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Dr. Zhicheng Dong
Guangzhou University
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22Years (2005-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications1 August 2015 in Molecular Plant
Journal Article
XMXingliang Ma
Xingliang MaQZQunyu Zhang
Qunyu Zhang
QZQinlong Zhu
Qinlong Zhu
WLWei Liu
Wei Liu
YCYan Chen
Yan Chen
LYLiu Yaoguang
Liu Yaoguang +14
22 July 2008 in Proceedings of the National Academy of Sciences
Journal Article
The results of genetic studies in Arabidopsis indicate that three proteins, the RNase III DICER-Like1 (DCL1), the dsRNA-binding protein HYPONASTIC LEAVES1 (HYL1), and the C2H2 Zn-finger protein SERRATE (SE), are required for the accurate processing of microRNA (miRNA) precursors in the plant cell nucleus. To elucidate the biochemical mechanism of miRNA processing, we developed an in vitro miRNA processing assay using purified recombinant proteins. We find that DCL1 alone releases 21-nt short RNAs from dsRNA as well as synthetic miR167b precursor RNAs. However, correctly processed miRNAs constitute a minority of the cleavage products. We show that recombinant HYL1 and SE proteins accelerate the rate of DCL1-mediated cleavage of pre- and pri-miR167b substrates and promote accurate processing.
24 August 2017 in The EMBO Journal
Journal Article
JZJian Zeng
Jian Zeng
ZDZhicheng Dong
Zhicheng DongHWHaijun Wu
Haijun WuZTZhaoxia Tian
Zhaoxia TianZZZhong Zhao
Zhong Zhao5 October 2013 in Science China Life Sciences
Journal Article
ZDZhicheng Dong
Zhicheng DongYCYan Chen
Yan Chen
Transcriptomics is one of the most developed fields in the post-genomic era. Transcriptome is the complete set of RNA transcripts in a specific cell type or tissue at a certain developmental stage and/or under a specific physiological condition, including messenger RNA, transfer RNA, ribosomal RNA, and other non-coding RNAs. Transcriptomics focuses on the gene expression at the RNA level and offers the genome-wide information of gene structure and gene function in order to reveal the molecular mechanisms involved in specific biological processes. With the development of next-generation high-throughput sequencing technology, transcriptome analysis has been progressively improving our understanding of RNA-based gene regulatory network. Here, we discuss the concept, history, and especially the recent advances in this inspiring field of study.
29 October 2018 in Nature Plants
Journal Article
9 October 2020 in Science
Journal Article
HWHaijun Wu
Haijun WuXQXiaoya Qu
Xiaoya QuZDZhicheng Dong
Zhicheng DongLLLinjie Luo
Linjie Luo
CSChen Shao
Chen Shao
ZZZhong Zhao
Zhong Zhao +9
Building a safe space for stem cells: The meristem, the collection of stem cells that builds plants, is resistant to viral infection. Wu et al. now show that WUSCHEL, a transcription factor that helps to sustain stem cell production in the shoot apical meristem of Arabidopsis , also protects that stem cell domain from viruses. WUSCHEL inhibited viral protein synthesis by repressing methyltransferases that regulate ribosomal RNA processing and ribosome stability. Science , this issue p. 227
About Me
Publications include: Haijun Wu, Xiaoya Qu, Zhicheng Dong, Linjie Luo, Chen Shao, Joachim Forner, Jan U. Lohmann, Meng Su, Mengchu Xu, Xiaobin Liu, Lei Zhu, Jian Zeng, Sumei Liu, Zhaoxia Tian, & Zhong Zhao (2020) WUSCHEL triggers innate antiviral immunity in plant stem cells. Science 370(6513): 227-231
Min Liu #, Jiafu Zhu #, Zhicheng Dong* (2020) Immediate transcriptional responses of Arabidopsis leaves to heat shock. Journal of Integrative Plant Biology https://doi.org/10.1111/jipb.12990
Jiafu Zhu, Min Liu, Xiaobin Liu and Zhicheng Dong (2018) RNA polymerase II activity revealed by GRO-seq and pNET-seq in Arabidopsis. Nature Plants 4, 1112–1123
Jian Zeng, Zhicheng Dong, Haijun Wu, Zhaoxia Tian and Zhong Zhao* (2017) Redox regulation of plant stem cell fate. EMBO J. 36: 2844-2855
Zhicheng Dong, Meng-Hsuan Han, and Nina V. Fedoroff (2008) The RNA-binding proteins HYL1 and SE promote accurate in vitro processing of pri-miRNA by DCL1. Proc Natl Acad Sci USA 105:9970–9975
Zhi-Cheng Dong, Zhong Zhao, Cheng-wu Liu, Jiang-hong Luo, Jun Yang, Wei-hua Huang, Xiao-he Hu, Trevor L. Wang, and Da Luo (2005) Floral patterning in Lotus japonicus. Plant Physiology 137(4):1272-82