Jonathan J. Magaña

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Academic Career Length

21Years (2006-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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10 June 2021 in Materials

Journal Article

Non-Ionic Surfactants for Stabilization of Polymeric Nanoparticles for Biomedical Uses

Hernán Cortés

Héctor Hernández Parra

Sergio Alberto Bernal Chávez

Maria Luisa Del Prado Audelo

Isaac Caballero

Gerardo Leyva Gómez

Surfactants are essential in the manufacture of polymeric nanoparticles by emulsion formation methods and to preserve the stability of carriers in liquid media. The deposition of non-ionic surfactants at the interface allows a considerable reduction of the globule of the emulsion with high biocompatibility and the possibility of oscillating the final sizes in a wide nanometric range. Therefore, this review presents an analysis of the three principal non-ionic surfactants utilized in the manufacture of polymeric nanoparticles; polysorbates, poly(vinyl alcohol), and poloxamers. We included a section on general properties and uses and a comprehensive compilation of formulations with each principal non-ionic surfactant. Then, we highlight a section on the interaction of non-ionic surfactants with biological barriers to emphasize that the function of surfactants is not limited to stabilizing the dispersion of nanoparticles and has a broad impact on pharmacokinetics. Finally, the last section corresponds to a recommendation in the experimental approach for choosing a surfactant applying the systematic methodology of Quality by Design.

9 July 2023 in Pharmaceutics

Journal Article

Films for Wound Healing Fabricated Using a Solvent Casting Technique

Fabiola Borbolla

Sheila Irais Peña-Corona

Sonia J. Farah

María Teresa Jiménez-Valdés

Emiliano Pineda

Gerardo Leyva Gómez

Wound healing is a complex process that involves restoring the structure of damaged tissues through four phases: hemostasis, inflammation, proliferation, and remodeling. Wound dressings are the most common treatment used to cover wounds, reduce infection risk and the loss of physiological fluids, and enhance wound healing. Despite there being several types of wound dressings based on different materials and fabricated through various techniques, polymeric films have been widely employed due to their biocompatibility and low immunogenicity. Furthermore, they are non-invasive, easy to apply, allow gas exchange, and can be transparent. Among different methods for designing polymeric films, solvent casting represents a reliable, preferable, and highly used technique due to its easygoing and relatively low-cost procedure compared to sophisticated methods such as spin coating, microfluidic spinning, or 3D printing. Therefore, this review focuses on the polymeric dressings obtained using this technique, emphasizing the critical manufacturing factors related to pharmaceuticals, specifically discussing the formulation variables necessary to create wound dressings that demonstrate effective performance.

13 August 2021 in Frontiers in Pharmacology

Journal Article

Therapeutic Applications of Terpenes on Inflammatory Diseases

Maria Luisa Del Prado Audelo

Hernán Cortés

Isaac H. Caballero-Florán

Maykel González-Torres

Lidia Escutia-Guadarrama

Gerardo Leyva Gómez

In the last decades, the search for natural products with biological applications as alternative treatments for several inflammatory diseases has increased. In this respect, terpenes are a family of organic compounds obtained mainly from plants and trees, such as tea, cannabis, thyme, and citrus fruits like lemon or mandarin. These molecules present attractive biological properties such as analgesic and anticonvulsant activities. Furthermore, several studies have demonstrated that certain terpenes could reduce inflammation symptoms by decreasing the release of pro-inflammatory cytokines for example, the nuclear transcription factor-kappa B, interleukin 1, and the tumor necrosis factor-alpha. Thus, due to various anti-inflammatory drugs provoking side effects, the search and analysis of novel therapeutics treatments are attractive. In this review, the analysis of terpenes’ chemical structure and their mechanisms in anti-inflammatory functions are addressed. Additionally, we present a general analysis of recent investigations about their applications as an alternative treatment for inflammatory diseases. Furthermore, we focus on terpenes-based nanoformulations and employed dosages to offer a global perspective of the state-of-the-art.

24 December 2021 in Frontiers in Environmental Science

Journal Article

Nanoremediation: Nanomaterials and Nanotechnologies for Environmental Cleanup

M. L. Del Prado-Audelo

I. García Kerdan

L. Escutia-Guadarrama

J. M. Reyna-González

Jonathan J. Magaña

Gerardo Leyva Gómez

Different global events such as industrial development and the population increment have triggered the presence and persistence of several organic and inorganic contaminants, representing a risk for the environment and human health. Consequently, the search and application of novel technologies for alleviating the challenge of environmental pollution are urgent. Nanotechnology is an emerging science that could be employed in different fields. In particular, Nanoremediation is a promising strategy defined as the engineered materials employed to clean up the environment, is an effective, rapid, and efficient technology to deal with persistent compounds such as pesticides, chlorinated solvents, halogenated chemicals, or heavy metals. Furthermore, nanoremediation is a sustainable alternative to eliminate emerging pollutants such as pharmaceutics or personal care products. Due to the variety of nanomaterials and their versatility, they could be employed in water, soil, or air media. This review provides an overview of the application of nanomaterials for media remediation. It analyzes the state of the art of different nanomaterials such as metal, carbon, polymer, and silica employed for water, soil, and air remediation.

15 December 2022 in Frontiers in Immunology

Journal Article

Immune system modulation in aging: Molecular mechanisms and therapeutic targets

Bulmaro Cisneros

Ian García-Aguirre

Juan Unzueta

Isabel Arrieta-Cruz

Oscar González-Morales

Jonathan J. Magaña

The function of the immune system declines during aging, compromising its response against pathogens, a phenomenon termed as “immunosenescence.” Alterations of the immune system undergone by aged individuals include thymic involution, defective memory T cells, impaired activation of naïve T cells, and weak memory response. Age-linked alterations of the innate immunity comprise perturbed chemotactic, phagocytic, and natural killing functions, as well as impaired antigen presentation. Overall, these alterations result in chronic low-grade inflammation (inflammaging) that negatively impacts health of elderly people. In this review, we address the most relevant molecules and mechanisms that regulate the relationship between immunosenescence and inflammaging and provide an updated description of the therapeutic strategies aimed to improve immunity in aged individuals.

1 July 2015 in Drug Discovery Today

Journal Article

Nanoparticle technology for treatment of Parkinson's disease: the role of surface phenomena in reaching the brain

Gerardo Leyva Gómez

Hernán Cortés

Jonathan J. Magaña

Norberto Leyva-García

David Quintanar

Benjamín Floran Garduño

About Me

Dr. Jonathan Javier Magaña-Aguirre obtained his Bachelor's Degree in Pharmacological Biologist Chemistry at the National Autonomous University of Mexico (UNAM) in 2002. He obtained an M.Sc. degree and Ph.D. degree in Genetics and Molecular Biology at CINVESTAV, México, in 2005 and 2008, respectively. He also has a diploma in Pharmaceutical administration. Immediately after obtaining his Ph.D., he entered as a researcher at the most important Reference Center for neuromuscular diseases in Mexico (National Rehabilitation Institute), where he quickly achieved his independence as a research group leader and was awarded the second highest ranking for Healthy Mexican researchers (Research in Medical Sciences level "E"). He belongs to the National Researchers Council as a Level 2 researcher (SNI 2) and is also a member of the Mexican Academy of Sciences. Also, he is a member of the steering committee of the Pan-American Hereditary Ataxia Network. From March 2020 to date, he has occupied the position of Head of the Bioengineering Department, Mexico City Region in Tecnológico de Monterrey. Finally, he has obtained multiple national and international awards, including "Esti¿mulo a las Investigaciones Me¿dicas Miguel Alema¿n Valde¿s" and "Premio de la Academia de Ciencias de Cuba".

Jonathan J. Magaña

Jonathan J. Magaña

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