Yujiro Matsuishi is engaged in the fundamental study using rodents model and clinical study. Method and techniques for fundamental study: ・lipopolysaccharide-induced inflammation model in rodents. ・evaluate cytokines by ELIZA, RT-PCR, staining. Method and techniques for clinical study: ・Construct project ・Translation and validation study Statistics ・GLMM including Markov chain Monte Carlo methods(MCMC), Bayesian method. ・Propensity score matting method ・Mediation model statistics.