Rosalia Pellitteri

Dr. Rosalia Pellitteri

Institute for Biomedical Research and Innovation (IRIB), National Research Council
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Biography

Scientific activity: research in neurobiology and neuroanatomy. 1) Functional neuroanatomy of direct and collateralized axonal projections within the CNS with administration of retrograde fluorescent substances, such as Fluoro Gold, Fast Blue, Dil; 2) Immunohisto and -cytochemical techniques; 3) Behavioral analysis; 4) Effect of trophic or growth factors on development and survival of CNS neurons in vitro; 5) Interaction between neurons and glial cells (Schwann cell and Olfactory Ensheathing cells); 6) Fluorescence and Confocal Microscopy. At the present she conducts the following lines of ongoing research: 1) Phenotypic characterization and protective effects of olfactory glial cells, Olfactory Ensheathing Cells (OECs); 2) Protective effect of phyto-molecules on olfactory glial cells (OECs) cultured in vitro exposed to cytotoxicity by beta-amyloid fragments; 3) Cyto-compatibility of polymer nano-particles and their uptake at the cellular level, for the intranasal transport of drugs used for the treatment of CNS pathologies (epilepsy). 4) Biocompatibility between silicon supports and stem cells (dental pulp cells and OECs) as a possible regenerative model in damaged areas of the Nervous System. 5) Differentiation of stem cells derived from human adipose tissue stimulated by conditioned media from glial cells (OECs and Schwann cells) towards neural phenotypes.

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