Our research is aimed at understanding the regulatory information and molecular mechanisms that control the patterning of the basic vertebrate body plan. We focus on head development and Hox genes as model systems to understand patterning mechanisms and regulatory networks in hindbrain segmentation and craniofacial development. Hox genes play critical roles in regulating regional diversity in many tissues. Hence, our goal has been to dissect the regulatory cascades that govern Hox expression and function in the head and CNS, and to build a basis for comparing and contrasting the Hox-dependent regulatory pathways that pattern diverse elements of the vertebrate body plan in development, disease, and evolution.
2018 Edwin G. Conklin Medal
Society for Developmental Biology
Recognition for outstanding achievements in scientific research and mentoring
Member National Academy of Sciences 2016
US National Academy of Sciences
Recognition for discoveries on Hox homeobox genes, which control the layout of a developing embryo. Uncovering the molecular and cellular pathways that govern the patterning of the nervous system, the establishment of the basic body plan, and craniofacial development of vertebrate embryos, particularly how these processes are altered or affected in human diseases.
President of Society for Developmental Biology 2105-2017
Society for Developmental Biology
Leading the efforts of the Society for Developmental Biology to promote its mission and enhance education, training and career development for the field.
Senior Scientist or Principal Investigator
Stowers Institute for Medical Research
01 Jul 2019 - present
Institute, Department or Faculty Head
Stowers Institute for Medical Research
01 Nov 2000 - 01 Jun 2019
Institute, Department or Faculty Head
MRC National Institute for Medical Research UK
01 Feb 1992 - 01 Oct 2000
Senior Scientist or Principal Investigator
National Institute for Medical Research UK
01 Sep 1985 - 01 Jan 1992
Post Doctoral Researcher
Fox Chase Cancer Institute
01 Mar 1982 - 01 Aug 1985
Post Doctoral Researcher
Beatson Institute for Cancer Research Glasgow Scotland
01 Sep 1979 - 01 Feb 1982
Graduate Student or Post Graduate
Ohio State University
01 Aug 1975 - 01 Mar 1979
Undergraduate Student
Vanderbilt University School of Engineering
01 Sep 1966 - 01 May 1970