Christos Yapijakis

Prof. Dr. Christos Yapijakis

orcid

Research Focus & Metrics

Academic Career Length

38Years (1989-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 May 2006 in International Journal of Infectious Diseases
Verified
Journal Article
Closed access
MPManolis J. Papagrigorakis
Manolis J. Papagrigorakis
CYChristos Yapijakis
Christos Yapijakis
PSPhilippos N. Synodinos
Philippos N. Synodinos
EBEffie Baziotopoulou-Valavani
Effie Baziotopoulou-Valavani

1 April 2008 in Oral Oncology
Verified
Journal Article
Closed access
EVE. Vairaktaris
E. Vairaktaris
SSS. Spyridonidou
S. Spyridonidou
VPV. Papakosta
V. Papakosta
AVA. Vylliotis
A. Vylliotis
ALA. Lazaris
A. Lazaris
EPE. Patsouris
E. Patsouris

1 March 2002 in European Journal of Human Genetics
Verified
Journal Article
Closed access
PDF file
GEGerry Evers-Kiebooms
Gerry Evers-Kiebooms
KNKurt Nys
Kurt Nys
PHPeter Harper
Peter Harper
MZMoniek Zoeteweij
Moniek Zoeteweij
ADAlexandra Dürr
Alexandra Dürr
SSSheila Simpson
Sheila Simpson

1 October 1989 in Journal of Molecular Biology
Verified
Journal Article
Closed access
KTKathleen Triman
Kathleen Triman
EBElisa Becker
Elisa Becker
CDCarol Dammel
Carol Dammel
JKJohn Katz
John Katz
HMHiro Mori
Hiro Mori
HNHarry F. Noller
Harry F. Noller

27 August 2002 in Neurology
Verified
Journal Article
Closed access
PDF file
GBG. J. Breedveld
G. J. Breedveld
APA. K. Percy
A. K. Percy
MMM. E. MacDonald
M. E. MacDonald
BVB. B.A. de Vries
B. B.A. de Vries
CYChristos Yapijakis
Christos Yapijakis
WAW. F.M. Arts
W. F.M. Arts
Background: Benign hereditary chorea (BHC) is an autosomal dominant disorder that can be distinguished from Huntington disease by its early onset, stable or only slightly progressive course, and absence of mental deterioration. The variation in clinical features is such that its very existence has been doubted. The authors recently described the localization of a gene responsible for BHC on chromosome 14q in a large Dutch family. Objective: To report results of extensive clinical and linkage analyses for this Dutch family and six other families with BHC. Results: Three of the seven families had linkage to a region on chromosome 14q13.1-q21.1. HOMOG analysis showed odds of 10 × 1011 in favor of locus heterogeneity. Haplotype analyses for the linked families resulted in a reduction of the critical interval for the BHC gene to 8.4 cM between marker D14S49 and marker D14S278. Clinically, these three families had a homogeneous picture with early-onset chorea, sometimes accompanied by slight ataxia in walking, but without dystonia, myoclonic jerks, or dysarthria. The severity of the choreatic movements tended to abate in adolescence or early adulthood. In the unlinked families, symptoms and signs were more heterogeneous as to age at onset and the occurrence of myoclonic jerks or dystonia. Conclusions: BHC is a clinically and genetically heterogeneous disorder, with one well-defined clinical syndrome mapping to chromosome 14q.

28 May 2002 in International Journal of Andrology
Verified
Journal Article
Open access
PDF file
AKA. Kukuvitis
A. Kukuvitis
IGI. Georgiou
I. Georgiou
IBI. Bouba
I. Bouba
ATA. Tsirka
A. Tsirka
CGCh. Giannouli
Ch. Giannouli
JPJ. Papadimas
J. Papadimas
This study was performed to examine the contribution of genetic polymorphism of oestrogen and androgen receptor (AR) genes in male infertility. We have studied in total 173 Greek men, 109 infertile patients and 64 controls (group A). Patients were divided in to three subgroups: group B (n=29) with idiopathic moderate oligospermia, group C (n=42) with azoospermia or idiopathic severe oligospermia and group D (n=38) with azoospermia or oligospermia of various known aetiologies. All patients and controls were genotyped for two polymorphisms of the oestrogen receptor α (ERα) gene and also for the (CAG)n repeat length polymorphism of the X‐linked androgen receptor (AR)gene. The control group had statistically significant difference from group C regarding the XbaI polymorphism of ERα gene. Despite the fact that we did not observe any statistically significant differences in the mean and range of the CAG repeat number, the frequency of the higher repeats of the nucleotide repeat sequence (CAG)n of the AR gene was 2–4 times higher in groups B and C compared with the control group A. Our results indicate that both ERα and AR gene play significant role in male fertility. It is possible that a synergy may exist between unfavourable genotypes of these two genes in male infertility.