Lung cancer (LC) is the leading cause of cancer-related deaths, responsible for approximately 18.4% of all cancer mortalities in both sexes combined. The use of systemic therapeutics remains one of the primary treatments for LC. However, the therapeutic efficacy of these agents is limited due to their associated severe adverse effects, systemic toxicity and poor selectivity. In contrast, pulmonary delivery of anticancer drugs can provide many advantages over conventional routes. The inhalation route allows the direct delivery of chemotherapeutic agents to the target LC cells with high local concertation that may enhance the antitumor activity and lead to lower dosing and fewer systemic toxicities. Nevertheless, this route faces by many physiological barriers and technological challenges that may significantly affect the lung deposition, retention, and efficacy of anticancer drugs. The use of lipid-based nanocarriers could potentially overcome these problems owing to their unique characteristics, such as the ability to entrap drugs with various physicochemical properties, and their enhanced permeability and retention (EPR) effect for passive targeting. Besides, they can be functionalized with different targeting moieties for active targeting. This article highlights the physiological, physicochemical, and technological considerations for efficient inhalable anticancer delivery using lipid-based nanocarriers and their cutting-edge role in LC treatment.

The water crisis is identified as the most serious global risk for the coming decade. Distilled water is one of the on-demand elements in academic laboratories; however, water scarcity may eventually affect the education sector, necessitating the implementation of new policies. Human behavior, awareness, knowledge, and opinion is having an impact on water management; accordingly, a questionnaire was purposely designed and validated to assess these variables in a Malaysian public university regarding the use of non-distilled water produced by the distillation process. An exploratory factor analysis yielded four factors: “concept of green laboratory and water”, “usage of non-distilled water”, “knowledge about water distillation”, and “behavior related to water conservation”. Using the Mann–Whitney U test to compare laboratory and non-laboratory users’ responses, the variables “Knowledge”, “Behavior”, and “Opinion” revealed statistically significant differences, with laboratory users scoring higher in all four variables. Employing the Kruskal–Wallis H test in an occupation-based comparison among laboratory users, and with an additional variable “Practice”, showed that “Lecturer” has the highest mean rank for “Awareness”, “Behavior”, and “Opinion”, while “Laboratory Assistant” has the highest mean rank for “Knowledge”. This study provides a rationale analysis for future insights to educate faculty members about the reuse of non-distilled water sustainably.