 h after the exertion test. The levels of interleukin 2 (IL2), interleukin 4 (IL4), interleukin 10 (IL10), interferon ɤ (IFN-ɣ), and lactic acid were determined. Subpopulations of T regulatory lymphocytes [CD4+/CD25+/CD127−] (Treg), cytotoxic lymphocytes [CD8+/TCRαβ+] (CTL), natural killer cells [CD3−/CD16+/CD56+] (NK), and TCRδγ-positive cells (Tδγ) were determined with flow cytometry. After the camp, the initial NK and Treg levels sustained at the baseline, while Tδγ counts increased relative to the levels in the placebo group. In the supplemented subgroup, a decrease in IL2 level in reaction to maximal exertion clearly deepened while the change in IL-2/IL-10 level induced by the recovery after this exertion clearly increased, relative to the changes in the placebo group. AMR restored the immunological balance in strenuously trained athlets through a stabilization of NK and Treg cells with a positive trend in Tδγ towards Th1 response during restitution by cytokine IL2 modulation.

Purpose: Etiology of hallux valgus (HV) remains unclear and effective treatments and prophylaxis for this condition are lacking and conclusions of researches concerning HV are inconsistent. Recognition of the function-structure interrelation in foot at the early stage of valgus alignment of first metatarsophalangeus joint (1stMTPJ) would help explain the etiology of HV. Methods: The frequency of weight-shifting patterns during walking and the body mass index (BMI) were assessed relative to goniometric measurements of the 1stMTPJ angle in adolescents. Weight-shifting patterns were identified with a plantar pressure analysis, performed with the GaitlineMaxline Distance method. Results: As the 1stMTPJ angle widened, the frequency distributions of identified weight-shifting patterns became increasingly lopsided, due to the favoring or disfavoring of one pattern at the expense of the other. The two sexes showed opposite trends in the weight-shifting patterns that were favored/disfavored, relative to participants with a 0 degrees 1stMTPJ angle. The clear predominance of a central-shift pattern, at the expense of a medial-shift, occurred with the largest (20 degrees) 1stMTPJ angle among girls. Additionally, the BMI distributions associated with 1stMTPJ angle characteristics showed opposite trends between the sexes. Conclusions: Valgus alignment of 1stMTPJ among adolescents were associated with limitations in weight-shifting freedom of the foot during walking, that could be involved in maintaining balance. An 1stMTPJ angle of 20 degrees, where distinct limitations were observed, might serve as a criterion of HV pathology.

Background This paper aimed to verify how a supplementation of rower’s diet with Astragalus Membranaceus Root (AMR) modulated their immune system response to maximal physical exertion. Methods The doubleblind study included 18 members of the Polish Rowing Team assigned to the supplemented group (n = 10), and the placebo group (n = 8). The participants performed a 2000 m test on a rowing ergometer at the beginning and at the end of the sixweek of intensive training camp during which the supplemented group received 500 mg of AMR. Blood samples were obtained prior to, one minute after completing, and 24 hours after the exertion test. The levels of interleukin 2 (IL2), interleukin 4 (IL4), interleukin 10 (IL10), interferon ɤ (IFNɣ), and lactate acid were determined. Subpopulations of T regulatory lymphocytes [CD4+/CD25+/CD127−] (Treg), cytotoxic lymphocytes [CD8+/TCRαβ+] (CTL), natural killer cells [CD3−/CD16+/CD56+] (NK), and TCRδγpositive cells (Tδγ) were determined with flow cytometry. Results After the camp, the initial NK and Treg levels sustained at the baseline, while Tδγ counts increased by about x [y z] % relative to the levels in the placebo group. In the supplemented subgroup, a change in IL2 level in reaction to maximal exertion clearly decreased (x [y x]%), while the change in IL2/IL10 level induced by the recovery after this exertion clearly increased (x[y z] %), relative to the changes in the placebo group. Conclusions AMR restored the immunological balance through a stabilization of NK and Treg cells with a positive trend in Tδγ towards Th1 response during restitution by cytokine IL2 modulation.