Matthias G. Wacker

Dr. Matthias G. Wacker

National University of Singapore
orcid

Research Focus & Metrics

Academic Career Length

18Years (2009-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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14 April 2023 in Science Advances
Verified
Journal Article
Open access
LTLingjun Tong
Lingjun Tong
SZSitong Zhang
Sitong Zhang
QLQiqi Liu
Qiqi Liu
CHChenyuan Huang
Chenyuan Huang
HHHaining Hao
Haining Hao
Jiong-Wei WangJiong-Wei Wang
Jiong-Wei Wang
Milk-derived extracellular vesicles (mEVs) have been proposed as a potential nanomedicine for intestinal disorders; however, their impact on intestinal barrier integrity in gut inflammation and associated metabolic diseases has not been explored yet. Here, mEVs derived from bovine and human breast milk exert similar protective effects on epithelial tight junction functionality in vitro, survive harsh gastrointestinal conditions ex vivo, and reach the colon in vivo. Oral administration of mEVs restores gut barrier integrity at multiple levels, including mucus, epithelial, and immune barriers, and prevents endotoxin translocation into the liver in chemical-induced experimental colitis and diet-induced nonalcoholic steatohepatitis (NASH), thereby alleviating gut disorders, their associated liver inflammation, and NASH. Oral administration of mEVs has potential in the treatment of gut inflammation and gut-liver axis–associated metabolic diseases via protection of intestinal barrier integrity.

1 November 2013 in International Journal of Pharmaceutics
Verified
Journal Article
Closed access
MWMatthias G. Wacker
Matthias G. Wacker

1 November 2019 in Advanced Drug Delivery Reviews
Verified
Journal Article
Closed access
MMMargareth R.C. Marques
Margareth R.C. Marques
QCQiuyi Choo
Qiuyi Choo
MAMukul Ashtikar
Mukul Ashtikar
TRThais Correa Rocha
Thais Correa Rocha
SBSusanne Bremer-Hoffmann
Susanne Bremer-Hoffmann
MWMatthias G. Wacker
Matthias G. Wacker

1 July 2016 in International Journal of Pharmaceutics
Verified
Journal Article
Closed access
MWMatthias G. Wacker
Matthias G. Wacker
Ana ProykovaAna Proykova
Ana Proykova
GSGustavo Mendes Lima Santos
Gustavo Mendes Lima Santos

1 July 2009 in Journal of Photochemistry and Photobiology B: Biology
Verified
Journal Article
Closed access
KCKuan Chen
Kuan Chen
APAnnegret Preuß
Annegret Preuß
SHSteffen Hackbarth
Steffen Hackbarth
MWMatthias G. Wacker
Matthias G. Wacker
DLDr. Klaus Langer
Dr. Klaus Langer
BRBeate Röder
Beate Röder

1 April 2018 in Advanced Drug Delivery Reviews
Verified
Journal Article
Closed access
MAMukul Ashtikar
Mukul Ashtikar
MWMatthias G. Wacker
Matthias G. Wacker