Geothermal energy potential is identified through the deep investigation of geological, geothermal, and geophysical information over a small area; however, this task is both expensive and complex. Geographic Information Systems (GIS) can integrate different types of data (or thematic layers) over large regions and use them to identify zones of high geothermal potential. In this study, we use GIS as a tool to construct the first regional-scale geothermal potential map of Africa from different datasets. The key objective of this study is to estimate the geothermally promising areas within Africa by integrating geological thematic layers (rock units and faults), geophysical layers (heat flow derived from aeromagnetic data and seismicity), and geothermal layers (hot springs and volcanoes) within the GIS database. A weighted overlay technique within the GIS environment is applied to these data to generate the geothermal potential map. The result shows 14 regions with a high geothermal favorability index. The geothermal potential map of Africa is useful for targeting and exploring new geothermal renewable energy sites and can reduce exploration costs and pinpoint investigation areas during preliminary geothermal studies.