The escalating global health crisis of antibiotic resistance, driven by the rapid emergence of multidrug-resistant (MDR) bacterial pathogens, necessitates urgent and innovative countermeasures. This review comprehensively examines the diverse mechanisms employed by bacteria to evade antibiotic action, including alterations in cell membrane permeability, efflux pump overexpression, biofilm formation, target site modifications, and the enzymatic degradation of antibiotics. Specific focus is given to membrane transport systems such as ATP-binding cassette (ABC) transporters, resistance–nodulation–division (RND) efflux pumps, major facilitator superfamily (MFS) transporters, multidrug and toxic compound extrusion (MATE) systems, small multidrug resistance (SMR) families, and proteobacterial antimicrobial compound efflux (PACE) families. Additionally, the review explores the global burden of MDR pathogens and evaluates emerging therapeutic strategies, including quorum quenching (QQ), probiotics, postbiotics, synbiotics, antimicrobial peptides (AMPs), stem cell applications, immunotherapy, antibacterial photodynamic therapy (aPDT), and bacteriophage. Furthermore, this review discusses novel antimicrobial agents, such as animal-venom-derived compounds and nanobiotics, as promising alternatives to conventional antibiotics. The interplay between clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated proteins (Cas) in bacterial adaptive immunity is analyzed, revealing opportunities for targeted genetic interventions. By synthesizing current advancements and emerging strategies, this review underscores the necessity of interdisciplinary collaboration among biomedical scientists, researchers, and the pharmaceutical industry to drive the development of novel antibacterial agents. Ultimately, this comprehensive analysis provides a roadmap for future research, emphasizing the urgent need for sustainable and cooperative approaches to combat antibiotic resistance and safeguard global health.

Bioactive molecules derived from seaweed extracts are revolutionary bio-stimulants used to enhance plant growth and increase yield production. This study evaluated the effectiveness of a commercially available seaweed liquid extract, namely, True-Algae-Max (TAM^®), as a plant growth stimulant on nutritional, and antioxidant activity of Capsicum annuum. Three concentrations of TAM^® (0.25, 0.5, and 1%) of various NPK: TAM^® ratios were investigated via foliar spray, over 2017 and 2018 cultivation seasons, under greenhouse conditions. TAM^® is rich in phytochemical compounds, such as ascorbic acid (1.66 mg g⁻¹), phenolics (101.67 mg g⁻¹), and flavonoids (2.60 mg g⁻¹) that showed good antioxidant activity (54.52 mg g⁻¹) and DPPH inhibition of 70.33%. Promoting measured parameter results stated the extensive potentiality of TAM^® application, in comparison with conventional NPK treatment. Yield and composition of C. annuum were significantly improved in all TAM^® treated groups, especially the TAM_0.5% concentration, which resulted in maximum yield (4.23 Kg m⁻²) and significant amounts of profuse biological molecules like chlorophyll, ascorbic, phenolic compounds, flavonoids, and total nutrients. Compared to the NPK control treatments, C. annuum treated with TAM_0.5% improved the total antioxidant activity of hot Pepper from 162.16 to 190.95 mg g⁻¹. These findings indicate that the extract of seaweed can be used as an environmentally friendly, multi-functional biostimulant in the agricultural field for more sustainable production, in addition to reducing the use of hazardous synthetic fertilizers.

To address climate change threats to ecosystems and the global economy, sustainable solutions for reducing atmospheric carbon dioxide (CO₂) levels are crucial. Existing CO₂capture projects face challenges like high costs and environmental risks. This review explores leveraging microalgae, specifically theChlorellagenus, for CO₂capture and conversion into valuable bioenergy products like biohydrogen. The introduction section provides an overview of carbon pathways in microalgal cells and their role in CO₂capture for biomass production. It discusses current carbon credit industries and projects, highlighting theChlorellagenus’s carbon concentration mechanism (CCM) model for efficient CO₂sequestration. Factors influencing microalgal CO₂sequestration are examined, including pretreatment, pH, temperature, irradiation, nutrients, dissolved oxygen, and sources and concentrations of CO₂. The review explores microalgae as a feedstock for various bioenergy applications like biodiesel, biooil, bioethanol, biogas and biohydrogen production. Strategies for optimizing biohydrogen yield fromChlorellaare highlighted. Outlining the possibilities of further optimizations the review concludes by suggesting that microalgae andChlorella-based CO₂capture is promising and offers contributions to achieve global climate goals.