Laura Stefani

Dr. Laura Stefani

Sport Medicine Center, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
orcid

Research Focus & Metrics

Academic Career Length

25Years (2002-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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8 April 2009 in Cardiovascular Ultrasound
Verified
Journal Article
Open access
PDF file
Laura StefaniLaura Stefani
Laura Stefani
GPGianni Pedrizzetti
Gianni Pedrizzetti
ALAlessio De Luca
Alessio De Luca
RMRoberto Mercuri
Roberto Mercuri
GIGabriele Innocenti
Gabriele Innocenti
GGGiorgio GALANTI
Giorgio GALANTI
Strain, and particularly Longitudinal Peak Systolic Strain (LPSS), plays a role in investigating the segmental and overall contractility of the heart which is a particularly interesting feature in athletes in whom regular training determines several morphological and functional modifications in both the ventricles, that normally work at different loads. Speckle tracking techniques assess the LPSS of LV and RV from B-mode imaging in real time, with uniform accuracy in all segments, and can verify the possible dissimilar segmental contributions of the two chambers to overall myocardial contraction. The aim of the study is to quantify the LPSS in real time in both the ventricles in order to estimate any possible different deformation properties in them during a systolic period.

Verified
Journal Article
Open access
PDF file
Laura StefaniLaura Stefani
Laura Stefani
GGGiorgio GALANTI
Giorgio GALANTI
Riggs KlikaRiggs Klika
Riggs Klika
The goal of cancer treatment is to arrest or eradicate the tumor while minimizing the often toxic effects of treatment. While oncologic diagnostics and treatments are improving and survival rates are increasing, it is critical to provide additional patient management that appears to affect long-term survival. Epidemiologic evidence suggests patients diagnosed with cancer tend to fair better after treatment when following a comprehensive rehabilitation program aimed at achieving an ideal body weight through dietary and exercise interventions while also increasing cardiorespiratory fitness, strength, mobility, neuromuscular integrity and psycho-social wellbeing. Additionally, it is now being tested whether exercise during cancer treatment and possibly prior to the start of treatment may increase post treatment outcomes by altering body weight, having direct effects on tumorigenesis, reducing oxidative stress and inflammation, and perhaps increasing chemotherapy delivery efficacy. The purpose of this review is to outline an evidence based model to evaluate cancer patients and provide guidelines for post-cancer treatment rehabilitation programs. Additionally, strategies aimed at changing lifestyle habits such as smoking and poor dietary habits will be addressed.

16 September 2017
Verified
Book Chapter
Closed access
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Laura StefaniLaura Stefani
Laura Stefani
GGGiorgio GALANTI
Giorgio GALANTI

4 June 2007 in British Journal of Sports Medicine
Verified
Journal Article
Closed access
PDF file
Laura StefaniLaura Stefani
Laura Stefani
GGGiorgio GALANTI
Giorgio GALANTI
LTL Toncelli
L Toncelli
PMP Manetti
P Manetti
MVM C Vono
M C Vono
NMN Maffulli
N Maffulli
Aim: Bicuspid aortic valve (BAV) is a common congenital cardiac condition. The presence of BAV in non-elite athletes has been poorly investigated; it is usually asymptomatic until valvular stenosis, regurgitation or other vascular alterations are evident. Design: Over a three-year period, 2273 competitive athletes were consecutively investigated with transthoracic echocardiography. The traditional parameters, the aortic root dimensions at four levels and the systolic and diastolic flow of aortic valve, were studied with continuous Doppler according to the echo guidelines. Setting: The study protocol included all the non-elite athletes investigated for the first evaluation to obtain eligibility. Patients: 2273 competitive athletes aged 8–60 years from several sports and regularly trained were evaluated with anamnesis, clinical check-up and echocardiography in order to exclude subjects with systemic or congenital heart disease. Results: BAV was diagnosed in 58 athletes (2.5%). Of these, nine had normal valvular function, 47 had abnormal valvular function with mild–moderate aortic regurgitation, and two had moderate stenosis. Aortic root dimensions at all levels were significantly greater in athletes with BAV than in athletes with a normal tricuspid valve. No relation was found with age, body surface area, aortic regurgitation or years of training. Conclusions: BAV is a relatively common congenital cardiac disease in athletes and commonly asymptomatic for a long time. This study suggests the usefulness of evaluating young athletes using echocardiography at least once when they start their sporting activity.

27 January 2009 in European Heart Journal - Cardiovascular Imaging
Verified
Journal Article
Open access
PDF file
Laura StefaniLaura Stefani
Laura Stefani
ALAlessio De Luca
Alessio De Luca
NMNicola Maffulli
Nicola Maffulli
RMRoberto Mercuri
Roberto Mercuri
GIGabriele Innocenti
Gabriele Innocenti
GGGiorgio GALANTI
Giorgio GALANTI
Longitudinal peak systolic strain (LPSS) quantifies regional and global heart function. Few data are available on left ventricle (LV) performance in young athletes with bicuspid aortic valve (BAV), where a pattern of mild aortic insufficiency is relatively frequent, and the ejection fraction (EF) is often normal for a long time. We report the measurement of LV strain in young BAV athletes. Three groups (20 athletes with BAV, 20 healthy athletes, and 20 sedentary healthy subjects, all aged 25 ± 3 years) underwent standard echo examination to evaluate LPSS at the basal and medium-apical segments of the lateral wall (LW) and interventricular septum (IVS) of the LV. LPSS was within the normal range; however, in BAV athletes, the LPSS of the basal segments tended to be lower ( S %IVS basal , −17.7 ± 2.7; S %LW basal , −14.2 ± 2.2; S %IVS med-apic , −21 ± 3.5; S %LW med-apic , −18.8 ± 4.2), producing a gradient from basal to apical regions. The EF was normal in all subjects. Young trained BAV athletes have normal LV performance. Nevertheless, these athletes tend to have lower strain than healthy subjects in the LV basal segments. The clinical implications of this finding are uncertain and require further investigation.

1 January 2007 in Cardiovascular Ultrasound
Verified
Journal Article
Open access
Laura StefaniLaura Stefani
Laura Stefani
LTLoira Toncelli
Loira Toncelli
MGMarco Gianassi
Marco Gianassi
PMPaolo Manetti
Paolo Manetti
VTValentina Di Tante
Valentina Di Tante
GGGiorgio GALANTI
Giorgio GALANTI
Myocardial contractility can be investigated using longitudinal peak strain. It can be calculated using the Doppler-derived TDI method and the non-Doppler method based on tissue tracking on B-mode images. Both are validated and show good reproducibility, but no comparative analysis of their results has yet been conducted. This study analyzes the results obtained from the basal segments of the ventricular chambers in a group of athletes. 30 regularly-trained athletes were submitted to an echocardiography at rest and after handgrip. Starting from the four-chamber view, overall myocardial function and regional velocities were evaluated. The images obtained were processed to determine strain in left and right ventricle basal segments. Strain was calculated using the TDI method and a validated "speckle tracking" or, more correctly, "feature tracking" algorithm. The statistical analysis included a Student's t-test (p < 0.05). The range of strain values obtained is in agreement with the data reported in the literature. In the left ventricle (LV) the average strain values of the basal segments calculated with TDI on IVS and LW at rest and after stress were: -21.05 +/- 3.31; -20.41 +/- 2.99 and -20.05 +/- 2.61; -21.20 +/- 2.37, respectively. In the right ventricle (RV) the same method gave IVS and LW strain values at rest of -22.22 +/- 2.58 ; -24.42 +/- 5.84, and after HG of -22.02 +/- 5.20 ;-23.93 +/- 6.34. The values obtained using feature tracking were: LV at rest -20.48 +/- 2.65 for IVS, and -21.25 +/- 2.85 for LW; LV after HG: -19.48 +/- 3 for IVS and -21.69 +/- 3.85 for LW. In RV at rest: -21.46 +/- 3.25 for IVS and -24.13 +/- 5.86 for LW; RV after HG: -24.79 +/- 7.9 for IVS and -24.13 +/- 7.0 for LW. Tissue Doppler and "feature tracking" methods showed the respective consistency of the results in the basal segments of myocardial ventricle walls. Provided that echographic imaging is good, strain can be computed in athletes by both Doppler-derived and tracking methods. It is technically feasible to use both -interchangeably, at least in basal segments.