Volatile organic compounds (VOCs) are contained in various construction materials and interior equipment. Their higher concentrations in the indoor air are associated with negative effects on human health and are disputed in terms of health risk, since people spend a considerable part of their lifetime indoors. Therefore, the presence of VOCs in indoor air is a case of concern regarding sick building syndrome (SBS). From a historical point of view, wood and wood-based panels represent a widely used material. Nevertheless, wood appears to be nowadays a product and a material of a sustainable future. Depending on wood extractives’ composition and an abundance of diverse wood species, different profiles of volatiles are emitted. In case of wood-based panels, the impact of adhesives and additives that are essentially applied aiming to adjust the panels’ properties is even enriching this cocktail of chemicals. This paper comprises the issue of VOCs emitted from wood and wood-based panels. The most abundant VOCs were summarized. The options of VOCs for analytical determination from these matrixes are described with their benefits and limitations.