During the last few years, the preparation of novel fluorescent probes for the selective detection of chemical species inside mitochondria has attracted considerable attention because of their wide applications in chemistry, biology, and medical science. This feature article focuses on the recent advances in the design principles and recognition mechanisms of these kinds of fluorescent probes. In addition, their applications for the detection of reactive oxygen species (ROS), nitric oxide, reactive sulfur species (RSS), thioredoxin (Trx), metal ions, anions, etc. in the mitochondrion is discussed as well.

During the past few years, the construction of BODIPY-based macrocycles has attracted extensive interest due to the widespread applications of these materials in sensing, bioimaging, molecular machines, and photodynamic therapy (PDT). Since significant progress has been made in this field, it is time to summarize the recent developments involving BODIPY-based macrocycles. In this review, we will briefly introduce the synthesis routes of BODIPY-based macrocycles, including a covalent synthetic protocol and a noncovalent self-assembly protocol. In addition, we will discuss the photophysical and photochemical properties and the applications of these BODIPY-based macrocycles in the areas of sensing, bioimaging, photodynamic therapy, etc.

Two-dimensional metallacycles and three-dimensional metallacages constructed by coordination-driven self-assembly have attracted much attention because they exhibit unique structures and properties and are highly efficient to synthesize. Introduction of switching into supramolecular chemistry systems is a popular strategy, as switching can endow systems with reversible features that are triggered by different stimuli. Through this strategy, novel switchable metallacycles and metallacages were generated, which can be reversibly switched into different stable states with distinct characteristics by external stimuli. Switchable metallacycles and metallacages exhibit versatile structures and reversible properties and are inherently dynamic and respond to artificial signals; thus, these structures have many promising applications in a wide range of fields, such as drug delivery, data processing, pollutant removal, switchable catalysis, smart functional materials, etc. This review focuses on the design of switchable metallacycles and metallacages, their switching behaviours and mechanisms triggered by external stimuli, and the corresponding structural changes and resultant properties and functions.

In the past few years, the preparation of novel small-molecule fluorescent probes for specific detection and imaging of chemical species inside lysosomes has attracted considerable attention because of their wide applications in chemistry, biology, and medical science. This feature article summarizes the recent advances in the design and preparation of small-molecule fluorescent probes for specific detection of chemical species inside lysosomes. In addition, their properties and applications for the detection and imaging of pH, H₂O₂, HOCl, O₂˙⁻, lipid peroxidation, H₂S, HSO₃ ⁻, thiols, NO, ONOO⁻, HNO, Zn²⁺, Cu²⁺, enzymes, etc. in lysosomes are discussed as well.