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Dr. Mamoru Ayusawa
Department of Pediatrics and Child Health, Nihon University School of Medicine & Itabashi Hospital, Tokyo, Japan

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0 Pediatric Cardiology
0 ventricular arrhythmias
0 Kawasaki Disease
0 Sudden cardiac death (SCD)

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Kawasaki Disease
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Sudden cardiac death (SCD)

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Editorial
Published: 19 January 2021 in Frontiers in Pediatrics
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Editorial on the Research Topic Kawasaki Disease On June 5, 2020, the esteemed Dr. Tomisaku Kawasaki, the pediatrician who first described mucocutaneous lymph node syndrome (later named in his honor) passed away at the age of 95 (1). For 53 years from the time, he published the first 50 cases of this syndrome, he inspired and encouraged researchers around the world to study this elusive illness (2). Since many questions remain regarding Kawasaki disease (KD) in terms of epidemiology, pathology, immunology, cause, and cardiovascular injury, Frontiers in Pediatrics offered us a collection of articles related to KD as a Research Topic. This issue of 13 articles concerning KD in Frontiers in Pediatrics demonstrates the commitment from clinical researchers around the globe to better understand this elusive illness. This issue includes, for the first time, an explanation of the presentation and outcome of infants with KD and adjunctive therapies for children suffering from KD in a region of the world (Latin America) where little has been previously published about KD. Two comprehensive articles concerning infantile KD cases warn that patients younger than 3–6 months have a higher rate of coronary artery aneurysms. Garrido-Garcia et al., found that these very young infants were particularly at high risk for KD shock and giant coronary artery aneurysms. Moreno et al. found that the admission diagnosis of infants <6 months old ultimately diagnosed with KD was in error in more than 60% of these infants. Fortuna-Reyna et al. detailed for the first time additional therapies administered throughout Latin America for IVIG-resistant KD and aneurysms, revealing a limitation in adjunctive therapies in this part of the world. These works come from the Latin American KD Network (REKAMLATINA- Red de la Enfermedad de Kawasaki en America Latina) (3), inspired by dedicated Latin American physicians that have taken to heart Dr. Kawasaki's call to study this illness. A case report entitled by Saez-de-Ocariz et al. from Mexico highlighted that at times there is a complexity in differentiating KD from other vasculitides. The work presented also demonstrates a collaborative network of researchers from the US, Europe, and the UK addressing the complexity of the diagnosis of KD with biomarkers, as written in the article by Zandstra et al.. Ching et al. from the Hawaii University investigated a novel biomarker related to cardiovascular dysregulation, and reported the possibility of a novel factor predicting the complication of coronary artery. The risk of hemolysis due to high levels of IVIG therapy, especially in obese children, is addressed in the article by Van Anh et al., which sheds lights on the risk/benefit ratio of IVIG in the context of the obesity epidemic. Extensive body of work also illustrates the impact of research from Asian countries affected by KD, including Taiwan, China, and Japan. Ming-Huey Guo et al. is an original research article reporting a potentially novel mechanism of macrophage polarization control. The authors found alterations in markers that respond to CpG site methylation in patients with KD. Further, Liu et al. from China, showed swelling of extremities and polymorphous rash, as well as laboratory values, linked to IVIG-resistance. Okubo et al. is a multi-center study from Japan investigated differences in treatment selection and prognosis of the coronary artery outcomes before and after 2012 when the Japanese guidelines shifted toward the utilization of combined immuno-globulin and glucocorticoid therapy. Ito et al. examined the rate of coronary artery aneurysms and IVIG resistance in children administered 30 vs. 50 mg/kg/days during the acute phase of KD. Oshima et al. cautioned about the management of water and electrolytes in the acute phase of severe KD cases. Akimoto et al. discusses the complexities of surgically managing giant aneurysms. This international effort underscores the importance that we continue to work collectively to understand KD better and honor Dr. Kawasaki's work. We wish to inspire the whole medical community with Dr. Kawasaki's words, “Be Strict for the Medical Study, Be Warm for the Medical Practice.” MA reviewed the articles submitted from Asian countries and edited them, unless he disclosed a conflict of interest as a co-author. IM managed and advised the article collection comprehensively. AT reviewed the submitted articles from Europe and the Americas, and edited them, unless she disclosed a conflict of interest as a co-author. All authors contributed to the article and approved the submitted version. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. We thank Prof. Andrew Landstrom, Prof. Matthias Sigler, Prof. Ho-Chang Kuo, Prof. Ruth Heying, and Prof. Michael Portman for their editing work. They provided assistance where we had shared affiliations with the authors of the papers. 1. Green A. Obituary Tomisaku Kawasaki. Lancet. (2020) 396:71–142.e1 PubMed Abstract | Google Scholar 2. Kawasaki T. Pediatric acute febrile mucocutaneous lymph node syndrome: clinical observation of 50 cases. Jpn J Allergy. (1967) 16:178–222. Google Scholar 3. González-Mata A, Ulloa-Gutiérrez R, Brea J, Soza G, Tremoulet AH. Origin and importance of the Latin American Kawasaki Disease Network (REKAMLATINA). Rev Chilena Infectol. (2014) 31:330–2. doi: 10.4067/S0716-10182014000300012 PubMed Abstract | CrossRef Full Text | Google Scholar Keywords: Kawasaki disease, Tomisaku Kawasaki, vasculitis, infant, coronary artery aneurysm, infant, children Citation: Ayusawa M, Morioka I and Tremoulet A (2021) Editorial: Kawasaki Disease. Front. Pediatr. 8:631157. doi: 10.3389/fped.2020.631157 Received: 19 November 2020; Accepted: 17 December 2020; Published: 19 January 2021. Edited and reviewed by: Ruth Heying,...

ACS Style

Mamoru Ayusawa; Ichiro Morioka; Adriana Tremoulet. Editorial: Kawasaki Disease. Frontiers in Pediatrics 2021, 8, 1 .

AMA Style

Mamoru Ayusawa, Ichiro Morioka, Adriana Tremoulet. Editorial: Kawasaki Disease. Frontiers in Pediatrics. 2021; 8 ():1.

Chicago/Turabian Style

Mamoru Ayusawa; Ichiro Morioka; Adriana Tremoulet. 2021. "Editorial: Kawasaki Disease." Frontiers in Pediatrics 8, no. : 1.

Obituary
Published: 21 October 2020 in Pediatrics International
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Mamoru Ayusawa. Obituary for Dr Tomisaku Kawasaki (February 7, 1925–June 5, 2020). Pediatrics International 2020, 62, 1129 -1130.

AMA Style

Mamoru Ayusawa. Obituary for Dr Tomisaku Kawasaki (February 7, 1925–June 5, 2020). Pediatrics International. 2020; 62 (10):1129-1130.

Chicago/Turabian Style

Mamoru Ayusawa. 2020. "Obituary for Dr Tomisaku Kawasaki (February 7, 1925–June 5, 2020)." Pediatrics International 62, no. 10: 1129-1130.

Guidelines
Published: 01 October 2020 in Pediatrics International
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Tohru Kobayashi; Mamoru Ayusawa; Hiroyuki Suzuki; Jun Abe; Shuichi Ito; Taichi Kato; Masahiro Kamada; Junko Shiono; Kenji Suda; Keiji Tsuchiya; Tsuneyuki Nakamura; Yoshikazu Nakamura; Yuichi Nomura; Hiromichi Hamada; Ryuji Fukazawa; Kenji Furuno; Hiroyuki Matsuura; Tomoyo Matsubara; Masaru Miura; Kei Takahashi. Revision of diagnostic guidelines for Kawasaki disease (6th revised edition). Pediatrics International 2020, 62, 1135 -1138.

AMA Style

Tohru Kobayashi, Mamoru Ayusawa, Hiroyuki Suzuki, Jun Abe, Shuichi Ito, Taichi Kato, Masahiro Kamada, Junko Shiono, Kenji Suda, Keiji Tsuchiya, Tsuneyuki Nakamura, Yoshikazu Nakamura, Yuichi Nomura, Hiromichi Hamada, Ryuji Fukazawa, Kenji Furuno, Hiroyuki Matsuura, Tomoyo Matsubara, Masaru Miura, Kei Takahashi. Revision of diagnostic guidelines for Kawasaki disease (6th revised edition). Pediatrics International. 2020; 62 (10):1135-1138.

Chicago/Turabian Style

Tohru Kobayashi; Mamoru Ayusawa; Hiroyuki Suzuki; Jun Abe; Shuichi Ito; Taichi Kato; Masahiro Kamada; Junko Shiono; Kenji Suda; Keiji Tsuchiya; Tsuneyuki Nakamura; Yoshikazu Nakamura; Yuichi Nomura; Hiromichi Hamada; Ryuji Fukazawa; Kenji Furuno; Hiroyuki Matsuura; Tomoyo Matsubara; Masaru Miura; Kei Takahashi. 2020. "Revision of diagnostic guidelines for Kawasaki disease (6th revised edition)." Pediatrics International 62, no. 10: 1135-1138.

Case report
Published: 17 July 2020 in Frontiers in Pediatrics
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We report the case of a 3-years-old boy who developed severe hyponatremia and unconsciousness during an episode of Kawasaki disease (KD). He was diagnosed with cerebral salt-wasting syndrome (CSWS), which has not previously been reported as a complication of KD. He was diagnosed with KD with fever and four clinical signs and received intravenous immunoglobulin (IVIG) on the day after onset. Hyponatremia had been observed, and it worsened after IVIG. At first, syndrome of inappropriate antidiuretic hormone secretion (SIADH) was suspected, but his hyponatremia did not improve by restriction of water intake. The patient's consciousness level decreased along with the worsening hyponatremia. Electroencephalography revealed abnormal electrical discharge concordant with acute encephalopathy. Laboratory data showed hypouricemia with high fractional excretion of uric acid (FEUA), in addition to a negative balance of both Na and water. We diagnosed KD complicated with CSWS. The patient improved promptly with appropriate Na supplementation and water correction.

ACS Style

Masanari Oshima; Junji Fukuhara; Takanori Noto; Teppei Noguchi; Masao Murabayashi; Mamoru Ayusawa; Ichiro Morioka. A Case of Kawasaki Disease Complicated With Cerebral Salt-Wasting Syndrome. Frontiers in Pediatrics 2020, 8, 325 .

AMA Style

Masanari Oshima, Junji Fukuhara, Takanori Noto, Teppei Noguchi, Masao Murabayashi, Mamoru Ayusawa, Ichiro Morioka. A Case of Kawasaki Disease Complicated With Cerebral Salt-Wasting Syndrome. Frontiers in Pediatrics. 2020; 8 ():325.

Chicago/Turabian Style

Masanari Oshima; Junji Fukuhara; Takanori Noto; Teppei Noguchi; Masao Murabayashi; Mamoru Ayusawa; Ichiro Morioka. 2020. "A Case of Kawasaki Disease Complicated With Cerebral Salt-Wasting Syndrome." Frontiers in Pediatrics 8, no. : 325.

Journal article
Published: 03 April 2019 in Resuscitation
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Sudden cardiac death during exercise or sports is an important problem among young athletes and non-athletes. An understanding of the epidemiological features of sports-related out-of-hospital cardiac arrest (OHCA) among children is crucial for planning approaches for prevention and better outcomes of paediatric OHCAs. We assessed the characteristics and outcomes of sports-related OHCA among children at schools in Japan to prevent sports-related paediatric OHCA at schools. The Stop and Prevent cardIac aRrest, Injury, and Trauma in Schools (SPIRITS) is a nationwide, prospective, observational study linking databases of two nationally representative registries. Data on the characteristics and outcomes of sports-related paediatric OHCA at schools in Japan were obtained from these databases. Between 2008 and 2015, 188 sports-related paediatric OHCAs due to presumed cardiac origin occurred. The greatest proportion of OHCA during or after sports was due to long-distance running (21.8%), followed by soccer/futsal (13.3%), basketball (12.2%), and baseball/rubber-ball baseball (11.2%). We also assessed the association between prehospital factors and one-month survival with favourable neurological outcome after sports-related OHCA. The proportions of ventricular fibrillation as the first documented rhythm, bystander cardiopulmonary resuscitation (CPR), and public-access defibrillation (PAD) were 87.8%, 87.2%, and 63.3%, respectively. Compared with the non-PAD group, the adjusted odds ratio (95% confidence interval) of the PAD group was 3.64 (1.78–7.45). In Japan, 188 schoolchildren experienced OHCAs of cardiac origin occurring during or after sports activity at schools during the 8-year period. Increasing PAD is essential to enhance better neurological outcome after sports-related OHCA among students.

ACS Style

Junya Sado; Kosuke Kiyohara; Tetsuhisa Kitamura; Satoshi Matsui; Mamoru Ayusawa; Masahiko Nitta; Taku Iwami; Ken Nakata; Tomotaka Sobue; Yuri Kitamura. Sports activity and paediatric out-of-hospital cardiac arrest at schools in Japan. Resuscitation 2019, 139, 33 -40.

AMA Style

Junya Sado, Kosuke Kiyohara, Tetsuhisa Kitamura, Satoshi Matsui, Mamoru Ayusawa, Masahiko Nitta, Taku Iwami, Ken Nakata, Tomotaka Sobue, Yuri Kitamura. Sports activity and paediatric out-of-hospital cardiac arrest at schools in Japan. Resuscitation. 2019; 139 ():33-40.

Chicago/Turabian Style

Junya Sado; Kosuke Kiyohara; Tetsuhisa Kitamura; Satoshi Matsui; Mamoru Ayusawa; Masahiko Nitta; Taku Iwami; Ken Nakata; Tomotaka Sobue; Yuri Kitamura. 2019. "Sports activity and paediatric out-of-hospital cardiac arrest at schools in Japan." Resuscitation 139, no. : 33-40.

Clinical notes
Published: 21 October 2018 in Pediatrics International
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Yuriko Abe; Naokata Sumitomo; Mamoru Ayusawa; Tsutomu Yamada; Masahiko Sugitani. Congenital multiple pulmonary vein atresia and stenosis in an infant. Pediatrics International 2018, 60, 976 -978.

AMA Style

Yuriko Abe, Naokata Sumitomo, Mamoru Ayusawa, Tsutomu Yamada, Masahiko Sugitani. Congenital multiple pulmonary vein atresia and stenosis in an infant. Pediatrics International. 2018; 60 (10):976-978.

Chicago/Turabian Style

Yuriko Abe; Naokata Sumitomo; Mamoru Ayusawa; Tsutomu Yamada; Masahiko Sugitani. 2018. "Congenital multiple pulmonary vein atresia and stenosis in an infant." Pediatrics International 60, no. 10: 976-978.

Journal article
Published: 25 September 2018 in Circulation Journal
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Background: Left ventricular non-compaction (LVNC) is a cardiomyopathy morphologically characterized by 2-layered myocardium and numerous prominent trabeculations, and is often associated with dilated cardiomyopathy (DCM). Variants in the gene encoding tafazzin (TAZ) may change mitochondrial function and cause dysfunction of many organs, but they also contribute to the DCM phenotype in LVNC, and the clinical and echocardiographic features of children with this phenotype are poorly understood. Methods and Results: We enrolled 92 DCM phenotype LVNC patients and performed next-generation sequencing to identify the genetic etiology. Ten TAZ variants were identified in 15 male patients (16.3%) of the 92 patients, including 3 novel missense substitutions. The patients with TAZ variants had a higher frequency of early onset of disease (92.3% vs. 62.3%, P=0.0182), positive family history (73.3% vs. 20.8%, P=0.0001), and higher LV posterior wall thickness Z-score (8.55±2.60 vs. 5.81±2.56, P=0.0103) than those without TAZ variants, although the mortality of both groups was similar. Conclusions: This study provides new insight into the impact of DCM phenotype LVNC and emphasizes the clinical advantages available for LVNC patients with TAZ variants.

ACS Style

Keiichi Hirono; Yukiko Hata; Makoto Nakazawa; Nobuo Momoi; Tohru Tsuji; Taro Matsuoka; Mamoru Ayusawa; Yuriko Abe; Tamaki Hayashi; Nobuyuki Tsujii; Tadaaki Abe; Heima Sakaguchi; Ce Wang; Asami Takasaki; Shinya Takarada; Mako Okabe; Nariaki Miyao; Hideyuki Nakaoka; Keijiro Ibuki; Kazuyoshi Saito; Sayaka Ozawa; Naoki Nishida; Neil E. Bowles; Fukiko Ichida. Clinical and Echocardiographic Impact of Tafazzin Variants on Dilated Cardiomyopathy Phenotype in Left Ventricular Non-Compaction Patients in Early Infancy. Circulation Journal 2018, 82, 2609 -2618.

AMA Style

Keiichi Hirono, Yukiko Hata, Makoto Nakazawa, Nobuo Momoi, Tohru Tsuji, Taro Matsuoka, Mamoru Ayusawa, Yuriko Abe, Tamaki Hayashi, Nobuyuki Tsujii, Tadaaki Abe, Heima Sakaguchi, Ce Wang, Asami Takasaki, Shinya Takarada, Mako Okabe, Nariaki Miyao, Hideyuki Nakaoka, Keijiro Ibuki, Kazuyoshi Saito, Sayaka Ozawa, Naoki Nishida, Neil E. Bowles, Fukiko Ichida. Clinical and Echocardiographic Impact of Tafazzin Variants on Dilated Cardiomyopathy Phenotype in Left Ventricular Non-Compaction Patients in Early Infancy. Circulation Journal. 2018; 82 (10):2609-2618.

Chicago/Turabian Style

Keiichi Hirono; Yukiko Hata; Makoto Nakazawa; Nobuo Momoi; Tohru Tsuji; Taro Matsuoka; Mamoru Ayusawa; Yuriko Abe; Tamaki Hayashi; Nobuyuki Tsujii; Tadaaki Abe; Heima Sakaguchi; Ce Wang; Asami Takasaki; Shinya Takarada; Mako Okabe; Nariaki Miyao; Hideyuki Nakaoka; Keijiro Ibuki; Kazuyoshi Saito; Sayaka Ozawa; Naoki Nishida; Neil E. Bowles; Fukiko Ichida. 2018. "Clinical and Echocardiographic Impact of Tafazzin Variants on Dilated Cardiomyopathy Phenotype in Left Ventricular Non-Compaction Patients in Early Infancy." Circulation Journal 82, no. 10: 2609-2618.

Practice guideline
Published: 24 August 2018 in Circulation Journal
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Naokata Sumitomo; Reizo Baba; Shozaburo Doi; Takashi Higaki; Hitoshi Horigome; Fukiko Ichida; Hiromi Ishikawa; Mari Iwamoto; Naomi Izumida; Yuji Kasamaki; Keisuke Kuga; Yoshihide Mitani; Haruki Musha; Toshio Nakanishi; Masao Yoshinaga; Katsumi Abe; Mamoru Ayusawa; Tatsunori Hokosaki; Taichi Kato; Yoshiaki Kato; Kunio Ohta; Hirofumi Sawada; Hiroya Ushinohama; Shigeki Yoshiba; Hirotsugu Atarashi; Atsushi Hirayama; Minoru Horie; Masami Nagashima; Koichiro Niwa; Shunichi Ogawa; Ken Okumura; Hiroyuki Tsutsui; On Behalf Of The Japanese Circulation Society And The Japanese Society Of Pediatric Cardiology And Cardiac Surgery Of Joint Working. Guidelines for Heart Disease Screening in Schools (JCS 2016/JSPCCS 2016) ― Digest Version ―. Circulation Journal 2018, 82, 2385 -2444.

AMA Style

Naokata Sumitomo, Reizo Baba, Shozaburo Doi, Takashi Higaki, Hitoshi Horigome, Fukiko Ichida, Hiromi Ishikawa, Mari Iwamoto, Naomi Izumida, Yuji Kasamaki, Keisuke Kuga, Yoshihide Mitani, Haruki Musha, Toshio Nakanishi, Masao Yoshinaga, Katsumi Abe, Mamoru Ayusawa, Tatsunori Hokosaki, Taichi Kato, Yoshiaki Kato, Kunio Ohta, Hirofumi Sawada, Hiroya Ushinohama, Shigeki Yoshiba, Hirotsugu Atarashi, Atsushi Hirayama, Minoru Horie, Masami Nagashima, Koichiro Niwa, Shunichi Ogawa, Ken Okumura, Hiroyuki Tsutsui, On Behalf Of The Japanese Circulation Society And The Japanese Society Of Pediatric Cardiology And Cardiac Surgery Of Joint Working. Guidelines for Heart Disease Screening in Schools (JCS 2016/JSPCCS 2016) ― Digest Version ―. Circulation Journal. 2018; 82 (9):2385-2444.

Chicago/Turabian Style

Naokata Sumitomo; Reizo Baba; Shozaburo Doi; Takashi Higaki; Hitoshi Horigome; Fukiko Ichida; Hiromi Ishikawa; Mari Iwamoto; Naomi Izumida; Yuji Kasamaki; Keisuke Kuga; Yoshihide Mitani; Haruki Musha; Toshio Nakanishi; Masao Yoshinaga; Katsumi Abe; Mamoru Ayusawa; Tatsunori Hokosaki; Taichi Kato; Yoshiaki Kato; Kunio Ohta; Hirofumi Sawada; Hiroya Ushinohama; Shigeki Yoshiba; Hirotsugu Atarashi; Atsushi Hirayama; Minoru Horie; Masami Nagashima; Koichiro Niwa; Shunichi Ogawa; Ken Okumura; Hiroyuki Tsutsui; On Behalf Of The Japanese Circulation Society And The Japanese Society Of Pediatric Cardiology And Cardiac Surgery Of Joint Working. 2018. "Guidelines for Heart Disease Screening in Schools (JCS 2016/JSPCCS 2016) ― Digest Version ―." Circulation Journal 82, no. 9: 2385-2444.

Journal article
Published: 06 August 2018 in Cardiology in the Young
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BackgroundThere is no standard dose or protocol for beta-blocker administration as preconditioning in children undergoing coronary CT angiography.MethodsA total of 63 consecutive patients, with a mean age of 10.0±3.1 years, who underwent coronary CT angiography to assess possible coronary complications were enrolled in a single-centre, retrospective study. All patients were given an oral beta-blocker 1 hour before coronary CT angiography. Additional oral beta-blocker or intravenous beta-blocker was given to those with a high heart rate. We compared image quality, radiation exposure, and adverse events among the patients without additional beta-blocker, with additional oral beta-blocker, and with additional intravenous beta-blocker.ResultsThere were no significant differences in image quality or radiation exposure among the groups. The heart rate just before scanning was significantly correlated with image quality (pConclusionInitial oral beta-blocker administration (0.8 mg/kg/dose) should be administered to all children undergoing coronary CT angiography. Additional intravenous beta-blocker should be given to those with poor heart rate control to improve image quality without increasing radiation exposure or allowing adverse events.

ACS Style

Hirofumi Watanabe; Hiroshi Kamiyama; Masataka Kato; Akiko Komori; Yuriko Abe; Mamoru Ayusawa. Appropriate use of a beta-blocker in paediatric coronary CT angiography. Cardiology in the Young 2018, 28, 1148 -1153.

AMA Style

Hirofumi Watanabe, Hiroshi Kamiyama, Masataka Kato, Akiko Komori, Yuriko Abe, Mamoru Ayusawa. Appropriate use of a beta-blocker in paediatric coronary CT angiography. Cardiology in the Young. 2018; 28 (10):1148-1153.

Chicago/Turabian Style

Hirofumi Watanabe; Hiroshi Kamiyama; Masataka Kato; Akiko Komori; Yuriko Abe; Mamoru Ayusawa. 2018. "Appropriate use of a beta-blocker in paediatric coronary CT angiography." Cardiology in the Young 28, no. 10: 1148-1153.

Journal article
Published: 25 March 2018 in Pediatrics International
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Discussion of health care transition (HCT) for adults with a childhood history of coronary artery lesions (CAL) after Kawasaki disease (KD) is important. A nationwide questionnaire survey was performed with support by the Japanese Society of Kawasaki Disease. The purpose of this study is to clarify the reality of HCT and loss to follow-up in patients with CAL after KD. The survey was e-mailed to 48 members of the Japanese Society of Kawasaki Disease from May to July 2014. Forty surveys were collected, giving a respondent rate of 83.3%. Fifty-four percent of the respondents belonged to a university hospital. Approximately 90% of the respondents dealt with patients who needed HCT, and 55% had patients who completed HCT. Approximately 70% of the respondents considered that pediatricians should continue sharing HCT information with cardiologists. More than 95% of the respondents had a favorable or average impression of HCT care provided by cardiologists. The percentage of respondents lost to follow-up for HCT was not less than 40%. Adult cardiologists began managing patients with CAL after KD in more than half of the institutes in this study. Pediatricians should construct a support program for better management of these patients and for cooperation with cardiologists to prevent loss to follow-up. This article is protected by copyright. All rights reserved.

ACS Style

Hiroshi Kamiyama; Mamoru Ayusawa; Shunichi Ogawa; Tsutomu Saji; Kenji Hamaoka. Health-care transition after Kawasaki disease in patients with coronary artery lesion. Pediatrics International 2018, 60, 232 -239.

AMA Style

Hiroshi Kamiyama, Mamoru Ayusawa, Shunichi Ogawa, Tsutomu Saji, Kenji Hamaoka. Health-care transition after Kawasaki disease in patients with coronary artery lesion. Pediatrics International. 2018; 60 (3):232-239.

Chicago/Turabian Style

Hiroshi Kamiyama; Mamoru Ayusawa; Shunichi Ogawa; Tsutomu Saji; Kenji Hamaoka. 2018. "Health-care transition after Kawasaki disease in patients with coronary artery lesion." Pediatrics International 60, no. 3: 232-239.

Clinical trial
Published: 22 March 2018 in Pediatrics International
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IT is well known that serum N-terminal pro brain natriuretic peptide (NT-proBNP) tends to elevate in acute phase of Kawasaki disease (KD), but the cause of NT-proBNP elevation has not been clarified. Our previous study revealed that cardiac function evaluated by two-dimensional echocardiography (2D-E) such as ejection fraction (EF) was normal. However, cardiac function evaluated by 2D-E does not reflect subtle change of cardiac dysfunction and the relation has still been controversial. Our purpose is to obtain definite conclusion of the influence of cardiac function on NT-proBNP elevation, we introduced strain evaluated cardiac function by three-dimensional speckle tracking imaging (3DSTI) and tested in acute and subacute phase of KD patients. As cytokines were also thought to introduce NT-proBNP in acute phase of KD, serum cytokines and cytokine receptors were measured at the same time. Results of laboratory testing and echocardiography in 52 KD patients in the acute and subacute phases were reviewed. NT-proBNP was significantly elevated in the acute phase compared with the subacute phase (356.5 pg/mL, IQR: 145–904 pg/mL vs 103.5 pg/mL, IQR: 59-150 pg/mL, P < 0.01).. All cytokines were also significantly elevated in the acute phase compared with the subacute phase. Concentrations of tumor necrosis factor (TNF)-α, soluble TNF receptors (sTNFR)1, and sTNFR2 were all significantly higher in the acute phase. Indices of cardiac functions showed no significant difference between phases. NT-proBNP in the acute and subacute phases correlated with sTNFR1 (r = 0.63/0.43, P < 0.01), sTNFR2 (r = 0.50/0.31, P < 0.05), and IL-6 (r = 0.58/0.43, P < 0.01). NT-proBNP did not correlated with global longitudinal strain (GLS) on 3D-STI. While no correlations between NT-proBNP and GLS by 3D-STI were apparent, correlations between NT-proBNP and cytokines were distinct. NT-proBNP might offer a marker of inflammation in KD, but is not a marker of cardiac function. This article is protected by copyright. All rights reserved.

ACS Style

Masataka Kato; Mamoru Ayusawa; Hirofumi Watanabe; Akiko Komori; Yuriko Abe; Takahiro Nakamura; Hiroshi Kamiyama; Shori Takahashi. Cardiac function on 3-D speckle tracking imaging and cytokines in Kawasaki disease. Pediatrics International 2018, 60, 342 -348.

AMA Style

Masataka Kato, Mamoru Ayusawa, Hirofumi Watanabe, Akiko Komori, Yuriko Abe, Takahiro Nakamura, Hiroshi Kamiyama, Shori Takahashi. Cardiac function on 3-D speckle tracking imaging and cytokines in Kawasaki disease. Pediatrics International. 2018; 60 (4):342-348.

Chicago/Turabian Style

Masataka Kato; Mamoru Ayusawa; Hirofumi Watanabe; Akiko Komori; Yuriko Abe; Takahiro Nakamura; Hiroshi Kamiyama; Shori Takahashi. 2018. "Cardiac function on 3-D speckle tracking imaging and cytokines in Kawasaki disease." Pediatrics International 60, no. 4: 342-348.

Case reports
Published: 14 August 2017 in Pediatrics International
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Akiko Komori; Mamoru Ayusawa; Masataka Kato; Takahiro Nakamura; Shori Takahashi. Congenital complete atrioventricular block with pulmonary hypertension. Pediatrics International 2017, 59, 1095 -1096.

AMA Style

Akiko Komori, Mamoru Ayusawa, Masataka Kato, Takahiro Nakamura, Shori Takahashi. Congenital complete atrioventricular block with pulmonary hypertension. Pediatrics International. 2017; 59 (10):1095-1096.

Chicago/Turabian Style

Akiko Komori; Mamoru Ayusawa; Masataka Kato; Takahiro Nakamura; Shori Takahashi. 2017. "Congenital complete atrioventricular block with pulmonary hypertension." Pediatrics International 59, no. 10: 1095-1096.

Journal article
Published: 01 January 2017 in Journal of Nihon University Medical Association
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Despite having undergone mandatory PCV7 vaccinations, three young children were hospitalized with invasive pneumococcal infections. Among them, two cases were diagnosed as having meningitis and one had bacteremia. Serotype ‘15A’ in one meningitis case was outside the range covered by PCV7 and PCV13 vaccinations, and that case was fatal. Voluntary PCV13 vaccination has been in place in Japan since autumn 2013; however, serotype replacement with uncovered serotypes is a possibility that physicians should consider.

ACS Style

Naohide Kin; Mamoru Ayusawa; Nobuhiko Nagano; Ryuta Yonezawa; Maki Furukawa; Yasuji Inamo; Shori Takahashi. Three Cases of Invasive Pneumococcal Disease with Multiple Serotype Replacement in Vaccinated Children. Journal of Nihon University Medical Association 2017, 76, 215 -217.

AMA Style

Naohide Kin, Mamoru Ayusawa, Nobuhiko Nagano, Ryuta Yonezawa, Maki Furukawa, Yasuji Inamo, Shori Takahashi. Three Cases of Invasive Pneumococcal Disease with Multiple Serotype Replacement in Vaccinated Children. Journal of Nihon University Medical Association. 2017; 76 (5):215-217.

Chicago/Turabian Style

Naohide Kin; Mamoru Ayusawa; Nobuhiko Nagano; Ryuta Yonezawa; Maki Furukawa; Yasuji Inamo; Shori Takahashi. 2017. "Three Cases of Invasive Pneumococcal Disease with Multiple Serotype Replacement in Vaccinated Children." Journal of Nihon University Medical Association 76, no. 5: 215-217.

Journal article
Published: 01 January 2017 in Journal of Nihon University Medical Association
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超低出生体重 (ELBWI),慢性肺疾患 (CLD) に伴う肺高血圧 (PH) の既往のある8 か月男児について報告する.外来定期受診時にPH クリーゼとなり蘇生を要した.肺血管拡張薬を導入しPH は改善し,在宅酸素で退院した.ELBWI には高率にCLD を合併し,本症例のような重症例ではPH のため予後不良となる患者が存在する.ルーチンの心臓超音波検査だけでは過小評価となる可能性があり,適切なリスクの評価とさらなる注意深いフォローが求められる.

ACS Style

Masaru Ueno; Takahiro Nakamura; Michiko Yamada; Hirofumi Watanabe; Masataka Kato; Akiko Komori; Kengo Kawamura; Yousuke Taguchi; Mamoru Ayusawa; Shori Takahashi. A Case of Pulmonary Hypertension Crisis in an Extremely Low Birth Weight Infant that Developed at a Scheduled Outpatient Visit. Journal of Nihon University Medical Association 2017, 76, 289 -292.

AMA Style

Masaru Ueno, Takahiro Nakamura, Michiko Yamada, Hirofumi Watanabe, Masataka Kato, Akiko Komori, Kengo Kawamura, Yousuke Taguchi, Mamoru Ayusawa, Shori Takahashi. A Case of Pulmonary Hypertension Crisis in an Extremely Low Birth Weight Infant that Developed at a Scheduled Outpatient Visit. Journal of Nihon University Medical Association. 2017; 76 (6):289-292.

Chicago/Turabian Style

Masaru Ueno; Takahiro Nakamura; Michiko Yamada; Hirofumi Watanabe; Masataka Kato; Akiko Komori; Kengo Kawamura; Yousuke Taguchi; Mamoru Ayusawa; Shori Takahashi. 2017. "A Case of Pulmonary Hypertension Crisis in an Extremely Low Birth Weight Infant that Developed at a Scheduled Outpatient Visit." Journal of Nihon University Medical Association 76, no. 6: 289-292.

Book chapter
Published: 28 August 2016 in Kawasaki Disease
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Kawasaki disease (KD) is diagnosed on the basis of six characteristic symptoms, and several reference findings are used to confirm the diagnosis. Most patients are younger than 5 years. Fever is the first sign of KD in most patients, and although Japanese guidelines give equal weight to fever and the other five symptoms, the American Heart Association guidelines regard fever as indispensable to a KD diagnosis. The other principal signs are bilateral bulbar conjunctival injection, changes in the lips and oral cavity, polymorphous exanthema, changes in the extremities (including membranous desquamation from the fingertips), and cervical lymphadenopathy, which is less frequent than the other five symptoms. If KD is suspected in a patient with four or fewer principal symptoms, incomplete KD is diagnosed. Careful differential diagnosis is necessary in such cases because patients with incomplete KD can develop coronary artery aneurysms.

ACS Style

Mamoru Ayusawa; Keiji Tsuchiya. Diagnosis and Characteristics of Typical and Incomplete Kawasaki Disease. Kawasaki Disease 2016, 255 -269.

AMA Style

Mamoru Ayusawa, Keiji Tsuchiya. Diagnosis and Characteristics of Typical and Incomplete Kawasaki Disease. Kawasaki Disease. 2016; ():255-269.

Chicago/Turabian Style

Mamoru Ayusawa; Keiji Tsuchiya. 2016. "Diagnosis and Characteristics of Typical and Incomplete Kawasaki Disease." Kawasaki Disease , no. : 255-269.

Book chapter
Published: 28 August 2016 in Kawasaki Disease
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Almost all patients with Kawasaki disease take aspirin for 2–3 months after disease onset. During and after such treatment, patients without coronary artery lesions (CAL) are not restricted with respect to sports, vaccination, or normal daily life activities. Management of daily life activities of patients with CAL depends on individual risk of cardiac events, as determined by appropriate assessment techniques. If the patient requires anticoagulant and/or antiplatelet treatment, external injuries should be avoided and participation in contact sports restricted. When warfarin is used, the dose needs to be carefully monitored by blood testing, and the patient should be informed about foods that increase vitamin K levels. Angiograms obtained by computed tomography or magnetic resonance are beginning to supplant catheter angiograms in the morphological evaluation of CAL; however, these modalities have advantages and disadvantages. Echocardiography and scintigraphy with pharmacological or exercise stress testing is useful in functional studies. However, an experienced examiner must be available to conduct and evaluate the results of such tests. As patients age, they must be made aware of the possibility of cardiac sequelae and the need for transition to an adult cardiologist.

ACS Style

Mamoru Ayusawa. Long-Term Follow-Up and Education Regarding Daily Life Activities, School Life, and Guidelines After Acute KD. Kawasaki Disease 2016, 297 -301.

AMA Style

Mamoru Ayusawa. Long-Term Follow-Up and Education Regarding Daily Life Activities, School Life, and Guidelines After Acute KD. Kawasaki Disease. 2016; ():297-301.

Chicago/Turabian Style

Mamoru Ayusawa. 2016. "Long-Term Follow-Up and Education Regarding Daily Life Activities, School Life, and Guidelines After Acute KD." Kawasaki Disease , no. : 297-301.

Journal article
Published: 14 July 2016 in Pediatrics International
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Tumor necrosis factor-α may cause NT-proBNP elevation in the acute phase of KD, and NT-proBNP level may be an indicator of TNF-α activity.

ACS Style

Daisuke Yanagisawa; Mamoru Ayusawa; Masataka Kato; Hirofumi Watanabe; Akiko Komori; Yuriko Abe; Takahiro Nakamura; Hiroshi Kamiyama; Shori Takahashi; Nakamura Takahiro. Factors affecting N-terminal pro-brain natriuretic peptide elevation in the acute phase of Kawasaki disease. Pediatrics International 2016, 58, 1105 -1111.

AMA Style

Daisuke Yanagisawa, Mamoru Ayusawa, Masataka Kato, Hirofumi Watanabe, Akiko Komori, Yuriko Abe, Takahiro Nakamura, Hiroshi Kamiyama, Shori Takahashi, Nakamura Takahiro. Factors affecting N-terminal pro-brain natriuretic peptide elevation in the acute phase of Kawasaki disease. Pediatrics International. 2016; 58 (11):1105-1111.

Chicago/Turabian Style

Daisuke Yanagisawa; Mamoru Ayusawa; Masataka Kato; Hirofumi Watanabe; Akiko Komori; Yuriko Abe; Takahiro Nakamura; Hiroshi Kamiyama; Shori Takahashi; Nakamura Takahiro. 2016. "Factors affecting N-terminal pro-brain natriuretic peptide elevation in the acute phase of Kawasaki disease." Pediatrics International 58, no. 11: 1105-1111.

Case reports
Published: 28 October 2015 in Pediatrics International
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We report the case of a 9-year-old girl with Down syndrome (DS) diagnosed with idiopathic pulmonary hemosiderosis (IPH). Although acute pneumonia complicated by hemolytic anemia was suspected, IPH was finally diagnosed on bronchoscopy. Treatment with prednisolone achieved good clinical response. An association between IPH and DS was not able to be identified, but immunological issues in DS may contribute to the onset of IPH. Recurrent and intractable respiratory symptoms with marked infiltrative shadows in the bilateral lungs and complicated by severe anemia in patients with DS should suggest IPH.

ACS Style

Hirofumi Watanabe; Mamoru Ayusawa; Masataka Kato; Ami Chou; Akiko Komori; Yuriko Abe; Masaharu Matsumura; Hiroshi Kamiyama; Hiroyuki Izumi; Shori Takahashi. Idiopathic pulmonary hemosiderosis complicated by Down syndrome. Pediatrics International 2015, 57, 1009 -1012.

AMA Style

Hirofumi Watanabe, Mamoru Ayusawa, Masataka Kato, Ami Chou, Akiko Komori, Yuriko Abe, Masaharu Matsumura, Hiroshi Kamiyama, Hiroyuki Izumi, Shori Takahashi. Idiopathic pulmonary hemosiderosis complicated by Down syndrome. Pediatrics International. 2015; 57 (5):1009-1012.

Chicago/Turabian Style

Hirofumi Watanabe; Mamoru Ayusawa; Masataka Kato; Ami Chou; Akiko Komori; Yuriko Abe; Masaharu Matsumura; Hiroshi Kamiyama; Hiroyuki Izumi; Shori Takahashi. 2015. "Idiopathic pulmonary hemosiderosis complicated by Down syndrome." Pediatrics International 57, no. 5: 1009-1012.

Case reports
Published: 01 October 2015 in Cardiology in the Young
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Fatal arrhythmias in asymptomatic Kawasaki disease patients with normal left ventricular function have rarely been reported. In this study, we report the cases of two adult patients with largely unpredictable sudden cardiac arrest, despite almost-normal left ventricular function even after the diagnosis of presumed Kawasaki disease, as well as consider the mechanisms involved with reference to the literature.

ACS Style

Hirofumi Watanabe; Masataka Kato; Mamoru Ayusawa. Potentially fatal arrhythmias in two cases of adult Kawasaki disease. Cardiology in the Young 2015, 26, 602 -604.

AMA Style

Hirofumi Watanabe, Masataka Kato, Mamoru Ayusawa. Potentially fatal arrhythmias in two cases of adult Kawasaki disease. Cardiology in the Young. 2015; 26 (3):602-604.

Chicago/Turabian Style

Hirofumi Watanabe; Masataka Kato; Mamoru Ayusawa. 2015. "Potentially fatal arrhythmias in two cases of adult Kawasaki disease." Cardiology in the Young 26, no. 3: 602-604.

Journal article
Published: 04 September 2015 in SpringerPlus
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Previous studies that used carotid ultrasound have been largely conflicting in regards to whether or not patients after Kawasaki disease (KD) have a greater carotid intima-media thickness (CIMT) than controls. To test the hypothesis that there are significant differences between the values of CIMT expressed as absolute values and standard deviation scores (SDS) in children and adolescents after KD and controls, we reviewed 12 published articles regarding CIMT on KD patients and controls. The mean ± SD of absolute CIMT (mm) in the KD patients and controls obtained from each article was transformed to SDS (CIMT-SDS) using age-specific reference values established by Jourdan et al. (J: n = 247) and our own data (N: n = 175), and the results among these 12 articles were compared between the two groups and the references for comparison of racial disparities. There were no significant differences in mean absolute CIMT and mean CIMT-SDS for J between KD patients and controls (0.46 ± 0.06 mm vs. 0.44 ± 0.04 mm, p = 0.133, and 1.80 ± 0.84 vs. 1.25 ± 0.12, p = 0.159, respectively). However, there were significant differences in mean CIMT-SDS for N between KD patients and controls (0.60 ± 0.71 vs. 0.01 ± 0.65, p = 0.042). When we assessed the nine articles on Asian subjects, the difference of CIMT-SDS between the two groups was invariably significant only for N (p = 0.015). Compared with the reference values, CIMT-SDS of controls was within the normal range at a rate of 41.6 % for J and 91.6 % for N. These results indicate that age- and race-specific reference values for CIMT are mandatory for performing accurate assessment of the vascular status in healthy children and adolescents, particularly in those after KD considered at increased long-term cardiovascular risk.

ACS Style

Nobutaka Noto; Masataka Kato; Yuriko Abe; Hiroshi Kamiyama; Kensuke Karasawa; Mamoru Ayusawa; Shori Takahashi. Reassessment of carotid intima-media thickness by standard deviation score in children and adolescents after Kawasaki disease. SpringerPlus 2015, 4, 479 .

AMA Style

Nobutaka Noto, Masataka Kato, Yuriko Abe, Hiroshi Kamiyama, Kensuke Karasawa, Mamoru Ayusawa, Shori Takahashi. Reassessment of carotid intima-media thickness by standard deviation score in children and adolescents after Kawasaki disease. SpringerPlus. 2015; 4 (1):479.

Chicago/Turabian Style

Nobutaka Noto; Masataka Kato; Yuriko Abe; Hiroshi Kamiyama; Kensuke Karasawa; Mamoru Ayusawa; Shori Takahashi. 2015. "Reassessment of carotid intima-media thickness by standard deviation score in children and adolescents after Kawasaki disease." SpringerPlus 4, no. 1: 479.