Neurofibromatosis type 1 (NF1) is a complex autosomal dominant disorder associated with germline mutations in the NF1 tumor suppressor gene. NF1 belongs to a class of congenital anomaly syndromes called RASopathies, a group of rare genetic conditions caused by mutations in the Ras/mitogen-activated protein kinase pathway. Generally, NF1 patients present with dermatologic manifestations. In this review the main features of café-au-lait macules, freckling, neurofibromas, juvenile xanthogranuloma, nevus anemicus and other cutaneous findings will be discussed.

Citation: Ozarslan B, Russo T, Argenziano G, Piccolo V. Natalizumab-Induced Pustular Psoriasis of Palms and Soles. Dermatol Pract Concept. 2022;12(2):e2022088. DOI: https://doi.org/10.5826/dpc.1202a88 Accepted: September 18, 2021; Published: April 2022 Copyright: ©2022 Ozarslan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (BY-NC-4.0), https://creativecommons.org/licenses/by-nc/4.0/, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original authors and source are credited. Funding: None. Competing interests: None. Authorship: All authors have contributed significantly to this publication Corresponding author: Vincenzo Piccolo, MD, c/o II Policlinico, building 9, first floor, via Pansini 5 - 80131 Napoli, Italy. Email: piccolo.vincenzo@gmail.com Keywords : natalizumab, psoriasis, pustular, palmoplantar This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.