Several Indigenous edible vegetables in sub-Saharan countries have potential bioactive compounds, including underutilized Biden pilosa (BP). Bioactives from Indigenous edible vegetables are re-evolving as an alternative medicine potential for drug formulations. BP has also been used to mitigate over 40 different diseases in people and animals as herbal medication. Due to globalization and urbanization, people move from more active to more sedentary lifestyles, home-cooked meals to fast foods and snacks, organic foods to processed food with high sugar, salt, and fat. The consumption of native fruits and vegetables is now replaced by a highly processed calory diet, leading to metabolic syndromes such as diabetes, obesity, and other diet-related non-communicable diseases. Hence this article was designed to investigate the existing reports on the use, knowledge and the need to utilize the potentiality of BP further to overcome nutritional deficiencies, food scarcity and mitigation of medical conditions in sub-Saharan Africa. The use of plant-based drugs will aid to decrease the health capitation load as most countries do not have enough funds for purchasing synthetic chemicals used to mitigate diseases.

Active chemicals are among the contaminants of emerging concern that are rarely covered in regulatory documents in sub-Saharan Africa. These substances are neither in the list of routinely monitored substances nor in the guidelines for routine environmental monitoring activities. This has been of concern to public health officials, toxicologists, communities, and governments, hence the need for risk assessment and regulation of these substances. In this review article, the presence of active chemicals in the sub-Saharan African environment was investigated. The results indicate the availability of few studies in some countries, while in other countries no reports of active chemicals were found, hence the need for further research targeting such countries. It was further observed that mixtures of active chemicals from different therapeutic categories—such as antibiotics and analgesics—were reported. The natural environment is increasingly at risk due to the presence of these substances, their metabolites, and their transformation byproducts. These substances are characterized by persistence as a result of their non-biodegradable nature; hence, they circulate from one environmental compartment to another through the food chain, causing harm along the way. Most studies that evaluated the toxicity of these substances considered the effects of a single drug, but observations indicated the presence of drug mixtures, hence the need for further evaluation of the effects of drug–drug interactions—including synergistic and additive effects—for environmental sustainability. The presence of ACs in several environmental compartments at quantifiable quantities was discovered in this investigation, indicating the potential for ecosystem injury as a result of bioaccumulation, bioconcentration, and biomagnification through the food chain. This necessitates further research on the subject in order to ensure a healthier environment.

Turmeric (Curcuma longa) has been a famous root crop for its medicinal properties since pre-historical times. Lack of effective therapeutics for most viral diseases, higher cost of some antiviral therapies, and the emergence of antiviral drug resistance are increasingly reported. Drug resistance is predicted to be a leading cause of mortality globally by 2050, thus requiring intervention. The need for effective natural antiviral compounds to mitigate viral diseases, such as curcumin, calls for further studies. Curcumin, a primary curcuminoid compound, has demonstrated a broad activity as an antiviral agent. Due to the need to overcome drug resistance to chemically synthesised drugs, the best option is to improve and adapt the use of natural antiviral agents. The antiviral potential of curcumin is hindered by its solubility and bioavailability. Recently, different techniques, such as the preparation of curcumin carbon quantum dots, have been used to improve curcumin antiviral activity. Therefore, the current review aims to assess curcumin’s benefits as a natural antiviral agent and techniques to improve its medicinal activity. Future use of curcumin will aid in mitigating viral diseases, including resistant strain, hence sustainability of the entire community. In this case, research and innovation are required to improve the solubility and bioavailability of curcumin for medical uses.

The escalating burden of antimicrobial pollution in East Africa poses severe threats to public health, environmental integrity, and economic stability. Environmental compartments such as soil and water serve as reservoirs for these pollutants such as antimicrobials and antibiotic resistance genes, creating selective pressure that accelerates the emergence of antimicrobial resistance (AMR). These dynamic fosters the proliferation of multidrug-resistant pathogens, or "superbugs," complicating infection management and amplifying health risks in a region already challenged by inadequate healthcare and sanitation infrastructure. Furthermore, pollution by antimicrobials and antibiotic resistance genes critically disrupts ecological processes, such as nutrient cycling and organic matter degradation, diminishing soil fertility, water quality, and agricultural productivity, thereby threatening food security and overall ecological health. Current surveillance efforts, including the Global Antimicrobial Resistance and Use Surveillance System (GLASS) and the East Africa Public Health Laboratory Networking Project (EAPHLNP), have made strides in tracking AMR trends and guiding policy decisions. However, these efforts remain insufficient to address the growing crisis. This study highlights the urgent need for integrated strategies, including stringent antibiotic usage regulations, advanced wastewater treatment technologies, and comprehensive environmental surveillance. Therefore, there is a need to address the intersections of health, agriculture, and environment, to mitigate AMR and its far-reaching consequences to ensure public health safety and sustainability.

Galinsoga parviflora (Cav.) is a member of the Asteraceae family traditionally used for treatment of various ailments such as malaria, flu, cold, colorectal cancer, liver problems and inflammation. The medicinal properties of G. parviflora are due to the presence of various secondary metabolites including flavonoids, saponins, terpenoids and tannins. The literature survey revealed that G. parviflora possesses several pharmacological properties such as antibacterial, antifungal, antioxidant and antidiabetic. This review systematically discusses the potential of G. parviflora for managing medical conditions. The information is collected from various online databases such as Google Scholar, ScienceDirect, Springer, Web of Science, Plant of the World Online and PubMed. Among other information provided in this review, ethnomedicinal uses, phytochemistry and pharmacological activities are discussed extensively. Additonally, the potential benefits, challenges and future opportunities are presented.