We are focused on the study of: a) modulation of nicotinic acetylcholine receptors by antidepressants and new synthetic compounds, and b) the roles of glial cells in synaptic transmission and the action of antidepressants. Our interest is to study the mechanisms of action and sites of interaction of some antidepressants (fluoxetine, norfluoxetine, imipramine, and escitalopram, among others) with neuronal nicotinic receptors. Likewise, we are interested in the study of new synthetic compounds as possible modulators of nicotinic receptors. Additionally, we are interested in studying how early stress in rats affects their behavior during youth and adulthood, as well as the possible roles of astrocytes in neuronal excitatory and inhibitory synaptic transmission in the prefrontal cortex. We use mainly electrophysiological, behavioral, and in silico approaches.