The Mei-Yu front is a significantly important summer precipitation system in eastern Asia. In recent years, anthropogenic air pollution over the Yangtze-Huaihe region of China has been aggravating continuously. A cloud-resolving model coupled with an idealized frontal model is used to investigate the response of aerosols on the Mei-Yu frontal precipitation. The results indicate that increasing droplet concentrations lead to significant precipitation enhancement with the current pollution levels in Mei-Yu frontal system. Under the polluted conditions, the enhanced cold-cloud process is of great importance. Moreover, with the “towing” of active cold-cloud process, cold-cloud and warm-cloud processes developed mutually. These account for the complicated and special microphysical mechanism for aerosol impacts on Mei-Yu frontal system. Furthermore, two types of “microphysical-dynamic positive feedback loop” caused by the interactions of various physical processes and effects (direct dynamic effect, frontogenesis effect, and vapor pump effect) can be found in the Mei-Yu precipitation, which in turn reinforce the microphysical processes. The combined effect is to increase Mei-Yu front precipitation. The interaction of microphysical processes and dynamic processes, and the positive feedback loops they create are the main physical mechanisms behind the significant impacts of aerosol on Mei-Yu frontal precipitation. This may also be an important feature of climate change in eastern Asia.