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Zinc oxide-ternary heterostructure Mn3O4/ZnO/Eu2O3 nanocomposites were successfully prepared via waste curd as fuel by a facile one-pot combustion procedure. The fabricated heterostructures were characterized utilizing XRD, UV–Visible, FT-IR, FE-SEM, HRTEM and EDX analysis. The photocatalytic degradation efficacy of the synthesized ternary nanocomposite was evaluated utilizing model organic pollutants of methylene blue (MB) and methyl orange (MO) in water as examples of cationic dyes and anionic dyes, respectively, under natural solar irradiation. The effect of various experimental factors, viz. the effect of a light source, catalyst dosage, irradiation time, pH of dye solution and dye concentration on the photodegradation activity, was systematically studied. The ternary Mn3O4/ZnO/Eu2O3 photocatalyst exhibited excellent MB and MO degradation activity of 98% and 96%, respectively, at 150 min under natural sunlight irradiation. Experiments further conclude that the fabricated nanocomposite exhibits pH-dependent photocatalytic efficacy, and for best results, concentrations of dye and catalysts have to be maintained in a specific range. The prepared photocatalysts are exemplary and could be employed for wastewater handling and several ecological applications.
Jayachamarajapura Shubha; Haralahalli Savitha; Syed Adil; Mujeeb Khan; Mohammad Hatshan; Kiran Kavalli; Baji Shaik. Straightforward Synthesis of Mn3O4/ZnO/Eu2O3-Based Ternary Heterostructure Nano-Photocatalyst and Its Application for the Photodegradation of Methyl Orange and Methylene Blue Dyes. Molecules 2021, 26, 4661 .
AMA StyleJayachamarajapura Shubha, Haralahalli Savitha, Syed Adil, Mujeeb Khan, Mohammad Hatshan, Kiran Kavalli, Baji Shaik. Straightforward Synthesis of Mn3O4/ZnO/Eu2O3-Based Ternary Heterostructure Nano-Photocatalyst and Its Application for the Photodegradation of Methyl Orange and Methylene Blue Dyes. Molecules. 2021; 26 (15):4661.
Chicago/Turabian StyleJayachamarajapura Shubha; Haralahalli Savitha; Syed Adil; Mujeeb Khan; Mohammad Hatshan; Kiran Kavalli; Baji Shaik. 2021. "Straightforward Synthesis of Mn3O4/ZnO/Eu2O3-Based Ternary Heterostructure Nano-Photocatalyst and Its Application for the Photodegradation of Methyl Orange and Methylene Blue Dyes." Molecules 26, no. 15: 4661.
Catalytic efficacy of metal-based catalysts can be significantly enhanced by doping graphene or its derivatives in the catalytic protocol. In continuation of previous work regarding the catalytic properties of highly-reduced graphene oxide (HRG), graphene-oxide (GO) doped mixed metal oxide-based nanocomposites, herein we report a simple, straightforward and solventless mechanochemical preparation of N-doped graphene (NDG)/mixed metal oxide-based nanocomposites of ZnO–MnCO3 (i.e., ZnO–MnCO3/(X%-NDG)), wherein N-doped graphene (NDG) is employed as a dopant. The nanocomposites were prepared by physical milling of separately fabricated NDG and ZnO–MnCO3 calcined at 300 °C through eco-friendly ball mill procedure. The as-obtained samples were characterized via X-ray diffraction (XRD), Thermogravimetric analysis (TGA), Fourier-transform infrared spectroscopy (FT-IR), Raman, Field emission scanning electron microscopy (FESEM), Energy-dispersive X-ray spectroscopy (EDX) and surface area analysis techniques. To explore the effectiveness of the obtained materials, liquid-phase dehydrogenation of benzyl alcohol (BOH) to benzaldehyde (BH) was chosen as a benchmark reaction using eco-friendly oxidant (O2) without adding any harmful surfactants or additives. During the systematic investigation of reaction, it was revealed that the ZnO–MnCO3/NDG catalyst exhibited very distinct specific-activity (80 mmol/h.g) with a 100% BOH conversion and <99% selectivity towards BH in a very short time. The mechanochemically synthesized NDG-based nanocomposite showed remarkable enhancement in the catalytic performance and increased surface area compared with the catalyst without graphene (i.e., ZnO–MnCO3). Under the optimum catalytic conditions, the catalyst successfully transformed various aromatic, heterocyclic, allylic, primary, secondary and aliphatic alcohols to their respective ketones and aldehydes with high selectively and convertibility without over-oxidation to acids. In addition, the ZnO–MnCO3/NDG was also recycled up to six times with no apparent loss in its efficacy.
Mujeeb Khan; Syed Adil; Mohamed Assal; Abdulrahman Alharthi; Mohammed Shaik; Mufsir Kuniyil; Abdulrahman Al-Warthan; Aslam Khan; Zeeshan Nawaz; Hamid Shaikh; Mohammed Siddiqui. Solventless Mechanochemical Fabrication of ZnO–MnCO3/N-Doped Graphene Nanocomposite: Efficacious and Recoverable Catalyst for Selective Aerobic Dehydrogenation of Alcohols under Alkali-Free Conditions. Catalysts 2021, 11, 760 .
AMA StyleMujeeb Khan, Syed Adil, Mohamed Assal, Abdulrahman Alharthi, Mohammed Shaik, Mufsir Kuniyil, Abdulrahman Al-Warthan, Aslam Khan, Zeeshan Nawaz, Hamid Shaikh, Mohammed Siddiqui. Solventless Mechanochemical Fabrication of ZnO–MnCO3/N-Doped Graphene Nanocomposite: Efficacious and Recoverable Catalyst for Selective Aerobic Dehydrogenation of Alcohols under Alkali-Free Conditions. Catalysts. 2021; 11 (7):760.
Chicago/Turabian StyleMujeeb Khan; Syed Adil; Mohamed Assal; Abdulrahman Alharthi; Mohammed Shaik; Mufsir Kuniyil; Abdulrahman Al-Warthan; Aslam Khan; Zeeshan Nawaz; Hamid Shaikh; Mohammed Siddiqui. 2021. "Solventless Mechanochemical Fabrication of ZnO–MnCO3/N-Doped Graphene Nanocomposite: Efficacious and Recoverable Catalyst for Selective Aerobic Dehydrogenation of Alcohols under Alkali-Free Conditions." Catalysts 11, no. 7: 760.
Biofilms not only protect bacteria and Candida species from antibiotics, but they also promote the emergence of drug-resistant strains, making eradication more challenging. As a result, novel antimicrobial agents to counteract biofilm formation are desperately needed. In this study, Terminalia catappa leaf extract (TCE) was used to optimize the TCE-capped silver nanoparticles (TCE-AgNPs) via a one-pot single-step method. Varied concentrations of TCE have yielded different sized AgNPs. The physico-chemical characterization of TCE-AgNPs using UV-Vis, SEM, TEM, FTIR, and Raman spectroscopy have confirmed the formation of nanostructures, their shape and size and plausible role of TCE bio-active compounds, most likely involved in the synthesis as well as stabilization of NPs, respectively. TCE-AgNPs have been tested for antibiofilm and antimicrobial activity against multidrug-resistant Pseudomonas aeruginosa (MDR-PA), methicillin-resistant Staphylococcus aureus (MRSA), and Candida albicans using various microbiological protocols. TCE-Ag-NPs−3 significantly inhibits biofilm formation of MDR-PA, MRSA, and C. albicans by 73.7, 69.56, and 63.63%, respectively, at a concentration of 7.8 µg/mL, as determined by crystal violet microtiter assay. Furthermore, SEM micrograph shows that TCE-AgNPs significantly inhibit the colonization and adherence of biofilm forming cells; individual cells with loss of cell wall and membrane integrity were also observed, suggesting that the biofilm architecture and EPS matrix were severely damaged. Moreover, TEM and SEM images showed that TCE-AgNPs brutally damaged the cell wall and membranes of MDR-PA, MRSA, and C. albicans. Additionally, extreme ultrastructural changes such as deformation, disintegration, and separation of cell wall and membrane from the cells, have also been observed, indicating significant loss of membrane and cell wall integrity, which eventually led to cell death. Overall, the research revealed a simple, environmentally friendly, and low-cost method for producing colloidal TCE-AgNPs with promising applications in advanced clinical settings against broad-spectrum biofilm-forming antibiotic-resistant bacteria and candida strains.
Mohammad Ansari; Abul Kalam; Abdullah Al-Sehemi; Mohammad Alomary; Sami AlYahya; Mohammad Aziz; Shekhar Srivastava; Saad Alghamdi; Sultan Akhtar; Hussain Almalki; Syed Adil; Mujeeb Khan; Mohammad Hatshan. Counteraction of Biofilm Formation and Antimicrobial Potential of Terminalia catappa Functionalized Silver Nanoparticles against Candida albicans and Multidrug-Resistant Gram-Negative and Gram-Positive Bacteria. Antibiotics 2021, 10, 725 .
AMA StyleMohammad Ansari, Abul Kalam, Abdullah Al-Sehemi, Mohammad Alomary, Sami AlYahya, Mohammad Aziz, Shekhar Srivastava, Saad Alghamdi, Sultan Akhtar, Hussain Almalki, Syed Adil, Mujeeb Khan, Mohammad Hatshan. Counteraction of Biofilm Formation and Antimicrobial Potential of Terminalia catappa Functionalized Silver Nanoparticles against Candida albicans and Multidrug-Resistant Gram-Negative and Gram-Positive Bacteria. Antibiotics. 2021; 10 (6):725.
Chicago/Turabian StyleMohammad Ansari; Abul Kalam; Abdullah Al-Sehemi; Mohammad Alomary; Sami AlYahya; Mohammad Aziz; Shekhar Srivastava; Saad Alghamdi; Sultan Akhtar; Hussain Almalki; Syed Adil; Mujeeb Khan; Mohammad Hatshan. 2021. "Counteraction of Biofilm Formation and Antimicrobial Potential of Terminalia catappa Functionalized Silver Nanoparticles against Candida albicans and Multidrug-Resistant Gram-Negative and Gram-Positive Bacteria." Antibiotics 10, no. 6: 725.
Graphene nanocomposites have gained significant interest in a variety of biological applications due to their unique properties. Herein, we have studied the apoptosis-inducing ability and anticancer properties of functionalized highly reduced graphene oxide (HRG) and gold nanoparticles (Au NPs)-based nanocomposites (AP-HRG-Au). Samples were prepared under facile conditions via simple stirring and ultrasonication. All the samples were tested for their anticancer properties against different human cancer cell lines including lung (A549), liver (HepG2), and breast (MCF-7) cancer cells using doxorubicin as a positive control. In order to enhance the solubility and bioavailability of the sample, HRG was functionalized with 1-aminopyrene (1-AP) as a stabilizing ligand. The ligand also facilitated the homogeneous growth of Au NPs on the surface of HRG by offering chemically specific binding sites. The synthesis of nanocomposites and the surface functionalization of HRG were confirmed by UV–Vis, powder X-ray diffraction, and Fourier transform infrared spectroscopy. The structure and morphology of the as-prepared nanocomposites were established by high-resolution transmission electron microscopy. Because of the functionalization, the AP-HRG-Au nanocomposite exhibited enhanced physical stability and high dispersibility. A comparative anticancer study of pristine HRG, nonfunctionalized HRG-Au, and 1-AP-functionalized AP-HRG-Au nanocomposites revealed the enhanced apoptosis ability of functionalized nanocomposites compared to the nonfunctionalized sample, whereas the pristine HRG did not show any anticancer ability against all tested cell lines. Both HRG-Au and AP-HRG-Au have induced a concentration-dependent reduction in cell viability in all tested cell lines after 48 h of exposure, with a significantly higher response in MCF-7 cells compared to the remaining cells. Therefore, MCF-7 cells were selected to perform detailed investigations using apoptosis assay, cell cycle analysis, and reactive oxygen species measurements. These results suggest that AP-HRG-Au induces enhanced apoptosis in human breast cancer cells.
Syed Farooq Adil; Mohammed Rafi Shaik; Fahd A. Nasr; Ali S. Alqahtani; Mohammad Z. Ahmed; Wajhul Qamar; Mufsir Kuniyil; Adibah Almutairi; Abdulrahman Alwarthan; Mohammed Rafiq H. Siddiqui; Mohammad Rafe Hatshan; Mujeeb Khan. Enhanced Apoptosis by Functionalized Highly Reduced Graphene Oxide and Gold Nanocomposites in MCF-7 Breast Cancer Cells. ACS Omega 2021, 6, 15147 -15155.
AMA StyleSyed Farooq Adil, Mohammed Rafi Shaik, Fahd A. Nasr, Ali S. Alqahtani, Mohammad Z. Ahmed, Wajhul Qamar, Mufsir Kuniyil, Adibah Almutairi, Abdulrahman Alwarthan, Mohammed Rafiq H. Siddiqui, Mohammad Rafe Hatshan, Mujeeb Khan. Enhanced Apoptosis by Functionalized Highly Reduced Graphene Oxide and Gold Nanocomposites in MCF-7 Breast Cancer Cells. ACS Omega. 2021; 6 (23):15147-15155.
Chicago/Turabian StyleSyed Farooq Adil; Mohammed Rafi Shaik; Fahd A. Nasr; Ali S. Alqahtani; Mohammad Z. Ahmed; Wajhul Qamar; Mufsir Kuniyil; Adibah Almutairi; Abdulrahman Alwarthan; Mohammed Rafiq H. Siddiqui; Mohammad Rafe Hatshan; Mujeeb Khan. 2021. "Enhanced Apoptosis by Functionalized Highly Reduced Graphene Oxide and Gold Nanocomposites in MCF-7 Breast Cancer Cells." ACS Omega 6, no. 23: 15147-15155.
Palladium-based carbon catalysts (Pd/C) can be potentially applied as an efficient catalyst for Suzuki–Miyaura and Mizoroki–Heck coupling reactions. Herein, a variety of catalysts of palladium on activated carbon were prepared by varying the content of ‘Pd’ via an in situ reduction method, using hydrogen as a reducing agent. The as-prepared catalysts (0.5 wt % Pd/C, 1 wt % Pd/C, 2 wt % Pd/C and 3 wt % Pd/C) were characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX) and Brunauer–Emmett–Teller (BET) analyses. The catalysts were tested as a coupling catalyst for Suzuki–Miyaura coupling reactions involving aryl halides and phenyl boronic acid. The optimization of the catalyst by varying the palladium content on the activated carbon yielded Pd/C catalysts with very high catalytic activity for Suzuki reactions of aryl halides and a Mizoroki–Heck cross-coupling reaction of 4-bromoanisol and acrylic acid in an aqueous medium. A high ‘Pd’ content and uniform ‘Pd’ impregnation significantly affected the activity of the catalysts. The catalytic activity of 3% Pd/C was found to make it a more efficient catalyst when compared with the other synthesized Pd/C catalysts. Furthermore, the catalyst reusability was also tested for Suzuki reactions by repeatedly performing the same reaction using the recovered catalyst. The 3% Pd/C catalyst displayed better reusability even after several reactions.
Hamed Alshammari; Obaid Aldosari; Mohammad Alotaibi; Raja Alotaibi; Mosaed Alhumaimess; Moataz Morad; Syed Adil; Mohammed Shaik; Mohammad Islam; Mujeeb Khan; Abdulrahman Alwarthan. Facile Synthesis and Characterization of [email protected] Catalyst for the Suzuki-Miyaura and Mizoroki-Heck Coupling Reactions. Applied Sciences 2021, 11, 4822 .
AMA StyleHamed Alshammari, Obaid Aldosari, Mohammad Alotaibi, Raja Alotaibi, Mosaed Alhumaimess, Moataz Morad, Syed Adil, Mohammed Shaik, Mohammad Islam, Mujeeb Khan, Abdulrahman Alwarthan. Facile Synthesis and Characterization of [email protected] Catalyst for the Suzuki-Miyaura and Mizoroki-Heck Coupling Reactions. Applied Sciences. 2021; 11 (11):4822.
Chicago/Turabian StyleHamed Alshammari; Obaid Aldosari; Mohammad Alotaibi; Raja Alotaibi; Mosaed Alhumaimess; Moataz Morad; Syed Adil; Mohammed Shaik; Mohammad Islam; Mujeeb Khan; Abdulrahman Alwarthan. 2021. "Facile Synthesis and Characterization of [email protected] Catalyst for the Suzuki-Miyaura and Mizoroki-Heck Coupling Reactions." Applied Sciences 11, no. 11: 4822.
A simple and efficient BF3-OEt2 promoted C3-alkylation of indole has been developed to obtain3-indolylsuccinimidesfrom commercially available indoles and maleimides, with excellent yields under mild reaction conditions. Furthermore, anti-proliferative activity of these conjugates was evaluated against HT-29 (Colorectal), Hepg2 (Liver) and A549 (Lung) human cancer cell lines. One of the compounds, 3w, having N,N-Dimethylatedindolylsuccinimide is a potent congener amongst the series with IC50 value 0.02 µM and 0.8 µM against HT-29 and Hepg2 cell lines, respectively, and compound 3i was most active amongst the series with IC50 value 1.5 µM against A549 cells. Molecular docking study and mechanism of reaction have briefly beendiscussed. This method is better than previous reports in view of yield and substrate scope including electron deficient indoles.
Iqbal Shaikh; Abdul Rahim; Shaikh Faazil; Syed Adil; Mohamed Assal; Mohammad Hatshan. BF3-OEt2 Catalyzed C3-Alkylation of Indole: Synthesis of Indolylsuccinimidesand Their Cytotoxicity Studies. Molecules 2021, 26, 2202 .
AMA StyleIqbal Shaikh, Abdul Rahim, Shaikh Faazil, Syed Adil, Mohamed Assal, Mohammad Hatshan. BF3-OEt2 Catalyzed C3-Alkylation of Indole: Synthesis of Indolylsuccinimidesand Their Cytotoxicity Studies. Molecules. 2021; 26 (8):2202.
Chicago/Turabian StyleIqbal Shaikh; Abdul Rahim; Shaikh Faazil; Syed Adil; Mohamed Assal; Mohammad Hatshan. 2021. "BF3-OEt2 Catalyzed C3-Alkylation of Indole: Synthesis of Indolylsuccinimidesand Their Cytotoxicity Studies." Molecules 26, no. 8: 2202.
The mixed metal oxides Bi2MoO6 and La-doped Bi2MoO6 were prepared by the sol–gel method. Then, varying quantities of the as-prepared mixed metal oxides were blended with graphene oxide (GO), employing sonication, to obtain Bi2MoO6 /GO (BM/GO) and La-Bi2MoO6 /GO (LBM/GO) nanocomposites. These prepared materials were characterized by different techniques such as thermal gravimetric analysis (TGA), X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET), X-ray photoelectron spectroscopy (XPS), scanning electron microscope (SEM), and transmission electron microscopy (TEM). Dielectric properties were studied by using a precision impedance analyzer. Dielectric constant and loss tan of the synthesized composites were studied as a function of frequency by using a precision impedance analyzer. Overall, the dielectric constant (ɛ’) observed for the LBM/GO composites was higher than that of BM/GO.
Syed Adil; Shoomaila Latif; Muhammad Waqar; Muhammad Imran; Sadia Noreen; Mujeeb Khan; Mohammed Shaik; Mohammad Hatshan. Dielectric Studies of Bi2MoO6/Graphene Oxide and La-Doped Bi2MoO6/Graphene Oxide Nanocomposites. Metals 2021, 11, 559 .
AMA StyleSyed Adil, Shoomaila Latif, Muhammad Waqar, Muhammad Imran, Sadia Noreen, Mujeeb Khan, Mohammed Shaik, Mohammad Hatshan. Dielectric Studies of Bi2MoO6/Graphene Oxide and La-Doped Bi2MoO6/Graphene Oxide Nanocomposites. Metals. 2021; 11 (4):559.
Chicago/Turabian StyleSyed Adil; Shoomaila Latif; Muhammad Waqar; Muhammad Imran; Sadia Noreen; Mujeeb Khan; Mohammed Shaik; Mohammad Hatshan. 2021. "Dielectric Studies of Bi2MoO6/Graphene Oxide and La-Doped Bi2MoO6/Graphene Oxide Nanocomposites." Metals 11, no. 4: 559.
In the present study, a simple and eco-friendly route for the synthesis of copper oxide nanoparticles (CuO NPs) using leaf extract of Phyllanthus emblica as fuel has been demonstrated, as P. emblica is a locally available abundant plant. The formation of the as-prepared CuO NPs was confirmed by using various techniques, such as UV–Vis absorption spectroscopy, cold field scanning electron microscopy (CF–SEM), energy dispersive X-ray analysis (EDX), dynamic light scattering (DLS), and X-ray photoelectron (XPS). The hydrodynamic size of the CuO NPs was found to be 80 nm, while the zeta potential of -28.6 mV was obtained. The elemental composition was confirmed by EDX analysis accompanied with elemental mapping, while the crystalline nature was substantiated by the XRD diffractogram. The as-synthesized CuO NPs were studied for their use as an adsorbent material for the removal of As(V) from water. It was confirmed that the CuO NPs effectively removed As(V) via adsorption, and the adsorption efficiency was found to be best at a higher pH. The maximum adsorption capacity of CuO for As(V) was found to be 1.17 mg/g calculated using the Langmuir equation.
Sadia Saif; Syed Adil; Mujeeb Khan; Mohammad Hatshan; Merajuddin Khan; Farzana Bashir. Adsorption Studies of Arsenic(V) by CuO Nanoparticles Synthesized by Phyllanthus emblica Leaf-Extract-Fueled Solution Combustion Synthesis. Sustainability 2021, 13, 2017 .
AMA StyleSadia Saif, Syed Adil, Mujeeb Khan, Mohammad Hatshan, Merajuddin Khan, Farzana Bashir. Adsorption Studies of Arsenic(V) by CuO Nanoparticles Synthesized by Phyllanthus emblica Leaf-Extract-Fueled Solution Combustion Synthesis. Sustainability. 2021; 13 (4):2017.
Chicago/Turabian StyleSadia Saif; Syed Adil; Mujeeb Khan; Mohammad Hatshan; Merajuddin Khan; Farzana Bashir. 2021. "Adsorption Studies of Arsenic(V) by CuO Nanoparticles Synthesized by Phyllanthus emblica Leaf-Extract-Fueled Solution Combustion Synthesis." Sustainability 13, no. 4: 2017.
Nanoparticles (NPs) prepared through safer, eco-friendly and natural-based products can be used various applications including antimicrobial and biomedical applications. Quorum sensing (QS) is a complex system for intercellular communication that regulates the expression of many virulence determinants, in the opportunistic Pseudomonas aeruginosa. Thus, the disruption of QS-mediated communication system could be an alternative strategy to combat infection caused by drug resistant P. aeruginosa. In this study, zinc oxide nanoparticles (ZnO NPs) were synthesized by using seed extract of Butea monosperma and further characterized by XRD, SEM and TEM. The biosynthesized ZnO NPs were then subjected to the investigation of their antibacterial, antibiofilm activities as well as the anti-quorum sensing potentialities for biomedical applications. The minimum inhibitory concentration (MIC) value against P. aeruginosa was found 1600 µg/ml, and it was found that ZnO NPs effectively reduced virulence factors Viz. swarming and swimming of P. aeruginosa by 62.8 and 45%, respectively. Exopolysaccharides production was also affected by ZnO NPs which indicate the disruption of biofilm formation. Further, the in silico docking analysis displayed that ZnO NPs efficiently interacted within QS (Las/Rhl) mechanism of P. aeruginosa by binding to the catalytic cleft of LasI synthase (Gly-116-ZnO = 2.8 Å), RhlI synthase (Gly-180-ZnO = 3.7 Å) and transcription receptor protein LasR receptor (Asn-141-ZnO = 2.9 Å), RhlR receptor (Tyr-72-ZnO = 2.6 Å). Thus, it was concluded that the effective interaction of ZnO NPs with Las and Rhl system led to the inactivation of autoinducers such as N-acyl homoserine lactones (AHL) molecules which finally led to the inactivation of QS and down regulation of virulence determinants. Consequently, the present in vitro and in silico results obtained suggest that the synthesized ZnO NPs can be efficiently used as potent antimicrobial agents to prevent the colonization, biofilm formation as well as anti-QS-mediated determinants caused by pathogenic drug resistant bacteria.
Syed Ghazanfar Ali; Mohammad Azam Ansari; Qazi Mohammad Sajid Jamal; Ahmad Almatroudi; Mohammad A. Alzohairy; Mohammad N. Alomary; Suriya Rehman; Murali Mahadevamurthy; Mohammad Jalal; Haris M. Khan; Syed Farooq Adil; Mujeeb Khan; Abdulrahman Al-Warthan. Butea monosperma seed extract mediated biosynthesis of ZnO NPs and their antibacterial, antibiofilm and anti-quorum sensing potentialities. Arabian Journal of Chemistry 2021, 14, 103044 .
AMA StyleSyed Ghazanfar Ali, Mohammad Azam Ansari, Qazi Mohammad Sajid Jamal, Ahmad Almatroudi, Mohammad A. Alzohairy, Mohammad N. Alomary, Suriya Rehman, Murali Mahadevamurthy, Mohammad Jalal, Haris M. Khan, Syed Farooq Adil, Mujeeb Khan, Abdulrahman Al-Warthan. Butea monosperma seed extract mediated biosynthesis of ZnO NPs and their antibacterial, antibiofilm and anti-quorum sensing potentialities. Arabian Journal of Chemistry. 2021; 14 (4):103044.
Chicago/Turabian StyleSyed Ghazanfar Ali; Mohammad Azam Ansari; Qazi Mohammad Sajid Jamal; Ahmad Almatroudi; Mohammad A. Alzohairy; Mohammad N. Alomary; Suriya Rehman; Murali Mahadevamurthy; Mohammad Jalal; Haris M. Khan; Syed Farooq Adil; Mujeeb Khan; Abdulrahman Al-Warthan. 2021. "Butea monosperma seed extract mediated biosynthesis of ZnO NPs and their antibacterial, antibiofilm and anti-quorum sensing potentialities." Arabian Journal of Chemistry 14, no. 4: 103044.
The ZnO-based ternary heterostructure ZnO/Eu2O3/NiO nanoparticles are synthesized using waste curd as fuel by a simple one-pot combustion method. The as-synthesized heterostructure is characterized by using various spectroscopic and microscopic techniques including X-ray diffraction, UV–vis, FTIR, SEM, and TEM analyses. The photocatalytic activity of the ternary nanocomposite was tested for the photodegradation of methylene blue (MB) under solar light irradiation. The results have revealed that the ternary ZnO/Eu2O3/NiO photocatalyst exhibits excellent performance toward the photocatalytic degradation of the studied dye. Optimization studies revealed that the synthesized heterostructure exhibited a pH-dependent photocatalytic activity, and better results are obtained for specific concentrations of dye and catalysts. Among the different light sources employed during the study, the catalyst was found to possess the best degradation efficiency in visible light.
J. Pranesh Shubha; Syed F. Adil; Mujeeb Khan; Mohammad R. Hatshan; Aslam Khan. Facile Fabrication of a ZnO/Eu2O3/NiO-Based Ternary Heterostructure Nanophotocatalyst and Its Application for the Degradation of Methylene Blue. ACS Omega 2021, 6, 3866 -3874.
AMA StyleJ. Pranesh Shubha, Syed F. Adil, Mujeeb Khan, Mohammad R. Hatshan, Aslam Khan. Facile Fabrication of a ZnO/Eu2O3/NiO-Based Ternary Heterostructure Nanophotocatalyst and Its Application for the Degradation of Methylene Blue. ACS Omega. 2021; 6 (5):3866-3874.
Chicago/Turabian StyleJ. Pranesh Shubha; Syed F. Adil; Mujeeb Khan; Mohammad R. Hatshan; Aslam Khan. 2021. "Facile Fabrication of a ZnO/Eu2O3/NiO-Based Ternary Heterostructure Nanophotocatalyst and Its Application for the Degradation of Methylene Blue." ACS Omega 6, no. 5: 3866-3874.
Degradation of organic dyes and their byproducts by heterogeneous photocatalysts is an essential process, as these dyes can be potentially discharged in wastewater and threaten aquatic and xerophyte life. Therefore, their complete mineralization into nontoxic components (water and salt) is necessary through the process of heterogeneous photocatalysis. In this study, Zr/CrO2 (Zirconium-doped chromium IV oxide) nanocomposite-based photocatalysts with different compositions (1, 3, 5, 7 & 9 wt.%) were prepared by an environmentally friendly, solid-state reaction at room temperature. The as-prepared samples were calcined under air at 450 °C in a furnace for a specific period of time. The synthesis of Zr/CrO2 photocatalysts was confirmed by various techniques, including XRD, SEM, EDX, FT-IR, UV-Vis, and BET. The photocatalytic properties of all samples were tested towards the degradation of methylene blue and methyl orange organic dyes under UV light. The results revealed a concentration-dependent photocatalytic activity of photocatalysts, which increased the amount of dopant (up to 5 wt.%). However, the degradation efficiency of the catalysts decreased upon further increasing the amount of dopant due to the recombination of holes and photoexcited electrons.
Zahir Muhammad; Farman Ali; Muhammad Sajjad; Nisar Ali; Muhammad Bilal; Mohammed Rafi Shaik; Syed Farooq Adil; Mohammed A.F. Sharaf; Emad Mahrous Awwad; Mujeeb Khan. Zirconium-Doped Chromium IV Oxide Nanocomposites: Synthesis, Characterization, and Photocatalysis towards the Degradation of Organic Dyes. Catalysts 2021, 11, 117 .
AMA StyleZahir Muhammad, Farman Ali, Muhammad Sajjad, Nisar Ali, Muhammad Bilal, Mohammed Rafi Shaik, Syed Farooq Adil, Mohammed A.F. Sharaf, Emad Mahrous Awwad, Mujeeb Khan. Zirconium-Doped Chromium IV Oxide Nanocomposites: Synthesis, Characterization, and Photocatalysis towards the Degradation of Organic Dyes. Catalysts. 2021; 11 (1):117.
Chicago/Turabian StyleZahir Muhammad; Farman Ali; Muhammad Sajjad; Nisar Ali; Muhammad Bilal; Mohammed Rafi Shaik; Syed Farooq Adil; Mohammed A.F. Sharaf; Emad Mahrous Awwad; Mujeeb Khan. 2021. "Zirconium-Doped Chromium IV Oxide Nanocomposites: Synthesis, Characterization, and Photocatalysis towards the Degradation of Organic Dyes." Catalysts 11, no. 1: 117.
The use of heterogeneous catalyst for biodiesel production can reduce the price of separation process and therefore minimize the biodiesel cost. ZnCuO/N-doped graphene (NDG) catalyst synthesized by facile mechanochemical procedure was tested in the transesterification of waste cooking oil (WCO) with methanol to produce biodiesel. The effects of catalyst loading (0–15 wt%), weight percentage of NDG (10–100%), methanol to oil molar ratio (6:1–18:1), reaction time (2–10 h) and reaction temperature (120–200 °C) were systematically studied at the optimal conditions. Additionally, the properties of the fabricated catalysts were assessed via XRD, FTIR, N2 sorption studies, HRTEM, TGA and Raman spectroscopy. It was found that the ZnCuO/(X%)NDG nanocomposites exhibit enhanced catalytic performance when compared with the ZnCuO catalyst (without NDG) under the identical conditions. The efficacy of the ZnCuO/(X%)NDG nanocomposites has improved owing to the inclusion of NDG in the catalytic system, which in-turn enhanced the properties of the mixed metal oxides (MMO’s) such as surface area, defective sites to a great extent. The ZnCuO/(30%)NDG catalyst displayed a highest catalytic activity towards transesterification of WCO (97.1%) at the optimized conditions of 10 wt% catalyst loading, 15:1 methanol:oil molar ratio, 8 h reaction time and 180 °C reaction temperature. Moreover, the recovered catalyst was successfully reused six cycles with no discernible loss in its activity.
Mufsir Kuniyil; J.V. Shanmukha Kumar; Syed Farooq Adil; Mohamed E. Assal; Mohammed Rafi Shaik; Mujeeb Khan; Abdulrahman Al-Warthan; Mohammed Rafiq H. Siddiqui. Production of biodiesel from waste cooking oil using ZnCuO/N-doped graphene nanocomposite as an efficient heterogeneous catalyst. Arabian Journal of Chemistry 2021, 14, 102982 .
AMA StyleMufsir Kuniyil, J.V. Shanmukha Kumar, Syed Farooq Adil, Mohamed E. Assal, Mohammed Rafi Shaik, Mujeeb Khan, Abdulrahman Al-Warthan, Mohammed Rafiq H. Siddiqui. Production of biodiesel from waste cooking oil using ZnCuO/N-doped graphene nanocomposite as an efficient heterogeneous catalyst. Arabian Journal of Chemistry. 2021; 14 (3):102982.
Chicago/Turabian StyleMufsir Kuniyil; J.V. Shanmukha Kumar; Syed Farooq Adil; Mohamed E. Assal; Mohammed Rafi Shaik; Mujeeb Khan; Abdulrahman Al-Warthan; Mohammed Rafiq H. Siddiqui. 2021. "Production of biodiesel from waste cooking oil using ZnCuO/N-doped graphene nanocomposite as an efficient heterogeneous catalyst." Arabian Journal of Chemistry 14, no. 3: 102982.
Humans have witnessed three deadly pandemics so far in the twenty-first century which are associated with novel coronaviruses: SARS, Middle East respiratory syndrome (MERS), and COVID-19. All of these viruses, which are responsible for causing acute respiratory tract infections (ARTIs), are highly contagious in nature and/or have caused high mortalities. The recently emerged COVID-19 disease is a highly transmittable viral infection caused by another zoonotic novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Similar to the other two coronaviruses such as SARS-CoV-1 and MERS-CoV, SARS-CoV-2 is also likely to have originated from bats, which have been serving as established reservoirs for various pathogenic coronaviruses. Although, it is still unknown how SARS-CoV-2 is transmitted from bats to humans, the rapid human-to-human transmission has been confirmed widely. The disease first appeared in Wuhan, China, in December 2019 and quickly spread across the globe, infected 48,539,872 people, and caused 1,232,791 deaths in 215 countries, and the infection is still spreading at the time of manuscript preparation. So far, there is no definite line of treatment which has been approved or vaccine which is available. However, different types of potential vaccines and therapeutics have been evaluated and/or are under clinical trials against COVID-19. In this review, we summarize different types of acute respiratory diseases and briefly discuss earlier outbreaks of coronaviruses and compare their occurrence and pathogenicity with the current COVID-19 pandemic. Various epidemiological aspects of COVID-19 such as mode of spread, death rate, doubling time, etc., have been discussed in detail. Apart from this, different technical issues related to the COVID-19 pandemic including use of masks and other socio-economic problems associated with the pandemic have also been summarized. Additionally, we have reviewed various aspects of patient management strategies including mechanism of action, available diagnostic tools, etc., and also discussed different strategies for the development of effective vaccines and therapeutic combinations to deal with this viral outbreak. Overall, by the inclusion of various references, this review covers, in detail, the most important aspects of the COVID-19 pandemic.
Mujeeb Khan; Syed F. Adil; Hamad Z. Alkhathlan; Muhammad N. Tahir; Sadia Saif; Merajuddin Khan; Shams T. Khan. COVID-19: A Global Challenge with Old History, Epidemiology and Progress So Far. Molecules 2020, 26, 39 .
AMA StyleMujeeb Khan, Syed F. Adil, Hamad Z. Alkhathlan, Muhammad N. Tahir, Sadia Saif, Merajuddin Khan, Shams T. Khan. COVID-19: A Global Challenge with Old History, Epidemiology and Progress So Far. Molecules. 2020; 26 (1):39.
Chicago/Turabian StyleMujeeb Khan; Syed F. Adil; Hamad Z. Alkhathlan; Muhammad N. Tahir; Sadia Saif; Merajuddin Khan; Shams T. Khan. 2020. "COVID-19: A Global Challenge with Old History, Epidemiology and Progress So Far." Molecules 26, no. 1: 39.
The authors report on the synthesis of Fe–NiO nanoparticles (Fe–NiO NPs) with a spherical shape via facile flash combustion synthesis. A structural test shows cubic formations of Fe–NiO NPs in all Fe concentrations. A reduction in crystallite size was observed with increasing Fe content from 27 nm to 12 nm. A vibrational study also indicates a cubic Fe–NiO NPs structure. However, slight shifts in peak positions were observed during Fe doping in NiO. The existence of Fe in NiO product was confirmed using energy dispersive X-ray (EDX) analysis, and its homogeneity in the final products was observed in scanning electron microscopy (SEM) e-mapping images. An X‐ray photoelectron spectroscopy (XPS) study was also carried out to confirm the incorporation of Fe in NiO matrix. A field-emission scanning electron microscopy (FESEM) study showed the formation of spherical nanoparticles in all Fe–NiO NPs samples. However, it was noted that the grain size reduced with increasing Fe content, which is in agreement with the X-ray diffraction (XRD) results. Transmission electron microscopy (TEM) and high-resolution TEM (HRTEM) with a selected area electron diffraction (SAED) curve indicate very low-dimension NP formation from NiO. An optical test was performed based on the Kubelka-Munk theory along with an estimation of energy gas, which showed an increase of 3.5–3.75 eV with Fe content doping in NiO. Furthermore, the possibility of applying spherical Fe–NiO NPs as an electrode material was also assessed in a three-electrode assembly cell, and the results show that the NiO doped with 5% of Fe exhibited superior capacitance performance (F4, 297.67 F g-1) compared to the other samples.
Aslam Khan; Mohd Shkir; Sajid Ali Ansari; Nazish Parveen; S. AlFaify; Ahmed Mohamed El-Toni; Ravindra Kumar Gupta; Syed Farooq Adil. One-pot flash combustion synthesis of [email protected] nanocomposites for supercapacitor applications. Ceramics International 2020, 47, 9024 -9033.
AMA StyleAslam Khan, Mohd Shkir, Sajid Ali Ansari, Nazish Parveen, S. AlFaify, Ahmed Mohamed El-Toni, Ravindra Kumar Gupta, Syed Farooq Adil. One-pot flash combustion synthesis of [email protected] nanocomposites for supercapacitor applications. Ceramics International. 2020; 47 (7):9024-9033.
Chicago/Turabian StyleAslam Khan; Mohd Shkir; Sajid Ali Ansari; Nazish Parveen; S. AlFaify; Ahmed Mohamed El-Toni; Ravindra Kumar Gupta; Syed Farooq Adil. 2020. "One-pot flash combustion synthesis of [email protected] nanocomposites for supercapacitor applications." Ceramics International 47, no. 7: 9024-9033.
The newly synthesized dinuclear uranyl salen coordination compound showed excellent photocatalytic reduction of CO2 to methanol.
Mohammad Azam; Umesh Kumar; Joshua O. Olowoyo; Saud I. Al-Resayes; Agata Trzesowska-Kruszynska; Rafal Kruszynski; Mohammadd Shahidul Islam; Mohammad Rizwan Khan; Syed Farooq Adil; Mohammad Rafique Siddiqui; Fahad Ahmed Al-Harthi; Abdul Karim Alinzi; Saikh Mohammad Wabaidur; Masoom Raza Siddiqui; Mohammed Rafi Shaik; Suman L. Jain; M. Amin Farkhondehfal; Simelys Hernàndez. Dinuclear uranium(vi) salen coordination compound: an efficient visible-light-active catalyst for selective reduction of CO2 to methanol. Dalton Transactions 2020, 49, 17243 -17251.
AMA StyleMohammad Azam, Umesh Kumar, Joshua O. Olowoyo, Saud I. Al-Resayes, Agata Trzesowska-Kruszynska, Rafal Kruszynski, Mohammadd Shahidul Islam, Mohammad Rizwan Khan, Syed Farooq Adil, Mohammad Rafique Siddiqui, Fahad Ahmed Al-Harthi, Abdul Karim Alinzi, Saikh Mohammad Wabaidur, Masoom Raza Siddiqui, Mohammed Rafi Shaik, Suman L. Jain, M. Amin Farkhondehfal, Simelys Hernàndez. Dinuclear uranium(vi) salen coordination compound: an efficient visible-light-active catalyst for selective reduction of CO2 to methanol. Dalton Transactions. 2020; 49 (47):17243-17251.
Chicago/Turabian StyleMohammad Azam; Umesh Kumar; Joshua O. Olowoyo; Saud I. Al-Resayes; Agata Trzesowska-Kruszynska; Rafal Kruszynski; Mohammadd Shahidul Islam; Mohammad Rizwan Khan; Syed Farooq Adil; Mohammad Rafique Siddiqui; Fahad Ahmed Al-Harthi; Abdul Karim Alinzi; Saikh Mohammad Wabaidur; Masoom Raza Siddiqui; Mohammed Rafi Shaik; Suman L. Jain; M. Amin Farkhondehfal; Simelys Hernàndez. 2020. "Dinuclear uranium(vi) salen coordination compound: an efficient visible-light-active catalyst for selective reduction of CO2 to methanol." Dalton Transactions 49, no. 47: 17243-17251.
A new series of coumarin-yl-chalcone derivatives (3a-m) had been designed and synthesized through different reactions such as aromatic addition, cyclization and Claisen-Schmidt reactions in good yields (54-78%). 5-acetyl-4-(2-hydroxyphenyl) -6-methyl-3, 4-dihydropyrimidin-2(1H) -one (1) has been synthesized by the reaction of salicylaldehyde, methyl acetoacetate, urea and citric acid which was further reacted with malonic acid to yield 5-acetyl-4-(4-hydroxy-2-oxo-2H-chromen-8-yl) -6-methyl-3, 4-dihydropyrimidin-2(1H) -one (2). The titled compounds (3a-m) were synthesised by reacting 5-acetyl-4-(4-hydroxy-2-oxo-2H-chromen-8-yl) -6-methyl-3, 4-dihydropyrimidin-2(1H) -one (2) with different aromatic aldehydes in the presence of sodium hydroxide. In-silico studies, a preliminary screening method for predicting the anti-cancer activity was performed for the synthesized compounds (3a-m) against Src, Alb tyrosine kinase and homology model protein (PDB ID: 4csv). The derivatives 3h and 3m showed moderate binding energies. The in vitro cytotoxic activity was evaluated for the compounds 3h and 3m by using human cancer cell-line morphology and MTT assay against three human cell-lines A549 (Lung), Jurkat (Leukemia) and MCF-7 (Breast). The results indicate that the derivatives 3h and 3m display significant anti-cancer activity, however it was found to be less cytotoxic when compared to the standard used i.e. Imatinib.
Konidala Sathish Kumar; Vijay Kotra; Phani Kumar Kola; Ch.B. Praveena Devi; Nutakki Anusha; Bollikolla Hari Babu; Syed Farooq Adil; Mohammed Rafi Shaik; Mujeeb Khan; Abdulrahman Al-Warthan; Osamah Alduhaish; M. Mujahid Alam. ZnCl2 catalyzed new coumarinyl-chalcones as cytotoxic agents. Saudi Journal of Biological Sciences 2020, 28, 386 -394.
AMA StyleKonidala Sathish Kumar, Vijay Kotra, Phani Kumar Kola, Ch.B. Praveena Devi, Nutakki Anusha, Bollikolla Hari Babu, Syed Farooq Adil, Mohammed Rafi Shaik, Mujeeb Khan, Abdulrahman Al-Warthan, Osamah Alduhaish, M. Mujahid Alam. ZnCl2 catalyzed new coumarinyl-chalcones as cytotoxic agents. Saudi Journal of Biological Sciences. 2020; 28 (1):386-394.
Chicago/Turabian StyleKonidala Sathish Kumar; Vijay Kotra; Phani Kumar Kola; Ch.B. Praveena Devi; Nutakki Anusha; Bollikolla Hari Babu; Syed Farooq Adil; Mohammed Rafi Shaik; Mujeeb Khan; Abdulrahman Al-Warthan; Osamah Alduhaish; M. Mujahid Alam. 2020. "ZnCl2 catalyzed new coumarinyl-chalcones as cytotoxic agents." Saudi Journal of Biological Sciences 28, no. 1: 386-394.
In recent years, the development of green mechanochemical processes for the synthesis of new catalysts with higher catalytic efficacy and selectivity has received manifest interest. In continuation of our previous study, in which graphene oxide (GRO) and highly reduced graphene oxide (HRG) based nanocomposites were prepared and assessed, herein, we have explored a facile and solvent-less mechanochemical approach for the synthesis of N-doped graphene (NDG)/mixed metal oxide (MnCO3–ZrO2) ((X%)NDG/MnCO3–ZrO2), as the (X%)NDG/MnCO3–ZrO2 nano-composite was synthesized using physical grinding of separately synthesized NDG and pre-calcined (300 °C) MnCO3–ZrO2 via green milling method. The structures of the prepared materials were characterized in detail using X-ray powder diffraction (XRD), Field Emission Scanning Electron Microscope (FESEM), Energy Dispersive X-Ray Analysis (EDX), Fourier-transform infrared spectroscopy (FTIR), Raman, Thermogravimetric analysis (TGA), and N2 adsorption-desorption isotherm analysis. Besides, the obtained nanocomposites were employed as heterogeneous oxidation catalyst for the alcohol oxidation using green oxidant O2 without involving any surfactants or bases. The reaction factors were systematically studied during the oxidation of benzyl alcohol (PhCH2OH) as the model reactant to benzaldehyde (PhCHO). The NDG/MnCO3–ZrO2 exhibits premium specific activity (66.7 mmol·g−1·h−1) with 100% conversion of PhCH2OH and > 99.9% selectivity to PhCHO after only 6 min. The mechanochemically prepared NDG based nanocomposite exhibited notable improvement in the catalytic efficacy as well as the surface area compared to the pristine MnCO3–ZrO2. Under the optimal circumstances, the NDG/MnCO3–ZrO2 catalyst could selectively catalyze the aerobic oxidation of a broad array of alcohols to carbonyls with full convertibility without over-oxidized side products like acids. The NDG/MnCO3–ZrO2 catalyst were efficiently reused for six subsequent recycling reactions with a marginal decline in performance and selectivity.
Mufsir Kuniyil; J. V. Shanmukha Kumar; Syed Farooq Adil; Mohamed E. Assal; Mohammed Rafi Shaik; Mujeeb Khan; Abdulrahman Al-Warthan; Mohammed Rafiq H. Siddiqui; Aslam Khan; Muhammad Bilal; Hafiz M. N. Iqbal; Waheed A. Al-Masry. Eco-Friendly and Solvent-Less Mechanochemical Synthesis of ZrO2–MnCO3/N-Doped Graphene Nanocomposites: A Highly Efficacious Catalyst for Base-Free Aerobic Oxidation of Various Types of Alcohols. Catalysts 2020, 10, 1136 .
AMA StyleMufsir Kuniyil, J. V. Shanmukha Kumar, Syed Farooq Adil, Mohamed E. Assal, Mohammed Rafi Shaik, Mujeeb Khan, Abdulrahman Al-Warthan, Mohammed Rafiq H. Siddiqui, Aslam Khan, Muhammad Bilal, Hafiz M. N. Iqbal, Waheed A. Al-Masry. Eco-Friendly and Solvent-Less Mechanochemical Synthesis of ZrO2–MnCO3/N-Doped Graphene Nanocomposites: A Highly Efficacious Catalyst for Base-Free Aerobic Oxidation of Various Types of Alcohols. Catalysts. 2020; 10 (10):1136.
Chicago/Turabian StyleMufsir Kuniyil; J. V. Shanmukha Kumar; Syed Farooq Adil; Mohamed E. Assal; Mohammed Rafi Shaik; Mujeeb Khan; Abdulrahman Al-Warthan; Mohammed Rafiq H. Siddiqui; Aslam Khan; Muhammad Bilal; Hafiz M. N. Iqbal; Waheed A. Al-Masry. 2020. "Eco-Friendly and Solvent-Less Mechanochemical Synthesis of ZrO2–MnCO3/N-Doped Graphene Nanocomposites: A Highly Efficacious Catalyst for Base-Free Aerobic Oxidation of Various Types of Alcohols." Catalysts 10, no. 10: 1136.
The Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that originated in Chinese city of Wuhan has caused around 906,092 deaths and 28,040,853 confirmed cases worldwide (https://covid19.who.int/, 11 September 2020). In a life-threatening situation, where there is no specific and licensed anti-COVID-19 vaccine or medicine available; the repurposed drug might act as a silver bullet. Currently, more than 211 vaccines, 80 antibodies, 31 antiviral drugs, 35 cell-based, 6 RNA-based and 131 other drugs are in clinical trials. It is therefore utter need of the hour to develop an effective drug that can be used for the treatment of COVID-19 before a vaccine can be developed. One of the best-characterized and attractive drug targets among coronaviruses is the main protease (3CLpro). Therefore, the current study focuses on the molecular docking analysis of TAT-peptide47–57 (GRKKRRQRRRP)-conjugated repurposed drugs (i.e., lopinavir, ritonavir, favipiravir, and hydroxychloroquine) with SARS-CoV-2 main protease (3CLpro) to discover potential efficacy of TAT-peptide (TP) - conjugated repurposing drugs against SARS-CoV-2. The molecular docking results validated that TP-conjugated ritonavir, lopinavir, favipiravir, and hydroxychloroquine have superior and significantly enhanced interactions with the target SARS-CoV-2 main protease. In-silico approach employed in this study suggests that the combination of the drug with TP is an excelling alternative to develop a novel drug for the treatment of SARS-CoV-2 infected patients. The development of TP based delivery of repurposing drugs might be an excellent approach to enhance the efficacy of the existing drugs for the treatment of COVID-19. The predictions from the results obtained provide invaluable information that can be utilized for the choice of candidate drugs for in vitro, in vivo and clinical trials. The outcome from this work prove crucial for exploring and developing novel cost-effective and biocompatible TP conjugated anti-SARS-CoV-2 therapeutic agents in immediate future.
Mohammad Azam Ansari; Qazi Mohammad Sajid Jamal; Suriya Rehman; Ahmad Almatroudi; Mohammad A. Alzohairy; Mohammad N. Alomary; Takshashila Tripathi; Ali H. Alharbi; Syed Farooq Adil; Mujeeb Khan; M. Shaheer Malik. TAT-peptide conjugated repurposing drug against SARS-CoV-2 main protease (3CLpro): Potential therapeutic intervention to combat COVID-19. Arabian Journal of Chemistry 2020, 13, 8069 -8079.
AMA StyleMohammad Azam Ansari, Qazi Mohammad Sajid Jamal, Suriya Rehman, Ahmad Almatroudi, Mohammad A. Alzohairy, Mohammad N. Alomary, Takshashila Tripathi, Ali H. Alharbi, Syed Farooq Adil, Mujeeb Khan, M. Shaheer Malik. TAT-peptide conjugated repurposing drug against SARS-CoV-2 main protease (3CLpro): Potential therapeutic intervention to combat COVID-19. Arabian Journal of Chemistry. 2020; 13 (11):8069-8079.
Chicago/Turabian StyleMohammad Azam Ansari; Qazi Mohammad Sajid Jamal; Suriya Rehman; Ahmad Almatroudi; Mohammad A. Alzohairy; Mohammad N. Alomary; Takshashila Tripathi; Ali H. Alharbi; Syed Farooq Adil; Mujeeb Khan; M. Shaheer Malik. 2020. "TAT-peptide conjugated repurposing drug against SARS-CoV-2 main protease (3CLpro): Potential therapeutic intervention to combat COVID-19." Arabian Journal of Chemistry 13, no. 11: 8069-8079.
Plant extract of Pulicaria undulata (L.) was used as both reducing agent and stabilizing ligand for the rapid and green synthesis of gold (Au), silver (Ag), and gold–silver (Au–Ag) bimetallic (phase segregated/alloy) nanoparticles (NPs). These nanoparticles with different morphologies were prepared in two hours by stirring corresponding metal precursors in the aqueous solution of the plant extracts at ambient temperature. To infer the role of concentration of plant extract on the composition and morphology of NPs, we designed two different sets of experiments, namely (i) low concentration (LC) and (ii) high concentration (HC) of plant extract. In the case of using low concentration of the plant extract, irregular shaped Au, Ag, or phase segregated Au–Ag bimetallic NPs were obtained, whereas the use of higher concentrations of the plant extract resulted in the formation of spherical Au, Ag, and Au–Ag alloy NPs. The as-prepared Au, Ag, and Au–Ag bimetallic NPs showed morphology and composition dependent catalytic activity for the reduction of 4-nitrophenol (4-NPh) to 4-aminophenol (4-APh) in the presence of NaBH4. The bimetallic Au–Ag alloy NPs showed the highest catalytic activity compared to all other NPs.
Merajuddin Khan; Khaleel Al-Hamoud; Zainab Liaqat; Mohammed Rafi Shaik; Syed Farooq Adil; Mufsir Kuniyil; Hamad Z. Alkhathlan; Abdulrahman Al-Warthan; Mohammed Rafiq H. Siddiqui; Mihail Mondeshki; Wolfgang Tremel; Mujeeb Khan; Muhammad Nawaz Tahir. Synthesis of Au, Ag, and Au–Ag Bimetallic Nanoparticles Using Pulicaria undulata Extract and Their Catalytic Activity for the Reduction of 4-Nitrophenol. Nanomaterials 2020, 10, 1885 .
AMA StyleMerajuddin Khan, Khaleel Al-Hamoud, Zainab Liaqat, Mohammed Rafi Shaik, Syed Farooq Adil, Mufsir Kuniyil, Hamad Z. Alkhathlan, Abdulrahman Al-Warthan, Mohammed Rafiq H. Siddiqui, Mihail Mondeshki, Wolfgang Tremel, Mujeeb Khan, Muhammad Nawaz Tahir. Synthesis of Au, Ag, and Au–Ag Bimetallic Nanoparticles Using Pulicaria undulata Extract and Their Catalytic Activity for the Reduction of 4-Nitrophenol. Nanomaterials. 2020; 10 (9):1885.
Chicago/Turabian StyleMerajuddin Khan; Khaleel Al-Hamoud; Zainab Liaqat; Mohammed Rafi Shaik; Syed Farooq Adil; Mufsir Kuniyil; Hamad Z. Alkhathlan; Abdulrahman Al-Warthan; Mohammed Rafiq H. Siddiqui; Mihail Mondeshki; Wolfgang Tremel; Mujeeb Khan; Muhammad Nawaz Tahir. 2020. "Synthesis of Au, Ag, and Au–Ag Bimetallic Nanoparticles Using Pulicaria undulata Extract and Their Catalytic Activity for the Reduction of 4-Nitrophenol." Nanomaterials 10, no. 9: 1885.
An efficient metal-free domino reaction leading to structural/electronically divergent 1,2-dihydropyridines from easily accessible propargyl vinyl anilines via N-phenyl 3-aza-Cope sigmatropic rearrangement is reported with good to excellent yields using 1,2-dichlorobenzene as solvent under thermal conditions. Spirocyclic substitution is also tolerated under the present optimized conditions.
Osamah Alduhaish; Ravi Varala; Syed Farooq Adil; Mujeeb Khan; Mohammed Rafiq H. Siddiqui; Abdulrhman Alwarthan; M. Mujahid Alam. Synthesis of 1,2-Dihydro-Substituted Aniline Analogues Involving N-Phenyl-3-aza-Cope Rearrangement Using a Metal-Free Catalytic Approach. Journal of Chemistry 2020, 2020, 1 -8.
AMA StyleOsamah Alduhaish, Ravi Varala, Syed Farooq Adil, Mujeeb Khan, Mohammed Rafiq H. Siddiqui, Abdulrhman Alwarthan, M. Mujahid Alam. Synthesis of 1,2-Dihydro-Substituted Aniline Analogues Involving N-Phenyl-3-aza-Cope Rearrangement Using a Metal-Free Catalytic Approach. Journal of Chemistry. 2020; 2020 ():1-8.
Chicago/Turabian StyleOsamah Alduhaish; Ravi Varala; Syed Farooq Adil; Mujeeb Khan; Mohammed Rafiq H. Siddiqui; Abdulrhman Alwarthan; M. Mujahid Alam. 2020. "Synthesis of 1,2-Dihydro-Substituted Aniline Analogues Involving N-Phenyl-3-aza-Cope Rearrangement Using a Metal-Free Catalytic Approach." Journal of Chemistry 2020, no. : 1-8.