We report a 10-month-old girl withKCNT1(c1420C > T; p. Arg474Cys, R474C) mutation-associated epileptic encephalopathy, systemic-to-pulmonary artery “collateralopathy”, and intermittent QTc prolongation. Spontaneous regression of systemic-to-pulmonary artery collateral-mediated left heart dilation was noted in this patient, a finding which was ominous as it heralded the onset of severe pulmonary hypertension. The structural and electrical phenotypic features ofKCNT1mutation-associated heart disease, including the novel findings noted in our patient, are discussed in detail.

In contrast to adults, severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) usually leads to a mild illness in children. However, a few children have been reported to have severe manifestations including pneumonia, acute kidney injury, multi-organ failure and cardiac injury. This review focuses on cardiac involvement during SARS-CoV-2 infection and the recently described likely immune mediated post-COVID-19 syndrome. Therapeutic strategies for cardiac dysfunction in both these settings are briefly discussed.