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Hui Shen
Department of Public Health, Shihezi University School of Medicine, Shihezi 832000, Xinjiang, China.

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Review
Published: 06 February 2016 in International Journal of Environmental Research and Public Health
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Chronic arsenic exposure is a critical public health issue in many countries. The metabolism of arsenic in vivo is complicated because it can be influenced by many factors. In the present meta-analysis, two researchers independently searched electronic databases, including the Cochrane Library, PubMed, Springer, Embase, and China National Knowledge Infrastructure, to analyze factors influencing arsenic methylation. The concentrations of the following arsenic metabolites increase (p< 0.000001) following arsenic exposure: inorganic arsenic (iAs), monomethyl arsenic (MMA), dimethyl arsenic (DMA), and total arsenic. Additionally, the percentages of iAs (standard mean difference (SMD): 1.00; 95% confidence interval (CI): 0.60–1.40; p< 0.00001) and MMA (SMD: 0.49; 95% CI: 0.21–0.77; p = 0.0006) also increase, while the percentage of DMA (SMD: −0.57; 95% CI: −0.80–−0.31; p< 0.0001), primary methylation index (SMD: −0.57; 95% CI: −0.94–−0.20; p = 0.002), and secondary methylation index (SMD: −0.27; 95% CI: −0.46–−0.90; p = 0.004) decrease. Smoking, drinking, and older age can reduce arsenic methylation, and arsenic methylation is more efficient in women than in men. The results of this analysis may provide information regarding the role of arsenic oxidative methylation in the arsenic poisoning process.

ACS Style

Hui Shen; Qiang Niu; Mengchuan Xu; Dongsheng Rui; Shangzhi Xu; Gangling Feng; Yusong Ding; Shugang Li; Mingxia Jing. Factors Affecting Arsenic Methylation in Arsenic-Exposed Humans: A Systematic Review and Meta-Analysis. International Journal of Environmental Research and Public Health 2016, 13, 205 .

AMA Style

Hui Shen, Qiang Niu, Mengchuan Xu, Dongsheng Rui, Shangzhi Xu, Gangling Feng, Yusong Ding, Shugang Li, Mingxia Jing. Factors Affecting Arsenic Methylation in Arsenic-Exposed Humans: A Systematic Review and Meta-Analysis. International Journal of Environmental Research and Public Health. 2016; 13 (2):205.

Chicago/Turabian Style

Hui Shen; Qiang Niu; Mengchuan Xu; Dongsheng Rui; Shangzhi Xu; Gangling Feng; Yusong Ding; Shugang Li; Mingxia Jing. 2016. "Factors Affecting Arsenic Methylation in Arsenic-Exposed Humans: A Systematic Review and Meta-Analysis." International Journal of Environmental Research and Public Health 13, no. 2: 205.