Soil salinity and sodicity are twin constraints to agriculture production in many countries causing significant losses of crop production and land degradation. Once the salinity and sodicity problems are properly diagnosed, an integrated soil reclamation program may be formulated including combination of physical, chemical, hydrological and biological methods to rectify the twin problems. A combination of adaptation and mitigation technologies are to be adopted, for example adaptation allows the continued use of salt-affected soils by adjusting in response to the degree by which salinity and sodicity development has affected the soil, whereas, in contrast, mitigation refers to the technologies which are adopted to stop salinization to occur. It should be remembered that there is no single universal mitigation technology suitable for all soils, however, diagnostic based recommendations work satisfactorily for a specific site or location. Prior to setting up soil reclamation plan it is essential to review the available resources (farmer budget, availability and quality of water) and the objectives of reclamation and the reclamation plan established suiting the specific farmer needs. In this chapter, various soil reclamation methods such as; physical-leveling, subsoiling, mixing sand, seed bed preparation and salts scrapping); chemical (use of gypsum based on gypsum requirement, sulfur, acids etc.), hydrological-selection of suitable irrigation system-drip, sprinkler, bubbler, furrow, using the concept of leaching requiring/fraction to manage rootzone salinity, flushing, drainage, blending of water etc.; biological (use of organic amendments, green manuring, farm yard manures and selection of salt-tolerant crops) have be described. In addition, various methods of screening crops against salinity including hydroponics, field screening and serial biological concentration approach are described. Climate Smart Agriculture practices, integrated soil fertility management using 4 R nutrient stewardship are concisely reported. Procedures of salt-harvesting from saline lands and deep deposits and their commercial exploitation in industries are also introduced.