The low melting point of bismuth allows the fabrication of a lanthanide-doped Bi₂SiO₅ crystalline-core/glassy silica-shell system through a simple impregnation of MSNs followed by thermal treatment. The synthetic strategy could be used for the synthesis of a wide variety of bismuth-based nanosystems.

Background: TiO₂ nanoparticles (TiO₂ NPs) are the nanomaterial most produced as an ultraviolet (UV) filter. However, TiO₂ is a semiconductor and, in nanoparticle size, is a strong photocatalyst, raising concerns about photomutagenesis. Mesoporous silica nanoparticles (MSN) were synthetized incorporating TiO₂ NPs (TiO₂@MSN) to develop a cosmetic UV filter. The aim of this study was to assess the toxicity of TiO₂@MSN, compared with bare MSN and commercial TiO₂ NPs, based on several biomarkers. Materials and Methods: Human peripheral blood mononuclear cells (PBMC) were exposed to TiO₂@MSN, bare MSN (network) or commercial TiO₂ NPs for comparison. Exposed PBMC were characterized for cell viability/apoptosis, reactive oxygen species (ROS), nuclear morphology, and cytokines secretion. Results: All the nanoparticles induced apoptosis, but only TiO₂ NPs (alone or assembled into MSN) led to ROS and micronuclei. However, TiO₂@MSN showed lower ROS and cytotoxicity with respect to the P25. Exposure to TiO₂@MSN induced Th2-skewed and pro-fibrotic responses. Conclusions: Geno-cytotoxicity data indicate that TiO₂@MSN are safer than P25 and MSN. Cytokine responses induced by TiO₂@MSN are imputable to both the TiO₂ NPs and MSN, and, therefore, considered of low immunotoxicological relevance. This analytical assessment might provide hints for NPs modification and deep purification to reduce the risk of health effects in the settings of their large-scale manufacturing and everyday usage by consumers.

Cultural heritage assets face significant threats from climate change and land subsidence, leading to extensive social, economic, and environmental losses, and damage to artistic and monumental heritage in Italian coastal cities. In particular, addressing these challenges in the Venetian context necessitates the development of an adaptation plan for the lagoon area and the identification of targeted intervention strategies to preserve cultural and territorial heritage. To address these objectives, a systematic study was conducted to investigate the deterioration patterns exhibited by the most representative lithologies used in Venetian buildings. Thirty samples of five carbonate stone varieties subjected to natural aging were monitored in six different areas of Venice’s historic center and on Torcello Island, selected based on altimetry relative to tidal zero and exposure to environmental forces. An integrated multi-analytical approach was employed to identify and map macro- and micro-morphologies of stone surfaces related to chemical weathering and physical decay. Stones underwent evaluation during nine monitoring periods using various tests (ultrasound P-wave velocity and colorimetric measures) and analyses (µX-Ray Fluorescence, X-ray powder diffraction, stereomicroscope observations, and recognition of biological patinas). Data processing aimed to elucidate how microclimate and intrinsic stone features influence the occurrence and progression of deterioration phenomena. From the experimental findings, a Stone Deterioration Index and Intervention Procedures (SDIi) were proposed to estimate deterioration rates and assess the need for targeted intervention through conservative actions.