The aim was to investigate the influence of a carbohydrate (CHO) mouth rinse on the vastus lateralis (VL) and rectus femoris (RF) electromyographic activity (EMG) and time to exhaustion (TE) during moderate (MIE) and high-intensity cycling exercise (HIE). Thirteen participants cycled at 80% of their respiratory compensation point and at 110% of their peak power output to the point of exhaustion. Before the trials and every 15 min during MIE, participants rinsed with the CHO or Placebo (PLA) solutions. The root mean square was calculated. CHO had no effect on the TE during HIE (CHO: 177.3 ± 42.2 s; PLA: 163.0 ± 26.7 s, p = 0.10), but the TE was increased during MIE (CHO: 76.6 ± 19.7 min; PLA: 65.4 ± 15.2 min; p = 0.01). The EMG activity in the VL was higher than PLA at 30 min (CHO: 10.5% ± 2.6%; PLA: 7.7% ± 3.3%; p = 0.01) and before exhaustion (CHO: 10.3% ± 2.5%; PLA: 8.0% ± 2.9%; p = 0.01) with CHO rinsing. There was no CHO effect on the EMG activity of RF during MIE or for VL and RF during HIE. CHO mouth rinse maintains EMG activity and enhances performance for MIE but not for HIE.

Bastos-Silva, VJ, Prestes, J, and Geraldes, AAR. Effect of carbohydrate mouth rinse on training load volume in resistance exercises. J Strength Cond Res 33(6): 1654–1658, 2019—The aim of this study was to investigate the effect of carbohydrate (CHO) mouth rinse on training load volume (TLV—number of repetitions × load lifted [kg]) on 2 resistance exercises: leg press (LP) and bench press (BP). Twelve recreational resistance trained males were recruited. Subjects were assessed for 1 repetition maximum (1RM) and muscular endurance (ME) in LP and BP. Muscular endurance was determined by the maximum number of repetitions performed to volitional fatigue, with a load equal to 80% of 1RM. Exercises were performed on separate days (72 hours apart) under 3 experimental conditions: control (CONT), CHO (25 ml with 6.4% of maltodextrin), and placebo (juice without CHO [PLA]). Carbohydrate and PLA were used immediately before each exercise. There was no significant difference between conditions for the number of repetitions (CHO = 13.5 ± 4.8; PLA = 11.5 ± 4.4; CONT = 12.4 ± 4.4, p = 0.68) nor TLV (CHO = 2006.7 ± 825.2 kg; PLA = 1712.5 ± 772.9 kg; CONT = 1817.1 ± 672.6 kg, p = 0.99) in LP. However, CHO increased both repetitions (CHO = 8.2 ± 1.6; PLA = 7.1 ± 2.4; CONT = 6.8 ± 1.8, p = 0.002) and TLV (CHO = 557.1 ± 155.4 kg; PLA = 495.9 ± 206.1 kg; CONT = 476.1 ± 175.3 kg, p = 0.035) compared with CON in BP. Thus, a CHO mouth rinse increases BP performance in trained men, suggesting an interesting strategy to be used by experienced resistance training practitioners.

Article: Acute metformin intake on exercise performance in healthy participants during functional fitness training - The Journal of Sports Medicine and Physical Fitness 2024 Dec 09 - Minerva Medica - Journals

Introduction: Metformin is a widely prescribed drug for managing diabetes mellitus. Recent research has investigated its potential impact on cognitive function among individuals aged 60 years and older—a population that is steadily increasing and often exhibits cognitive impairments associated with aging and diabetes mellitus. Objective: This study aimed to evaluate the impact of metformin use on cognitive functions in older adults with diabetes mellitus through a meta-analysis. Methods: A systematic review and meta-analysis were conducted in accordance with PRISMA guidelines, utilizing the Embase, LILACS, PubMed, Scopus, and Web of Science databases. The review protocol was registered in PROSPERO (CRD42024624045). Results: Thirteen articles met the eligibility criteria for inclusion in this systematic review, of which five provided sufficient data for meta-analysis. The findings indicate that metformin has a small but positive effect on overall cognitive function in older adults. Additionally, the meta-analysis demonstrated low heterogeneity (49.6%) and a low risk of bias (p > 0.05). Conclusion: The results suggest that metformin not only improves glycemic levels, but may also have a protective effect on the overall cognitive function of older people with diabetes mellitus.