Anum Rauf

Ms. Anum Rauf


Research Focus & Metrics

Academic Career Length

6Years (2021-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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5 March 2021 in Applied Sciences
Verified
Journal Article
Open access
PDF file
ARAnum Rauf
Anum Rauf
AKAqsa Kiran
Aqsa Kiran
Malik Tahir HassanMalik Tahir Hassan
Malik Tahir Hassan
SMSajid Mahmood
Sajid Mahmood
GMGhulam Mustafa
Ghulam Mustafa
Moongu JeonMoongu Jeon
Moongu Jeon
Heart attack and other heart-related diseases are among the main causes of fatalities in the world. These diseases and some other severe problems like kidney failure and paralysis are mainly caused by hypertension. Since bioactive peptides extracted from naturally existing food substances possess antihypertensive activity, these antihypertensive peptides (AHTP) can function as prospective replacements for existing pharmacological drugs with no or fewer side effects. Such naturally existing peptides can be identified using in-silico approaches. The in-silico methods have been proven to save huge amounts of time and money in the identification of effective peptides. The proposed methodology is a deep learning-based in-silico approach for the identification of antihypertensive peptides (AHTPs). An ensemble method is proposed that combines convolutional neural network (CNN) and support vector machine (SVM) classifiers. Amino acid composition (AAC) and g-gap dipeptide composition (DPC) techniques are used for feature extraction. The proposed methodology has been evaluated on two standard antihypertensive peptide sequence datasets. The model yields 95% accuracy on the benchmarking dataset and 88.9% accuracy on the independent dataset. Comparative analysis is provided to demonstrate that the proposed method outperforms existing state-of-the-art methods on both of the benchmarking and independent datasets.