Caffeic acid phenethyl ester (CAPE) is a strong antioxidant extracted from honey bee-hive propolis. The mentioned compound, a well-known NF-κB inhibitor, has been used in traditional medicine as a potent anti-inflammatory agent. CAPE has a broad spectrum of biological properties including anti-viral, anti-bacterial, anti-cancer, immunomodulatory, and wound-healing activities. This review characterizes published data about CAPE biological properties and potential therapeutic applications, that can be used in various diseases.

The sebaceous glands are responsible for the secretion of sebum. Its function is to maintain a proper epidermal barrier and participate in metabolic processes within the epidermis. Excessive sebum secretion leads to the development of various seborrheic diseases. The aim of this study was to determine the in vivo correlation between the amount of sebum and the directional reflectance of the skin. Measurements were performed using a Sebumeter (Courage + Khazaka, Germany) and a directional hemispherical reflectometer (Solar 410, SOC, USA). It has been shown that the amount of sebum does not affect the directional reflectance of the skin at a wavelength of 335–380 nm. With an increase in the amount of sebum, the directional reflectance of the skin decreases at wavelengths of 400–540 nm and 480–600 nm. However, with an increase in the amount of sebum, the directional reflectance of the skin increases at wavelengths of 590–720 nm, 700–1100 nm, 1000–1700 nm, and 1700–2500 nm. The closest relationship between amount of sebum and directional reflectance of the skin was observed at a wavelength of 700–1100 nm. Reflecting/scattering radiation from the skin surface, depending on the sebum content, may be clinically significant not only in the context of exposure to solar radiation but also in the context of numerous therapeutic methods based on artificial sources of radiation. In this area, it is desirable for the radiation to penetrate the skin as effectively as possible. The obtained preliminary results confirm that the used method is an interesting alternative to spectroscopic methods.

Background: Acne scars significantly impact skin texture and esthetics, necessitating effective treatment modalities. This study evaluates the efficacy of erbium glass laser therapy in improving atrophic acne scars using advanced image analysis techniques. Materials and methods: Twenty patients with mild to moderate atrophic scars underwent two sessions of 1550 nm erbium glass laser treatment. The clinical photographs were analyzed using a Gray-Level Co-occurrence Matrix (GLCM) to assess changes in contrast and homogeneity across the grayscale and RGB channels. The analysis revealed statistically significant improvements post-therapy, including reduced contrast and increased homogeneity, indicating a smoother and more uniform skin texture. The blue and green channels demonstrated the greatest sensitivity to surface-level textural changes, while the red channel exhibited the smallest differences, reflecting its deeper penetration and reduced sensitivity to surface alterations. Conclusions: These findings underscore the value of quantitative imaging techniques in dermatology for objectively evaluating therapeutic outcomes and optimizing treatment strategies. Erbium glass laser therapy emerges as a non-invasive and effective solution for acne scar management.

The harmful effects of solar radiation on the skin are known and scientifically proven, with recent studies indicating that not only ultraviolet (UV) radiation but also infrared (IR) radiation contributes to skin photoaging and increases the risk of carcinogenesis. Infrared radiation is also responsible for the degradation of protective carotenoids in the skin, the disruption of calcium homeostasis, and the activation of apoptosis pathways. The biological mechanisms underlying these effects include an increased level of reactive oxygen species and increased expression of metalloproteinases in the skin. The aim of this study was to evaluate the photoprotective properties of 10 cold-pressed plant oils in the infrared spectral range from 1000 nm to 2500 nm by assessing their impact on the directional–hemispherical reflectance (DHR) of human skin after their topical application. This study was conducted in vivo on the skin of 12 volunteers, with non-invasive DHR measurements taken before and directly after the application of the oil and 30 min later. Additionally, the correlation between the oil’s compounds (chlorophyll a, chlorophyll b, lycopene, and β-carotene) and antioxidant activity, expressed as the DPPH free radical scavenging capacity, was analyzed in relation to the differences in the skin’s DHR observed. An interesting result was obtained in the context of protecting the skin against IR radiation. A statistically significant increase in the skin’s reflectance after the penetration of the oil (p < 0.05) was observed in the 1700–2500 nm range for the chokeberry, fig, pomegranate, and perilla oils, suggesting their potential as photoprotective agents against IR. These findings indicate that chokeberry, fig, pomegranate, and perilla oils may serve as ingredients in cosmetic formulations designed for broad-spectrum skin photoprotection, complementing traditional UV filters with additional protection against infrared radiation. However, further research is needed to confirm these findings in a larger population.

The growing popularity of permanent makeup is associated with an increase in the need for treatments that effectively remove pigments from the skin. The risk of the radiation wavelength not being adjusted to the spectral ranges of individual pigments that compose the final color appears because complex dye compositions are used for permanent makeup. Incorrectly selected laser parameters may reduce the effectiveness of the treatment and increase the risk of thermal damage, leading to scarring and discoloration. The aim of the study was to evaluate the effectiveness of laser permanent makeup removal using hyperspectral imaging. Five different dyes were implemented into the skin of the pig’s ear. Then the dyes were removed using a Q-switched Nd:YAG laser. During the study, skin measurements were performed with a hyperspectral camera before and after laser application. The results were analyzed using GLCM, reflectance, and quadratic tree decomposition. Based on the obtained results, it was found that the most difficult dye to remove is white because it is characterized by high reflectivity of electromagnetic radiation. After the dye removal, there was a decrease in reflectance and contrast of GLCM and an increase in homogeneity for all dyes except for white. After the laser application, the pigments were distributed more equally in the skin.