Breast cancer is one of the main causes of cancer death worldwide. The diagnosis of biopsy tissue with hematoxylin and eosin stained images is non-trivial and specialists often disagree on the final diagnosis. Computer-aided Diagnosis systems contribute to reduce the cost and increase the efficiency of this process. Conventional classification approaches rely on feature extraction methods designed for a specific problem based on field-knowledge. To overcome the many difficulties of the feature-based approaches, deep learning methods are becoming important alternatives. A method for the classification of hematoxylin and eosin stained breast biopsy images using Convolutional Neural Networks (CNNs) is proposed. Images are classified in four classes, normal tissue, benign lesion, in situ carcinoma and invasive carcinoma, and in two classes, carcinoma and non-carcinoma. The architecture of the network is designed to retrieve information at different scales, including both nuclei and overall tissue organization. This design allows the extension of the proposed system to whole-slide histology images. The features extracted by the CNN are also used for training a Support Vector Machine classifier. Accuracies of 77.8% for four class and 83.3% for carcinoma/non-carcinoma are achieved. The sensitivity of our method for cancer cases is 95.6%.

Biometrics refer to identity verification of individuals based on some physiologic or behavioural characteristics. The typical authentication process of a person consists in extracting a biometric pattern of him/her and matching it with the stored pattern for the authorised user obtaining a similarity value between patterns. In this work an efficient method for persons authentication is showed. The biometric pattern of the system is a set of feature points representing landmarks in the retinal vessel tree. The pattern extraction and matching is described. Also, a deep analysis of similarity metrics performance is presented for the biometric system. A database with samples of retina images from users on different moments of time is used, thus simulating a hard and real environment of verification. Even in this scenario, the system allows to establish a wide confidence band for the metric threshold where no errors are obtained for training and test sets.

The study of the retinal vasculature represents a fundamental stage in the screening and diagnosis of many high-incidence diseases, both systemic and ophthalmic. A complete retinal vascular analysis requires the segmentation of the vascular tree along with the classification of the blood vessels into arteries and veins. Early automatic methods approach these complementary segmentation and classification tasks in two sequential stages. However, currently, these two tasks are approached as a joint semantic segmentation, because the classification results highly depend on the effectiveness of the vessel segmentation. In that regard, we propose a novel approach for the simultaneous segmentation and classification of the retinal arteries and veins from eye fundus images. We propose a novel method that, unlike previous approaches, and thanks to the proposal of a novel loss, decomposes the joint task into three segmentation problems targeting arteries, veins and the whole vascular tree. This configuration allows to handle vessel crossings intuitively and directly provides accurate segmentation masks of the different target vascular trees. The provided ablation study on the public Retinal Images vessel Tree Extraction (RITE) dataset demonstrates that the proposed method provides a satisfactory performance, particularly in the segmentation of the different structures. Furthermore, the comparison with the state of the art shows that our method achieves highly competitive results in the artery/vein classification, while significantly improving the vascular segmentation. The proposed multi-segmentation method allows to detect more vessels and better segment the different structures, while achieving a competitive classification performance. Also, in these terms, our approach outperforms the approaches of various reference works. Moreover, in contrast with previous approaches, the proposed method allows to directly detect the vessel crossings, as well as preserving the continuity of both arteries and veins at these complex locations.

Diabetic retinopathy is an increasingly prevalent eye disorder that can lead to severe vision impairment. The severity grading of the disease using retinal images is key to provide an adequate treatment. However, in order to learn the diverse patterns and complex relations that are required for the grading, deep neural networks require very large annotated datasets that are not always available. This has been typically addressed by reusing networks that were pre-trained for natural image classification, hence relying on additional annotated data from a different domain. In contrast, we propose a novel pre-training approach that takes advantage of unlabeled multimodal visual data commonly available in ophthalmology. The use of multimodal visual data for pre-training purposes has been previously explored by training a network in the prediction of one image modality from another. However, that approach does not ensure a broad understanding of the retinal images, given that the network may exclusively focus on the similarities between modalities while ignoring the differences. Thus, we propose a novel self-supervised pre-training that explicitly teaches the networks to learn the common characteristics between modalities as well as the characteristics that are exclusive to the input modality. This provides a complete comprehension of the input domain and facilitates the training of downstream tasks that require a broad understanding of the retinal images, such as the grading of diabetic retinopathy. To validate and analyze the proposed approach, we performed an exhaustive experimentation on different public datasets. The transfer learning performance for the grading of diabetic retinopathy is evaluated under different settings while also comparing against previous state-of-the-art pre-training approaches. Additionally, a comparison against relevant state-of-the-art works for the detection and grading of diabetic retinopathy is also provided. The results show a satisfactory performance of the proposed approach, which outperforms previous pre-training alternatives in the grading of diabetic retinopathy.