Pesticides are widely used in agricultural production to prevent or control pests, diseases, weeds, and other plant pathogens in an effort to reduce or eliminate yield losses and maintain high product quality. Although pesticides are developed through very strict regulation processes to function with reasonable certainty and minimal impact on human health and the environment, serious concerns have been raised about health risks resulting from occupational exposure and from residues in food and drinking water. Occupational exposure to pesticides often occurs in the case of agricultural workers in open fields and greenhouses, workers in the pesticide industry, and exterminators of house pests. Exposure of the general population to pesticides occurs primarily through eating food and drinking water contaminated with pesticide residues, whereas substantial exposure can also occur in or around the home. Regarding the adverse effects on the environment (water, soil and air contamination from leaching, runoff, and spray drift, as well as the detrimental effects on wildlife, fish, plants, and other non-target organisms), many of these effects depend on the toxicity of the pesticide, the measures taken during its application, the dosage applied, the adsorption on soil colloids, the weather conditions prevailing after application, and how long the pesticide persists in the environment. Therefore, the risk assessment of the impact of pesticides either on human health or on the environment is not an easy and particularly accurate process because of differences in the periods and levels of exposure, the types of pesticides used (regarding toxicity and persistence), and the environmental characteristics of the areas where pesticides are usually applied. Also, the number of the criteria used and the method of their implementation to assess the adverse effects of pesticides on human health could affect risk assessment and would possibly affect the characterization of the already approved pesticides and the approval of the new compounds in the near future. Thus, new tools or techniques with greater reliability than those already existing are needed to predict the potential hazards of pesticides and thus contribute to reduction of the adverse effects on human health and the environment. On the other hand, the implementation of alternative cropping systems that are less dependent on pesticides, the development of new pesticides with novel modes of action and improved safety profiles, and the improvement of the already used pesticide formulations towards safer formulations (e.g., microcapsule suspensions) could reduce the adverse effects of farming and particularly the toxic effects of pesticides. In addition, the use of appropriate and well-maintained spraying equipment along with taking all precautions that are required in all stages of pesticide handling could minimize human exposure to pesticides and their potential adverse effects on the environment.

Synthetic pesticides are extensively used in agriculture to control harmful pests and prevent crop yield losses or product damage. Because of high biological activity and, in certain cases, long persistence in the environment, pesticides may cause undesirable effects to human health and to the environment. Farmers are routinely exposed to high levels of pesticides, usually much greater than those of consumers. Farmers’ exposure mainly occurs during the preparation and application of the pesticide spray solutions and during the cleaning-up of spraying equipment. Farmers who mix, load, and spray pesticides can be exposed to these chemicals due to spills and splashes, direct spray contact as a result of faulty or missing protective equipment, or even drift. However, farmers can be also exposed to pesticides even when performing activities not directly related to pesticide use. Farmers who perform manual labor in areas treated with pesticides can face major exposure from direct spray, drift from neighboring fields, or by contact with pesticide residues on the crop or soil. This kind of exposure is often underestimated. The dermal and inhalation routes of entry are typically the most common routes of farmers’ exposure to pesticides. Dermal exposure during usual pesticide handling takes place in body areas that remain uncovered by protective clothing, such as the face and the hands. Farmers’ exposure to pesticides can be reduced through less use of pesticides and through the correct use of the appropriate type of personal protective equipment in all stages of pesticide handling.

Biopesticides have attracted attention in pest management in recent decades, and have long been promoted as prospective alternatives to synthetic pesticides. Biopesticides have also attracted great interest in the international research community, with a significant increase in the number of publications devoted to the subject. Recently, new substances, like strains of the fungus Talaromyces flavus SAY-Y-94-01, extracts of the plant Clitoria ternatea (butterfly pea), products of the fungus Trichoderma harzianum, products of the bacterium Bacillus thuringiensis var. tenebrionis strain Xd3 (Btt-Xd3), the alkaloid compound oxymatrine, fermentation products of the bacterium Lactobacillus casei strain LPT-111, stilbenes accumulated in grape canes, and olive mill wastes, have been reported in the literature as promising compounds for use as biopesticides, but more field research is required to assess the effects on specific pest problems under diverse cropping systems. Nevertheless, biopesticides have not yet reached the desired level of use, whereby they could displace the dominance of chemical pesticides, given that the commercialization of new products in the market is lagging behind. Currently, biopesticides comprise a small share of the total crop protection market globally, with a value of about $3 billion worldwide, accounting for just 5% of the total crop protection market. Fewer biopesticide-active substances are registered in the European Union (EU) than in the United States, India, Brazil, or China, due to long and complex registration processes in the EU, which follow the model for the registration of conventional pesticides. Nanoformulations and microencapsulation technologies can improve the stability and residual action of biopesticide products, and this could increase their field use. Regulations that promote registration of low-risk compounds with the provision of incentives could also facilitate commercialization and availability of biopesticides in the market.