Intimate mixtures of trembling aspen (Populus tremuloides Michx.) and white spruce (Picea glauca (Moench) Voss) are a key feature of western Canadian boreal forests. These mixtures have the potential to produce high yields of merchantable fibre and provide numerous ecological services. Achievement of this potential has been difficult, and often expensive, to realize as a regeneration goal in managed forests. We report 21 to 25 year results of managed mixtures on two study sites where the white spruce was planted, and the density of aspen natural regeneration manipulated within five years of the stand initiation disturbance. On both sites, white spruce mortality did not increase with increasing aspen density. While height and diameter growth of white spruce declined with increasing aspen density, the effect was not entirely consistent across the two sites. Abrasion from aspen branches was the most common source of damage to spruce crowns. Mixed stands had greater merchantable volume production than pure spruce stands based on model projections. Application of aspen harvest at year 60, while protecting the spruce component for a second harvest entry at year 90, was projected to optimize combined yield for the mixedwood stands.