Authors’ Contributions Yen-Kuang Lin, Chi-Tai Yeh: data acquisition and collation, manuscript writing; Vijesh Kumar Yadav: data collation and manuscript writing; Kuang-Tai Kuo and Iat-Hang Fong: study conception, experimental design, data collation and interpretation, bioinformatics, and manuscript writing; Kuang-Tai Kuo: critical review of initial draft; Nicholas G. Kounis and Patrick Hu: experimental design, critical review of initial draft, and provision of research materials; Ming-Yow Hung: study conception, experimental design, data collation, manuscript writing and provision of research materials. All authors read and approved the submitted version of the manuscript.