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Development of elastin-like polypeptide (ELP) biomaterials is widespread, but information critical for clinical deployment is limited, with biocompatibility studies focused on a narrow cross-section of ELP sequences. Macrophages can impair biomaterial systems by degrading or isolating the biomaterial and by activating additional immune functions. Their phagocytic response will reveal early immune biocompatibility of ELP nanoparticles (NPs). This study examines that response, induced by the adsorbed protein corona, as a function of ELP guest amino acid, chain length and NP diameter. The breadth of proteins adsorbed to ELP NPs varied, with valine-containing ELP NPs adsorbing fewer types of proteins than leucine-containing constructs. Particle diameter was also a factor, with smaller leucine-containing ELP NPs adsorbing the broadest range of proteins. Macrophage viability was unaffected by the ELP NPs, and their phagocytic capabilities were unimpeded except when incubated with a 500 nm valine-containing 40-mer. This NP significantly decreased the phagocytic capacity of macrophages relative to the control and to a corresponding 500 nm leucine-containing 40-mer. NP size and the proportion of opsonin to dysopsonin proteins likely influenced this outcome. These results suggest that certain combinations of ELP sequence and particle size can result in an adsorbed protein corona, which may hinder macrophage function.
Markian S. Bahniuk; Van A. Ortega; Abdullah K. Alshememry; James L. Stafford; Greg G. Goss; Larry D. Unsworth. Effect of amino acid composition of e lastin‐like polypeptide nanoparticles on nonspecific protein adsorption, macrophage cell viability and phagocytosis. Biopolymers 2021, e23468 .
AMA StyleMarkian S. Bahniuk, Van A. Ortega, Abdullah K. Alshememry, James L. Stafford, Greg G. Goss, Larry D. Unsworth. Effect of amino acid composition of e lastin‐like polypeptide nanoparticles on nonspecific protein adsorption, macrophage cell viability and phagocytosis. Biopolymers. 2021; ():e23468.
Chicago/Turabian StyleMarkian S. Bahniuk; Van A. Ortega; Abdullah K. Alshememry; James L. Stafford; Greg G. Goss; Larry D. Unsworth. 2021. "Effect of amino acid composition of e lastin‐like polypeptide nanoparticles on nonspecific protein adsorption, macrophage cell viability and phagocytosis." Biopolymers , no. : e23468.
We examined goldfish immunotoxicological responses to intravenously injected PAA-TiO2 NPs by determining organ accumulation, depuration, tissue damage, and immune responsiveness in the kidneys, spleen, and isolated primary kidney neutrophils.
Van A. Ortega; David Boyle; Jordan W. Hodgkinson; Denina B. D. Simmons; Miodrag Belosevic; James L. Stafford; Greg G. Goss. Polymer-coated TiO2 nanoparticles bioaccumulate, immunoactivate and suppress pathogenic Mycobacterium chelonae clearance when intravenously injected into goldfish (Carassius auratus L.). Environmental Science: Nano 2021, 1 .
AMA StyleVan A. Ortega, David Boyle, Jordan W. Hodgkinson, Denina B. D. Simmons, Miodrag Belosevic, James L. Stafford, Greg G. Goss. Polymer-coated TiO2 nanoparticles bioaccumulate, immunoactivate and suppress pathogenic Mycobacterium chelonae clearance when intravenously injected into goldfish (Carassius auratus L.). Environmental Science: Nano. 2021; ():1.
Chicago/Turabian StyleVan A. Ortega; David Boyle; Jordan W. Hodgkinson; Denina B. D. Simmons; Miodrag Belosevic; James L. Stafford; Greg G. Goss. 2021. "Polymer-coated TiO2 nanoparticles bioaccumulate, immunoactivate and suppress pathogenic Mycobacterium chelonae clearance when intravenously injected into goldfish (Carassius auratus L.)." Environmental Science: Nano , no. : 1.
Global flaring volume exceeds 140 billion m3 annually and flares are a key source of particulate air pollution. During flowback operations subsequent to fracturing of a well, droplets of flowback water—with varying levels of dissolved salts—can be entrained in the flared gas. Despite the widespread prevalence of fracturing, very little is known about the properties of particle emissions from such flares. To study these properties, we used a laboratory pipe flare producing a turbulent diffusion flame without and with entrained droplets. Entrained droplets of deionized water, sodium chloride solution, and solutions representing two typical flowback waters in Canada (Cardium and Duvernay) were used. Three different gas compositions (consisting of C1 to C7 alkanes, carbon dioxide, and nitrogen) representative of flares in the upstream oil and gas sector in Alberta, Canada were studied. The results showed that the salt in the entrained flowback droplets increased the particle concentration by about one order of magnitude by forming freshly nucleated salt particles. Moreover, soot concentration increased as a result of entrained salt. Effective density results showed that small particles (300 nm) were mostly soot—a result also confirmed by transmission electron microscopy (TEM). Electron micrographs showed that the majority of particles were either individual salt particles or internally-mixed soot-salt particles. The inorganic salt particles mainly consisted of Na and Cl, the two most abundant elements in flowback water. Raman spectroscopy indicated that the salt had much less (or no) impact on graphitic nanostructure of soot, while the fuel blend had a significant effect. The results of this study are significant as they reveal that current emission inventories based on flaring of gases only may underestimate soot emissions from flares with entrained droplets.
Mohsen Kazemimanesh; Alberto Baldelli; Una Trivanovic; Olga Popovicheva; Mikhail Timofeev; Natalia Shonija; Yuri Obvintsev; Chen Kuang; A. Melina Jefferson; Joel C. Corbin; Greg G. Goss; Daniel S. Alessi; Matthew R. Johnson; Steven N. Rogak; Jason S. Olfert. Particulate emissions from turbulent diffusion flames with entrained droplets: A laboratory simulation of gas flaring emissions. Journal of Aerosol Science 2021, 157, 105807 .
AMA StyleMohsen Kazemimanesh, Alberto Baldelli, Una Trivanovic, Olga Popovicheva, Mikhail Timofeev, Natalia Shonija, Yuri Obvintsev, Chen Kuang, A. Melina Jefferson, Joel C. Corbin, Greg G. Goss, Daniel S. Alessi, Matthew R. Johnson, Steven N. Rogak, Jason S. Olfert. Particulate emissions from turbulent diffusion flames with entrained droplets: A laboratory simulation of gas flaring emissions. Journal of Aerosol Science. 2021; 157 ():105807.
Chicago/Turabian StyleMohsen Kazemimanesh; Alberto Baldelli; Una Trivanovic; Olga Popovicheva; Mikhail Timofeev; Natalia Shonija; Yuri Obvintsev; Chen Kuang; A. Melina Jefferson; Joel C. Corbin; Greg G. Goss; Daniel S. Alessi; Matthew R. Johnson; Steven N. Rogak; Jason S. Olfert. 2021. "Particulate emissions from turbulent diffusion flames with entrained droplets: A laboratory simulation of gas flaring emissions." Journal of Aerosol Science 157, no. : 105807.
Elijah Joel Petersen; Greg Gerard Goss; Frank von der Kammer; Alan James Kennedy. New guidance brings clarity to environmental hazard and behaviour testing of nanomaterials. Nature Nanotechnology 2021, 16, 482 -483.
AMA StyleElijah Joel Petersen, Greg Gerard Goss, Frank von der Kammer, Alan James Kennedy. New guidance brings clarity to environmental hazard and behaviour testing of nanomaterials. Nature Nanotechnology. 2021; 16 (5):482-483.
Chicago/Turabian StyleElijah Joel Petersen; Greg Gerard Goss; Frank von der Kammer; Alan James Kennedy. 2021. "New guidance brings clarity to environmental hazard and behaviour testing of nanomaterials." Nature Nanotechnology 16, no. 5: 482-483.
Correction for ‘Potentiation of polycyclic aromatic hydrocarbon uptake in zebrafish embryos by nanoplastics’ by Yueyang Zhang et al., Environ. Sci.: Nano, 2020, 7, 1730–1741, DOI: 10.1039/D0EN00163E.
Yueyang Zhang; Greg G. Goss. Correction: Potentiation of polycyclic aromatic hydrocarbon uptake in zebrafish embryos by nanoplastics. Environmental Science: Nano 2021, 8, 1481 -1481.
AMA StyleYueyang Zhang, Greg G. Goss. Correction: Potentiation of polycyclic aromatic hydrocarbon uptake in zebrafish embryos by nanoplastics. Environmental Science: Nano. 2021; 8 (5):1481-1481.
Chicago/Turabian StyleYueyang Zhang; Greg G. Goss. 2021. "Correction: Potentiation of polycyclic aromatic hydrocarbon uptake in zebrafish embryos by nanoplastics." Environmental Science: Nano 8, no. 5: 1481-1481.
Benzophenones are widely used as organic UV filters in many personal care products, especially sunscreen, to protect humans from UV radiation. The increasing use of benzophenone class UV filters has raised concerns about the potential effects on the aquatic environment. These organic UV filters are designed to absorb UV light. However, to date, studies have not considered the potential of UV light to potentiate the toxicity of benzophenones in aquatic organisms. In this study using zebrafish embryos, we assessed the median lethal concentration (LC50) and sub-lethal effects of benzophenone and oxybenzone either under natural levels of UV light or under laboratory light conditions. The LC50 value in zebrafish embryos under both light conditions of oxybenzone was lower when compared to benzophenone. Interestingly, UV light significantly decreased the LC50 values (increased toxicity) of both benzophenone and oxybenzone. The presence of UV light induced a significant increase in hydroxyl radical formation and this was reflected in both increased SOD activity and lipid peroxidation in oxybenzone treated groups. Exposure to either benzophenone or oxybenzone also delayed hatching between 60 and 96 hpf when comparing to the control group while UV exposure further delayed hatching only in oxybenzone-exposed embryos. The results demonstrate the importance of involving UV light in toxicity testing for UV filters and provide much-need information on the UV-induced toxicity of benzophenone and oxybenzone under ecologically realistic conditions.
Yueyang Zhang; Prachi Shah; Fan Wu; Peipei Liu; Jing You; Greg Goss. Potentiation of lethal and sub-lethal effects of benzophenone and oxybenzone by UV light in zebrafish embryos. Aquatic Toxicology 2021, 235, 105835 .
AMA StyleYueyang Zhang, Prachi Shah, Fan Wu, Peipei Liu, Jing You, Greg Goss. Potentiation of lethal and sub-lethal effects of benzophenone and oxybenzone by UV light in zebrafish embryos. Aquatic Toxicology. 2021; 235 ():105835.
Chicago/Turabian StyleYueyang Zhang; Prachi Shah; Fan Wu; Peipei Liu; Jing You; Greg Goss. 2021. "Potentiation of lethal and sub-lethal effects of benzophenone and oxybenzone by UV light in zebrafish embryos." Aquatic Toxicology 235, no. : 105835.
Freshwater fishes maintain an internal osmolality of ~300 mOsm, while living in dilute environments ranging from 0 to 50 mOsm. This osmotic challenge is met at least partially, by Na+/H+ exchangers (NHE) of fish gill and kidney. In this study, we cloned, expressed, and pharmacologically characterized fish-specific Nhes of the commercially important species Oncorhynchus mykiss. Trout (t) Nhe3a and Nhe3b isoforms from gill and kidney were expressed and characterized in an NHE-deficient cell line. Western blotting and immunocytochemistry confirmed stable expression of the tagged trout tNhe proteins. To measure NHE activity, a transient acid load was induced in trout tNhe expressing cells and intracellular pH was measured. Both isoforms demonstrated significant activity and recovered from an acute acid load. The effect of the NHE transport inhibitors amiloride, EIPA (5-(N-ethyl-N-isopropyl)-amiloride), phenamil, and DAPI was examined. tNhe3a was inhibited in a dose-dependent manner by amiloride and EIPA and tNhe3a was more sensitive to amiloride than EIPA, unlike mammalian NHE1. tNhe3b was inhibited by high concentrations of amiloride, while even in the presence of high concentrations of EIPA (500 µM), some activity of tNhe3b remained. Phenamil and DAPI were ineffective at inhibiting tNhe activity of either isoform. The current study aids in understanding the pharmacology of fish ion transporters. Both isoforms display inhibitory profiles uniquely different from mammalian NHEs and show resistance to inhibition. Our study allows for more direct interpretation of past, present, and future fish-specific sodium transport studies, with less reliance on mammalian NHE data for interpretation.
Salvatore Blair; Xiuju Li; Debajyoti Dutta; Danuta Chamot; Larry Fliegel; Greg Goss. Rainbow Trout (Oncorhynchus mykiss) Na+/H+ Exchangers tNhe3a and tNhe3b Display Unique Inhibitory Profiles Dissimilar from Mammalian NHE Isoforms. International Journal of Molecular Sciences 2021, 22, 2205 .
AMA StyleSalvatore Blair, Xiuju Li, Debajyoti Dutta, Danuta Chamot, Larry Fliegel, Greg Goss. Rainbow Trout (Oncorhynchus mykiss) Na+/H+ Exchangers tNhe3a and tNhe3b Display Unique Inhibitory Profiles Dissimilar from Mammalian NHE Isoforms. International Journal of Molecular Sciences. 2021; 22 (4):2205.
Chicago/Turabian StyleSalvatore Blair; Xiuju Li; Debajyoti Dutta; Danuta Chamot; Larry Fliegel; Greg Goss. 2021. "Rainbow Trout (Oncorhynchus mykiss) Na+/H+ Exchangers tNhe3a and tNhe3b Display Unique Inhibitory Profiles Dissimilar from Mammalian NHE Isoforms." International Journal of Molecular Sciences 22, no. 4: 2205.
Hydraulic fracturing has become widely used in recent years to access vast global unconventional sources of oil and gas. This process involves the injection of proprietary mixtures of water and chemicals to fracture shale formations and extract the hydrocarbons trapped within. These injection fluids, along with minerals, hydrocarbons, and saline waters present within the formations being drilled into, return to the surface as flowback and produced water (FPW). FPW is a highly complex mixture, containing metals, salts and clay, as well as many organic chemicals, including polycyclic aromatic hydrocarbons such as phenanthrene. The present study sought to determine the effects of temperature on the accumulation of phenanthrene in rainbow trout (Oncorhynchus mykiss). This model organism resides in rivers overlapping the Montney and Duvernay formations, both highly developed formations for hydraulic fracturing. Rainbow trout acclimated to temperatures of 4, 13 and 17 °C were exposed to either 5% or 20% FPW, as well as saline mixtures representing the exact ionic content of FPW to determine the accumulation of radiolabelled 14C phenanthrene within the gill, gut, liver and gallbladder. FPW exposure reduced the overall accumulation of phenanthrene in a manner most often similar to high salinity exposure, indicating that the high ionic strength of FPW is the primary factor affecting accumulation. Accumulation was different at the temperature extremes (4 and 17 °C), although no consistent relationship was observed between temperature and accumulation across the observed tissues. These results indicate that several physiological responses occur as a result of FPW exposure and water temperature change which dictate phenanthrene uptake, particularly in the gills. Temperature (and seasonality) alone cannot be used to model the potential accumulation of polycyclic aromatic hydrocarbons after FPW spills.
Tamzin A. Blewett; Aaron Boyd; Erik J. Folkerts; Katherine N. Snihur; Daniel S. Alessi; Greg Goss. Effect of temperature on phenanthrene accumulation from hydraulic fracturing flowback and produced water in rainbow trout (Oncorhynchus mykiss). Environmental Pollution 2020, 272, 116411 .
AMA StyleTamzin A. Blewett, Aaron Boyd, Erik J. Folkerts, Katherine N. Snihur, Daniel S. Alessi, Greg Goss. Effect of temperature on phenanthrene accumulation from hydraulic fracturing flowback and produced water in rainbow trout (Oncorhynchus mykiss). Environmental Pollution. 2020; 272 ():116411.
Chicago/Turabian StyleTamzin A. Blewett; Aaron Boyd; Erik J. Folkerts; Katherine N. Snihur; Daniel S. Alessi; Greg Goss. 2020. "Effect of temperature on phenanthrene accumulation from hydraulic fracturing flowback and produced water in rainbow trout (Oncorhynchus mykiss)." Environmental Pollution 272, no. : 116411.
The Advanced Oxidation System (AOS) is a novel electrochemical advanced oxidation process that effectively removes bacterial and organic contaminants from wastewater. However, potential formation of secondary oxidative species may pose additional hazards to aquatic organisms living in the receiving water affected by the post-treatment effluent. The effect of exposure to AOS treated water, especially the potential long-term effects on aquatic organisms, requires further investigation to demonstrate both efficacy and safety of this process. To examine the potential adverse effects of AOS treated water, three aquatic species, including daphnia, zebrafish, and rainbow trout, were exposed to treated and untreated municipal wastewater effluent (MWE) spiked with one of two model organic contaminants, benzo[a]pyrene (BaP) and 17β-estradiol (E2). The results indicated AOS treatment significantly reduced the adverse effects caused by exposure to MWE and model organic contaminants to baseline levels in daphnia (reduced fecundity), zebrafish embryo (elevated EROD activity), and rainbow trout (elevated plasma vitellogenin). The Ames test was also conducted to confirm the removal efficacy of carcinogenicity of BaP spiked in MWE. Overall, this study demonstrated that AOS treatment is a promising and environmentally friendly technology for wastewater treatment, remediation, and management.
Yuhe He; Laura Patterson-Fortin; Jenny Boutros; Richard Smith; Greg G. Goss. Removal of biological effects of organic pollutants in municipal wastewater by a novel advanced oxidation system. Journal of Environmental Management 2020, 280, 111855 .
AMA StyleYuhe He, Laura Patterson-Fortin, Jenny Boutros, Richard Smith, Greg G. Goss. Removal of biological effects of organic pollutants in municipal wastewater by a novel advanced oxidation system. Journal of Environmental Management. 2020; 280 ():111855.
Chicago/Turabian StyleYuhe He; Laura Patterson-Fortin; Jenny Boutros; Richard Smith; Greg G. Goss. 2020. "Removal of biological effects of organic pollutants in municipal wastewater by a novel advanced oxidation system." Journal of Environmental Management 280, no. : 111855.
Publicly available toxicological studies on wastewaters associated with unconventional oil and gas (UOG) activities in offshore regions are nonexistent. The current study investigated the impact of hydraulic fracturing-generated flowback water (HF-FW) on whole organism swimming performance/respiration and cardiomyocyte contractility dynamics in mahi-mahi (Coryphaena hippurus-hereafter referred to as "mahi"), an organism which inhabits marine ecosystems where offshore hydraulic fracturing activity is intensifying. Following exposure to 2.75% HF-FW for 24 h, mahi displayed significantly reduced critical swimming speeds (Ucrit) and aerobic scopes (reductions of ∼40 and 61%, respectively) compared to control fish. Additionally, cardiomyocyte exposures to the same HF-FW sample at 2% dilutions reduced a multitude of mahi sarcomere contraction properties at various stimulation frequencies compared to all other treatment groups, including an approximate 40% decrease in sarcomere contraction size and a nearly 50% reduction in sarcomere relaxation velocity compared to controls. An approximate 8-fold change in expression of the cardiac contractile regulatory gene cmlc2 was also seen in ventricles from 2.75% HF-FW-exposed mahi. These results collectively identify cardiac function as a target for HF-FW toxicity and provide some of the first published data on UOG toxicity in a marine species.
Erik J. Folkerts; Rachael M. Heuer; Shannon Flynn; John D. Stieglitz; Daniel D. Benetti; Daniel S. Alessi; Greg G. Goss; Martin Grosell. Exposure to Hydraulic Fracturing Flowback Water Impairs Mahi-Mahi (Coryphaena hippurus) Cardiomyocyte Contractile Function and Swimming Performance. Environmental Science & Technology 2020, 54, 13579 -13589.
AMA StyleErik J. Folkerts, Rachael M. Heuer, Shannon Flynn, John D. Stieglitz, Daniel D. Benetti, Daniel S. Alessi, Greg G. Goss, Martin Grosell. Exposure to Hydraulic Fracturing Flowback Water Impairs Mahi-Mahi (Coryphaena hippurus) Cardiomyocyte Contractile Function and Swimming Performance. Environmental Science & Technology. 2020; 54 (21):13579-13589.
Chicago/Turabian StyleErik J. Folkerts; Rachael M. Heuer; Shannon Flynn; John D. Stieglitz; Daniel D. Benetti; Daniel S. Alessi; Greg G. Goss; Martin Grosell. 2020. "Exposure to Hydraulic Fracturing Flowback Water Impairs Mahi-Mahi (Coryphaena hippurus) Cardiomyocyte Contractile Function and Swimming Performance." Environmental Science & Technology 54, no. 21: 13579-13589.
There is limited information regarding the toxicity of the trace element thallium (Tl) to aquatic biota, most of which assesses acute toxicity and bioaccumulation. The relative lack of chronic Tl toxicity data compromises the establishment of water quality criteria for this trace metal. In the presented work, chronic toxicity endpoints (final body weight (a proxy measure of growth), survival, and reproduction) and Tl body burden were measured in the freshwater crustacean Daphnia magna during a 21-day exposure to dissolved Tl. Thallium caused complete mortality in daphnids between exposure concentrations of 424 and 702 μg L-1. In contrast with previously published work examining acute Tl toxicity, exposure to Tl for 21 days was not associated with changes in whole-body potassium concentration. This was despite a 710-fold increase in Tl body burden in animals exposed to 424 μg L-1 relative to the control. Median effect concentrations (EC50’s) for growth and reproduction (total neonates produced), were 1.6 (95% confidence interval: 1.0 – 3.1) and 11.1 (95% confidence interval: 5.5 – 21.8) μg Tl L-1, respectively. A no observable effect concentration (NOEC) of 0.9 μg Tl L-1 for growth, and a NOEC range of 0.9 to 83 μg Tl L-1 for a variety of reproductive metrics, was measured. A lowest observable effect concentration (LOEC) of 8.8 μg Tl L-1 was determined for the effects of Tl on growth and most of the reproductive endpoints examined. These data indicate that under controlled laboratory conditions D. magna is significantly less sensitive to Tl than the species on which the current Canadian Council of Ministers of the Environment regulatory guideline value of 0.8 μg L-1 is based.
Andrew H. Nagel; Chad W. Cuss; Greg G. Goss; William Shotyk; Chris N. Glover. Chronic toxicity of waterborne thallium to Daphnia magna. Environmental Pollution 2020, 268, 115776 .
AMA StyleAndrew H. Nagel, Chad W. Cuss, Greg G. Goss, William Shotyk, Chris N. Glover. Chronic toxicity of waterborne thallium to Daphnia magna. Environmental Pollution. 2020; 268 ():115776.
Chicago/Turabian StyleAndrew H. Nagel; Chad W. Cuss; Greg G. Goss; William Shotyk; Chris N. Glover. 2020. "Chronic toxicity of waterborne thallium to Daphnia magna." Environmental Pollution 268, no. : 115776.
Nanoparticles (NPs) that are exposed to blood are coated with an assortment of proteins that establish their biological identity by forming the interface between the NP and the cells and tissues of the body. The biological relevance of this protein corona is often overlooked during toxicological assessments of NPs. However, accurate interpretation of biological outcomes following exposure to NPs, including activation of coagulation, opsonization of pathogens, and cellular phagocytosis, must take this adsorbed proteome into account. In this study, we examined protein coronas on the surface of five poly(acrylic acid) (PAA) metal-oxide NPs (TiO2, CeO2, Fe2O3, ZnO, and PAA-capsules) following exposure to human plasma for key markers of various host response pathways, including humoral immunity and coagulation. We also evaluated the impacts of pre-exposing serum proteins to PAA-NPs on the opsonization and phagocytosis of bacteria by two immune cell lines. Results demonstrated that each PAA-NP type adsorbed a unique profile of blood proteins and that protein-coated PAA-NPs significantly inhibited human plasma coagulation with PAA-zinc oxide NPs and their associated proteome fully abrogating clotting. Protein-coated PAA-NPs also resulted in a 50% increase in phagocytic activity of RBL-2H3 cells and a 12.5% increase in phagocytic activity in the RAW 264.7 cell line. We also identified numerous structural, coagulation, and immune-activating proteins in the adsorbed protein corona, which resulted in altered biological function. Overall, our findings demonstrate that the formation of protein coronas on the surface of NPs plays an important role in directing the biological outcomes of opsonization, cell phagocytosis, and blood coagulation.
Van A. Ortega; Markian S. Bahniuk; Sharyar Memon; Larry D. Unsworth; James L. Stafford; Greg G. Goss. Polymer-coated nanoparticle protein corona formation potentiates phagocytosis of bacteria by innate immune cells and inhibits coagulation in human plasma. Biointerphases 2020, 15, 051003 .
AMA StyleVan A. Ortega, Markian S. Bahniuk, Sharyar Memon, Larry D. Unsworth, James L. Stafford, Greg G. Goss. Polymer-coated nanoparticle protein corona formation potentiates phagocytosis of bacteria by innate immune cells and inhibits coagulation in human plasma. Biointerphases. 2020; 15 (5):051003.
Chicago/Turabian StyleVan A. Ortega; Markian S. Bahniuk; Sharyar Memon; Larry D. Unsworth; James L. Stafford; Greg G. Goss. 2020. "Polymer-coated nanoparticle protein corona formation potentiates phagocytosis of bacteria by innate immune cells and inhibits coagulation in human plasma." Biointerphases 15, no. 5: 051003.
Cane toad iliac arteries were perfused ex vivo with polyacrylic acid coated nanoparticles. Nanoparticle uptake was observed in both endothelial and vascular smooth muscle cells, eliciting endothelial cell apoptosis and diminished vascular relaxation.
Van A. Ortega; Melissa S. Cameron; James L. Stafford; Greg G. Goss; John A. Donald; Aaron G. Schultz. Polyacrylic acid coated nanoparticles elicit endothelial cell apoptosis and diminish vascular relaxation in ex vivo perfused iliac arteries of the cane toad (Rhinella marina). Environmental Science: Nano 2020, 7, 1912 -1926.
AMA StyleVan A. Ortega, Melissa S. Cameron, James L. Stafford, Greg G. Goss, John A. Donald, Aaron G. Schultz. Polyacrylic acid coated nanoparticles elicit endothelial cell apoptosis and diminish vascular relaxation in ex vivo perfused iliac arteries of the cane toad (Rhinella marina). Environmental Science: Nano. 2020; 7 (7):1912-1926.
Chicago/Turabian StyleVan A. Ortega; Melissa S. Cameron; James L. Stafford; Greg G. Goss; John A. Donald; Aaron G. Schultz. 2020. "Polyacrylic acid coated nanoparticles elicit endothelial cell apoptosis and diminish vascular relaxation in ex vivo perfused iliac arteries of the cane toad (Rhinella marina)." Environmental Science: Nano 7, no. 7: 1912-1926.
Variance in stream temperature from historical norms, which reflects the impacts from both hydrological and meteorological factors, is a significant indicator of the stream ecosystem health. Therefore, it is imperative to study the hydrological processes controlling stream temperature in the watershed. The impacts of hydrological processes on stream temperature in the cold region of Western Canada were investigated based on the previously developed Soil and Water Assessment Tool (SWAT) equilibrium temperature model. The model was calibrated and validated for streamflow and stream temperature based on the observations and a global parameter sensitivity analysis conducted to identify the most important hydrological process governing the stream temperature dynamics. The precipitation and air temperature lapse rates were found to be the most sensitive parameters controlling the stream temperature, followed by the parameters regulating the processes of soil water dynamics, surface runoff, and channel routing. Our analysis showed an inverse relationship between streamflow volume and stream temperature, and different runoff components have different impacts on temporal regimes of stream temperatures. This study elaborates on the response of the stream temperature to changes in hydrological processes at the watershed scale and indicates that hydrological processes should be taken into account for prediction of stream temperatures.
Xinzhong Du; Greg Goss; Monireh Faramarzi. Impacts of Hydrological Processes on Stream Temperature in a Cold Region Watershed Based on the SWAT Equilibrium Temperature Model. Water 2020, 12, 1112 .
AMA StyleXinzhong Du, Greg Goss, Monireh Faramarzi. Impacts of Hydrological Processes on Stream Temperature in a Cold Region Watershed Based on the SWAT Equilibrium Temperature Model. Water. 2020; 12 (4):1112.
Chicago/Turabian StyleXinzhong Du; Greg Goss; Monireh Faramarzi. 2020. "Impacts of Hydrological Processes on Stream Temperature in a Cold Region Watershed Based on the SWAT Equilibrium Temperature Model." Water 12, no. 4: 1112.
The presence of microplastics in the environment and their potential effects on the health of organisms are a subject of great concern.
Yueyang Zhang; Greg G. Goss. Potentiation of polycyclic aromatic hydrocarbon uptake in zebrafish embryos by nanoplastics. Environmental Science: Nano 2020, 7, 1730 -1741.
AMA StyleYueyang Zhang, Greg G. Goss. Potentiation of polycyclic aromatic hydrocarbon uptake in zebrafish embryos by nanoplastics. Environmental Science: Nano. 2020; 7 (6):1730-1741.
Chicago/Turabian StyleYueyang Zhang; Greg G. Goss. 2020. "Potentiation of polycyclic aromatic hydrocarbon uptake in zebrafish embryos by nanoplastics." Environmental Science: Nano 7, no. 6: 1730-1741.
The response of microbial communities to releases of hydraulic fracturing flowback and produced water (PW) may influence ecosystem functions. However, knowledge of the effects of PW spills on freshwater microbiota is limited. Here, we conducted two separate experiments: 16S rRNA gene sequencing combined with random forests modelling was used to assess freshwater community changes in simulated PW spills by volume from 0.05% to 50%. In a separate experiment, live/dead cell viability in a freshwater community was tested during exposure to 10% PW by volume. Three distinct patterns of microbial community shifts were identified: (i) indigenous freshwater genera remained dominant in <2.5% PW, (ii) from 2.5% to 5% PW, potential PW organic degraders such as Pseudomonas, Rheinheimera and Brevundimonas became dominant, and (iii) no significant change in the relative abundance of taxa was observed in >5% PW. Microbial taxa including less abundant genera such as Cellvibrio were potential bioindicators for the degree of contamination with PW. Additionally, live cells were quickly damaged by adding 10% PW, but cell counts recovered in the following days. Our study shows that the responses of freshwater microbiota vary by spill size, and these responses show promise as effective fingerprints for PW spills in aquatic environments.
Cheng Zhong; Camilla L Nesbø; Greg G Goss; Brian D Lanoil; Daniel Alessi. Response of aquatic microbial communities and bioindicator modelling of hydraulic fracturing flowback and produced water. FEMS Microbiology Ecology 2020, 96, 1 .
AMA StyleCheng Zhong, Camilla L Nesbø, Greg G Goss, Brian D Lanoil, Daniel Alessi. Response of aquatic microbial communities and bioindicator modelling of hydraulic fracturing flowback and produced water. FEMS Microbiology Ecology. 2020; 96 (5):1.
Chicago/Turabian StyleCheng Zhong; Camilla L Nesbø; Greg G Goss; Brian D Lanoil; Daniel Alessi. 2020. "Response of aquatic microbial communities and bioindicator modelling of hydraulic fracturing flowback and produced water." FEMS Microbiology Ecology 96, no. 5: 1.
The use of nanotechnology to enhance pesticide formulations holds the promise of reduced pesticide use, reduced mobility in soils, and overall improvements in agricultural practices while simultaneously maintaining yields. However, the toxicity of nano-enabled pesticides, including azoxystrobin (Az), has not been well studied compared with their conventional form. This study investigates both lethal and sub-lethal endpoints in zebrafish embryos up to 120 h post-fertilization (hpf) under either laboratory light or simulated UV light. The median lethal concentration (LC50) value of nano-enabled Az (nAz) was significantly lower than the conventional form (Az). Interestingly, artificial UV light significantly increased toxicity (decreased LC50) of both Az and nAz. Malformations were not observed but the remaining yolk sac volume was significantly increased in both types of Az at both light conditions. This decreased yolk consumption is in agreement with reduced oxygen consumption and heart rate. Catalase enzyme activity was only reduced to UV light while superoxide dismutase activity was significantly reduced by co-exposure of UV light, and either type of Az at a nominal concentration of 100 μg L−1. The co-exposure of Az at 100 μg L−1 and UV light significantly upregulated sod1, sod2, and gpx1b expression and both types of Az significantly reduced gpx1a expression. Lipid peroxidation was significantly increased in nAz and Az at 100 μg L−1 under laboratory light, while UV light induced even higher level of lipid peroxidation. The results will provide important information on the toxicity of nAz under ecologically realistic conditions.
Yueyang Zhang; Claudia Sheedy; Denise Nilsson; Greg G. Goss. Evaluation of interactive effects of UV light and nano encapsulation on the toxicity of azoxystrobin on zebrafish. Nanotoxicology 2019, 14, 232 -249.
AMA StyleYueyang Zhang, Claudia Sheedy, Denise Nilsson, Greg G. Goss. Evaluation of interactive effects of UV light and nano encapsulation on the toxicity of azoxystrobin on zebrafish. Nanotoxicology. 2019; 14 (2):232-249.
Chicago/Turabian StyleYueyang Zhang; Claudia Sheedy; Denise Nilsson; Greg G. Goss. 2019. "Evaluation of interactive effects of UV light and nano encapsulation on the toxicity of azoxystrobin on zebrafish." Nanotoxicology 14, no. 2: 232-249.
Correction for ‘Toxicity of nanoencapsulated bifenthrin to rainbow trout (Oncorhynchus mykiss)’ by Tamzin A. Blewett et al., Environ. Sci.: Nano, 2019, 6, 2777–2785, DOI: 10.1039/C9EN00598F.
Tamzin A. Blewett; Arthur A. Qi; Yueyang Zhang; Alyssa M. Weinrauch; Salvatore D. Blair; Erik J. Folkerts; Claudia Sheedy; Denise Nilsson; Greg G. Goss. Correction: Toxicity of nanoencapsulated bifenthrin to rainbow trout (Oncorhynchus mykiss). Environmental Science: Nano 2019, 6, 3171 -3171.
AMA StyleTamzin A. Blewett, Arthur A. Qi, Yueyang Zhang, Alyssa M. Weinrauch, Salvatore D. Blair, Erik J. Folkerts, Claudia Sheedy, Denise Nilsson, Greg G. Goss. Correction: Toxicity of nanoencapsulated bifenthrin to rainbow trout (Oncorhynchus mykiss). Environmental Science: Nano. 2019; 6 (10):3171-3171.
Chicago/Turabian StyleTamzin A. Blewett; Arthur A. Qi; Yueyang Zhang; Alyssa M. Weinrauch; Salvatore D. Blair; Erik J. Folkerts; Claudia Sheedy; Denise Nilsson; Greg G. Goss. 2019. "Correction: Toxicity of nanoencapsulated bifenthrin to rainbow trout (Oncorhynchus mykiss)." Environmental Science: Nano 6, no. 10: 3171-3171.
Bifenthrin is an effective pyrethroid pesticide with known detrimental effects on aquatic biota, despite its relative insolubility in water.
Tamzin A. Blewett; Arthur A. Qi; Yueyang Zhang; Alyssa M. Weinrauch; Salvatore D. Blair; Erik J. Folkerts; Claudia Sheedy; Denise Nilsson; Greg G. Goss. Toxicity of nanoencapsulated bifenthrin to rainbow trout (Oncorhynchus mykiss). Environmental Science: Nano 2019, 6, 2777 -2785.
AMA StyleTamzin A. Blewett, Arthur A. Qi, Yueyang Zhang, Alyssa M. Weinrauch, Salvatore D. Blair, Erik J. Folkerts, Claudia Sheedy, Denise Nilsson, Greg G. Goss. Toxicity of nanoencapsulated bifenthrin to rainbow trout (Oncorhynchus mykiss). Environmental Science: Nano. 2019; 6 (9):2777-2785.
Chicago/Turabian StyleTamzin A. Blewett; Arthur A. Qi; Yueyang Zhang; Alyssa M. Weinrauch; Salvatore D. Blair; Erik J. Folkerts; Claudia Sheedy; Denise Nilsson; Greg G. Goss. 2019. "Toxicity of nanoencapsulated bifenthrin to rainbow trout (Oncorhynchus mykiss)." Environmental Science: Nano 6, no. 9: 2777-2785.
Copper nanoparticles and copper ions exert a different time-dependent toxicity pattern in rainbow trout olfactory system.
Parastoo Razmara; Ebrahim Lari; Effat Mohaddes; Yueyang Zhang; Greg G. Goss; Greg G. Pyle. The effect of copper nanoparticles on olfaction in rainbow trout (Oncorhynchus mykiss). Environmental Science: Nano 2019, 6, 2094 -2104.
AMA StyleParastoo Razmara, Ebrahim Lari, Effat Mohaddes, Yueyang Zhang, Greg G. Goss, Greg G. Pyle. The effect of copper nanoparticles on olfaction in rainbow trout (Oncorhynchus mykiss). Environmental Science: Nano. 2019; 6 (7):2094-2104.
Chicago/Turabian StyleParastoo Razmara; Ebrahim Lari; Effat Mohaddes; Yueyang Zhang; Greg G. Goss; Greg G. Pyle. 2019. "The effect of copper nanoparticles on olfaction in rainbow trout (Oncorhynchus mykiss)." Environmental Science: Nano 6, no. 7: 2094-2104.