Abhirup Das

Dr. Abhirup Das

University of New South Wales (UNSW) Australiadisabled, Sydney, Australia
orcid

Research Focus & Metrics

Academic Career Length

20Years (2007-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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12 January 2023 in Cell
Verified
Journal Article
Closed access
JYJae-Hyun Yang
Jae-Hyun Yang
MHMotoshi Hayano
Motoshi Hayano
PGPatrick T. Griffin
Patrick T. Griffin
JAJoão A. Amorim
João A. Amorim
MBMichael S. Bonkowski
Michael S. Bonkowski
DSDavid A. Sinclair
David A. Sinclair

1 March 2018 in Cell
Verified
Journal Article
Closed access
Abhirup DasAbhirup Das
Abhirup Das
GHGeorge X. Huang
George X. Huang
MBMichael S. Bonkowski
Michael S. Bonkowski
ALAlban Longchamp
Alban Longchamp
CLCatherine Li
Catherine Li
DSDavid A. Sinclair
David A. Sinclair

1 March 2018 in Cell
Verified
Journal Article
Closed access
ALAlban Longchamp
Alban Longchamp
TMTeodelinda Mirabella
Teodelinda Mirabella
AAAlessandro Arduini
Alessandro Arduini
MMMichael R. MacArthur
Michael R. MacArthur
Abhirup DasAbhirup Das
Abhirup Das
JMJames R. Mitchell
James R. Mitchell

1 December 2011 in Cell
Verified
Journal Article
Closed access
SLSergiy Libert
Sergiy Libert
KPKelli Pointer
Kelli Pointer
EBEric L. Bell
Eric L. Bell
Abhirup DasAbhirup Das
Abhirup Das
DCDena E. Cohen
Dena E. Cohen
LGLeonard Guarente
Leonard Guarente

17 March 2009 in Accounts of Chemical Research
Verified
Journal Article
Closed access
Abhirup DasAbhirup Das
Abhirup Das
CKChaitan Khosla
Chaitan Khosla

21 August 2018 in Nature Communications
Verified
Journal Article
Open access
PDF file
NTNigel Turner
Nigel Turner
XLXin Ying Lim
Xin Ying Lim
HTHamish D. Toop
Hamish D. Toop
BOBrenna Osborne
Brenna Osborne
ABAmanda E. Brandon
Amanda E. Brandon
Anthony DonAnthony Don
Anthony Don
Specific forms of the lipid ceramide, synthesized by the ceramide synthase enzyme family, are believed to regulate metabolic physiology. Genetic mouse models have established C16 ceramide as a driver of insulin resistance in liver and adipose tissue. C18 ceramide, synthesized by ceramide synthase 1 (CerS1), is abundant in skeletal muscle and suggested to promote insulin resistance in humans. We herein describe the first isoform-specific ceramide synthase inhibitor, P053, which inhibits CerS1 with nanomolar potency. Lipidomic profiling shows that P053 is highly selective for CerS1. Daily P053 administration to mice fed a high-fat diet (HFD) increases fatty acid oxidation in skeletal muscle and impedes increases in muscle triglycerides and adiposity, but does not protect against HFD-induced insulin resistance. Our inhibitor therefore allowed us to define a role for CerS1 as an endogenous inhibitor of mitochondrial fatty acid oxidation in muscle and regulator of whole-body adiposity.