To describe both the global and local characteristics of a network more comprehensively, we propose the weighted K-order propagation number (WKPN) algorithm to extract the disease propagation based on the network topology to evaluate the node importance. Each node is set as the source of infection, and the total number of infected nodes is defined as the K-order propagation number after experiencing the propagation time K. The simulation of the symmetric network with bridge nodes indicated that the WKPN algorithm was more effective for evaluation of the algorithm features. A deliberate attack strategy, which indicated an attack on the network according to the node importance from high to low, was employed to evaluate the WKPN algorithm in real networks. Compared with the other methods tested, the results demonstrate the applicability and advancement that a lower number of nodes, with a higher importance calculated by the K-order propagation number algorithm, has to achieve full damage to the network structure.