The contemporary academic literature starts to recognize the importance of an individual in an organization, region, and national economy performance. Scholars try to explore the essence of interconnection between various forms of capital, institutional environment, and values. Hence, this article’s relevance is determined by the need to study the mechanisms of human capital and socio-economic achievements interrelation. Human capital originates from knowledge, skills, abilities, and others characteristics of a person. It is not limited by a single individual, since, on the unit level, it becomes a resource through association and complementarity. The obtained combinations of human capital are complex, and almost all of them are specific to a particular organization. Therefore, the authors argue that competitive advantage is achieved mainly through a unique combination of human capital resources. This article presents the key conceptual provisions of the polyparadigm research program of human capital phenomenon. The novelty of the article is determined, firstly, by a detailed description of human capital components, and secondly, by a proposal to implement the idea of interdisciplinary research. The authors have developed and tested a methodology that will allow for a comprehensive modular measurement of human capital, as well as for modeling and evaluating its impact on economic performance of micro-, meso-, and macro-entities in the context of economy digitalization. The analysis base includes philosophical approaches, system analysis, social theories, sociology (including mathematical sociology), psychology, and economics. Systematization and typologization of scientific sources makes it possible to form a wide range of models of multilevel human capital and its resources. Moreover, the authors propose to initiate an interdisciplinary discussion, aimed at increasing the openness and productivity of research in this field.