Maret G. Traber’s research focuses on the importance and function of vitamin E in human health. She has evaluated “how much vitamin E do you need?” by developing methodologies for evaluating vitamin E status in humans using stable isotopes and identified key mechanisms for the regulation of vitamin E bioavailability in humans. Her team has identified key mechanisms in humans involved in the regulation of vitamin E discrimination, transport and use. Her team in collaboration with clinicians at the NIH have published in the AJCN clinical studies using deuterated tocopherols to quantitate vitamin E absorption and have used targeted metabolomics to evaluate excretion of vitamin E and its long chain catabolites in feces. These studies employed the use of defined diets, controlled eating patterns, complete urine and fecal sample collections. Additionally, to study vitamin E requirements during embryogenesis, she has used a zebrafish embryo model. Her team has also identified metabolic and molecular pathways that are dysregulated during vitamin E deficiency. Most recently her team has shown that vitamin E is critical for forming the brain during neurogenesis using this embryo model.