The major focus of my group is to understand the molecular mechanisms involved in genetic diseases and cancer development. We are using whole genomic analysis to identify and characterize genetic program/gene pathways that drive tumorigenic processes, and biomarkers of diagnosis, prognosis and therapeutic orientation. We are also interested in the characterization of biological properties of Cancer Stem Cells (CSCs), which present self-renewal capacity, unlimited proliferative potential, differentiation competence, and are extremely resistant to radio and chemotherapies. For this pourpose, we are applying next generation sequencing in order to profile gene expression, characterize epigenetic alterations, detect chromosomal rearrangements, and single nucleotide variations in coding and regulatory gene regions (RNA-seq, ChIP-seq, DNA methylation, Exome, and scRNA-seq protocols) in several solid tumors including: head and neck carcinoma, colorectal carcinoma, glioblastoma, Melanoma, and penile carcinoma.