In the title molecular salt, C₈H₂₀N⁺·C₄₂H₄₈NO₄S₄⁻, the conformation of the anionic tetrathiacalix[4]arene, which is cone-shaped, is primarily determined by intramolecular O—H...O hydrogen bonds. There are also intramolecular C—H...O short contacts present. In the crystal, the anions (A) and cations (C) are linked by C—H...O and C—H...S hydrogen bonds, forming –A–C–A–C– chains along [001]. The chains are linkedviaC—H...N_cyanohydrogen bonds, forming ribbons along [001].