Marcia Margis-Pinheiro

Dr. Marcia Margis-Pinheiro

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Research Focus & Metrics

Academic Career Length

36Years (1991-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 January 2012 in Genetics and Molecular Biology
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Journal Article
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ACAndréia Caverzan
Andréia Caverzan
GPGisele Passaia
Gisele Passaia
SRSilvia Barcellos Rosa
Silvia Barcellos Rosa
CRCarolina Werner Ribeiro
Carolina Werner Ribeiro
FLFernanda Lazzarotto
Fernanda Lazzarotto
MMMarcia Margis-Pinheiro
Marcia Margis-Pinheiro
When plants are exposed to stressful environmental conditions, the production of Reactive Oxygen Species (ROS) increases and can cause significant damage to the cells. Antioxidant defenses, which can detoxify ROS, are present in plants. A major hydrogen peroxide detoxifying system in plant cells is the ascorbate-glutathione cycle, in which, ascorbate peroxidase (APX) enzymes play a key role catalyzing the conversion of H(2)O(2) into H(2)O, using ascorbate as a specific electron donor. Different APX isoforms are present in distinct subcellular compartments, such as chloroplasts, mitochondria, peroxisome, and cytosol. The expression of APX genes is regulated in response to biotic and abiotic stresses as well as during plant development. The APX responses are directly involved in the protection of plant cells against adverse environmental conditions. Furthermore, mutant plants APX genes showed alterations in growth, physiology and antioxidant metabolism revealing those enzymes involvement in the normal plant development.

11 July 2008 in The FEBS Journal
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RMRogerio Margis
Rogerio Margis
DCDunand Christophe
Dunand Christophe
FTFelipe K. Teixeira
Felipe K. Teixeira
MMMarcia Margis-Pinheiro
Marcia Margis-Pinheiro

10 April 2017 in Genetics and Molecular Biology
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Journal Article
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LBLauro Bücker-Neto
Lauro Bücker-Neto
APAna Luiza Sobral Paiva
Ana Luiza Sobral Paiva
RMRonei Dorneles Machado
Ronei Dorneles Machado
RARafael Augusto Arenhart
Rafael Augusto Arenhart
MMMarcia Margis-Pinheiro
Marcia Margis-Pinheiro
Heavy metals are natural non-biodegradable constituents of the Earth's crust that accumulate and persist indefinitely in the ecosystem as a result of human activities. Since the industrial revolution, the concentration of cadmium, arsenic, lead, mercury and zinc, amongst others, have increasingly contaminated soil and water resources, leading to significant yield losses in plants. These issues have become an important concern of scientific interest. Understanding the molecular and physiological responses of plants to heavy metal stress is critical in order to maximize their productivity. Recent research has extended our view of how plant hormones can regulate and integrate growth responses to various environmental cues in order to sustain life. In the present review we discuss current knowledge about the role of the plant growth hormones abscisic acid, auxin, brassinosteroid and ethylene in signaling pathways, defense mechanisms and alleviation of heavy metal toxicity.

31 January 2013 in The FEBS Journal
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JAJoão Braga de Abreu‐Neto
João Braga de Abreu‐Neto
ATAndreia C. Turchetto‐Zolet
Andreia C. Turchetto‐Zolet
LOLuiz Felipe Valter de Oliveira
Luiz Felipe Valter de Oliveira
MZMaria Helena Bodanese Zanettini
Maria Helena Bodanese Zanettini
MMMarcia Margis-Pinheiro
Marcia Margis-Pinheiro
Metallochaperones are key proteins for the safe transport of metallic ions inside the cell. HIPPs (heavy metal‐associated isoprenylated plant proteins) are metallochaperones that contain a metal binding domain (HMA) and a C–terminal isoprenylation motif. In this study, we provide evidence that proteins of this family are found only in vascular plants and may be separated into five distinct clusters. HIPPs may be involved in (a) heavy metal homeostasis and detoxification mechanisms, especially those involved in cadmium tolerance, (b) transcriptional responses to cold and drought, and (c) plant–pathogen interactions. In particular, our results show that the rice (Oryza sativa) HIPP OsHIPP41 gene is highly expressed in response to cold and drought stresses, and its product is localized in the cytosol and the nucleus. The results suggest that HIPPs play an important role in the development of vascular plants and in plant responses to environmental changes.

1 June 2007 in Phytochemistry
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Journal Article
Closed access
FPFilippo Passardi
Filippo Passardi
GTGrégory Theiler
Grégory Theiler
Marcel ZamockyMarcel Zamocky
Marcel Zamocky
Claudia CosioClaudia Cosio
Claudia Cosio
Nicolas RouhierNicolas Rouhier
Nicolas Rouhier
DCDunand Christophe
Dunand Christophe

6 January 2006 in Planta
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Journal Article
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FTFelipe Karam Teixeira
Felipe Karam Teixeira
LMLarissa Menezes-Benavente
Larissa Menezes-Benavente
VGVinicius Costa Galvão
Vinicius Costa Galvão
RMRogério Margis
Rogério Margis
MMMarcia Margis-Pinheiro
Marcia Margis-Pinheiro