This study aimed to analyze medication adherence and persistence among open-angle glaucoma patients in Korea. A retrospective study was conducted using the Korean National Health Insurance (NHI) claims database from 2016 to 2019. Newly diagnosed open-angle glaucoma patients who were prescribed with the intraocular pressure (IOP)-lowering eyedrops were included. Adherence was measured using the medication possession ratio (MPR), and persistence was measured using the duration of therapy during the 24 month follow-up period. During the study period, 14,648 open-angle glaucoma patients were identified, and 3118 (21.3%) and 4481 patients (30.6%) were adherent to and persistent with their glaucoma treatment, respectively. The mean MPR was 48.8%, and the mean duration of therapy was 357.2 days. Logistic regression analysis showed that patients who are older, female, using prostaglandins as the index medication, and visiting secondary or tertiary hospitals were significantly associated with greater rates of adherence (odds ratio (OR) = 1.21, 1.12, 1.27, and 1.73, respectively) and persistence (OR = 1.11, 1.17, 1.16, 1.17, and 1.36, respectively) during the study period. Patients with open-angle glaucoma in Korea had substandard medication adherence and discontinued their treatment. Ophthalmologists should pay more attention to younger, male patients to improve adherence.

Light-activated nanozymes possess several advantages, such as light-mediated activity regulation, utilization of molecular oxygen as a green oxidant, and highly enhanced activity; however, the types of light-activated nanozymes are still limited. In this study, we found that Mg aminoclay-based Fe₃O₄/TiO₂ hybrids (MgAC-Fe₃O₄/TiO₂) exhibited peroxidase-like catalytic activity to catalyze the oxidation of the peroxidase substrate 2,2′-azino-bis(3-ethylbenzo-thiazoline-6-sulfonic acid) diammonium salt (ABTS) in the presence of H₂O₂, which was significantly enhanced under ultraviolet (UV)-light irradiation. Compared with MgAC-Fe₃O₄ and MgAC-TiO₂, MgAC-Fe₃O₄/TiO₂ showed around three-fold enhancement in the absorption intensity corresponding to the oxidized ABTS under UV-light irradiation, presumably due to the synergistic effect between Fe₃O₄ and TiO₂, thereby facilitating photocatalytic electron transfer during the catalytic action. In addition, the MgAC-Fe₃O₄/TiO₂ showed vivid stability enhancement in wide range of pH and temperature values compared with natural peroxidase. The UV-light-driven MgAC-Fe₃O₄/TiO₂-based system was successfully applied for the colorimetric detection of phenolic compounds, including pyrocatechol and resorcinol, in a dynamic linear range of 0.15–1.30 mg/mL with a limit of detection as low as 0.1 mg/mL. Further, the system could successfully determine the phenolic compounds in spiked tap water, and thus, it can be used for practical applications. We believe that the UV-light-driven enhancement in the peroxidase-like catalytic performances highlights the potential of MgAC-Fe₃O₄/TiO₂ for detecting phenolic compounds as well as other clinically and environmentally important substances.