The development of innovative approaches that would reduce the sensitivity of healthy tissues to irradiation while maintaining the efficacy of the treatment on the tumor is of crucial importance for the progress of the efficacy of radiotherapy. Recent methodological developments and innovations, such as scanned beams, ultra-high dose rates, and very high-energy electrons, which may be simultaneously available on new accelerators, would allow for possible radiobiological advantages of very short pulses of ultra-high dose rate (FLASH) therapy for radiation therapy to be considered. In particular, very high-energy electron (VHEE) radiotherapy, in the energy range of 100 to 250 MeV, first proposed in the 2000s, would be particularly interesting both from a ballistic and biological point of view for the establishment of this new type of irradiation technique. In this review, we examine and summarize the current knowledge on VHEE radiotherapy and provide a synthesis of the studies that have been published on various experimental and simulation works. We will also consider the potential for VHEE therapy to be translated into clinical contexts.

We revisit the cosmological evolution of domain wall networks, taking advantage of recent improvements in computing power. We carry out high-resolution field theory simulations in two, three and four spatial dimensions to study the effects of dimensionality and damping on the evolution of the network. Our results are consistent with the expected scale-invariant evolution of the network, which suggests that previous hints of deviations from this behavior may have been due to the limited dynamical range of those simulations. We also use the results of very large (10243) simulations in three cosmological epochs to provide a calibration for the velocity-dependent one-scale model for domain walls: we numerically determine the two free model parameters to have the values cw=0.5\ifmmode\pm\else\textpm\fi{}0.2 and kw=1.1\ifmmode\pm\else\textpm\fi{}0.3.

We report on a detailed numerical study of the evolution of semilocal string networks, based on the largest and most accurate field theory simulations of these objects to date. We focus on the large-scale network properties, confirming earlier indications (coming from smaller simulations) that linear scaling is the attractor solution for the entire parameter space of initial conditions that we are able to probe. We also provide a brief comparison of our numerical results with the predictions of a previously developed one-scale model for the overall evolution of these networks. Two subsequent papers will discuss in more detail the analytic modeling of the semilocal segment populations as well as optimized numerical diagnostics.DOI: http://dx.doi.org/10.1103/PhysRevD.89.063503Published 5 March 2014Received 7 December 2013© 2014 American Physical Society

The ASACUSA collaboration at the Antiproton Decelerator of CERN aims at a precise measurement of the antihydrogen ground-state hyperfine structure as a test of the fundamental CPT symmetry. A beam of antihydrogen atoms is formed in a CUSP trap, undergoes Rabi-type spectroscopy and is detected downstream in a dedicated antihydrogen detector. In parallel measurements using a polarized hydrogen beam are being performed to commission the spectroscopy apparatus and to perform measurements of parameters of the Standard Model Extension (SME). The current status of antihydrogen spectroscopy is reviewed and progress of ASACUSA is presented.